about Lansoprazole class, uses, side effects contraindications
Lansoprazole
Short Description
Lansoprazole is a drug in the group of proton pump inhibitors in the stomach, which blocks the increase in acid in the stomach.
The drug is given in cases of increased stomach acid, such as: esophageal reflux disease, Zollinger-Ellison syndrome, and stomach ulcers, and as part of the treatment of stomach germs (?H. pylori?).
Category
Chemical class: Substituted benzimidazole
Therapeutic class: Antisecretory, antiulcer
Pregnancy category: B
Indications
To treat duodenal ulcers and maintain healed duodenal ulcers DELAYED-RELEASE , DELAYED-RELEASE SUSPENSION, DELAYED-RELEASE ORALLY
Adults.15 to 30 mg daily before morning meal for 4 wk. Maximum: 30 mg daily. To treat gastric ulcers DELAYED-RELEASE , DELAYED-RELEASE SUSPENSION, DELAYED-RELEASE ORALLY
Adults.15 to 30 mg daily before morning meal for up to 8 wk. To treat gastroesophageal reflux disease DELAYED-RELEASE , DELAYED-RELEASE SUSPENSION, DELAYED-RELEASE ORALLY
Adults.15 mg daily before morning meal for up to 8 wk. To treat non-erosive gastroesophageal reflux disease (DEXLANSOPRAZOLE)
Adults. 30 mg once daily for 4 wk. To heal all grades of erosive esophagitis (DEXLANSOPRAZOLE)
Adults.60 mg once daily for up to 8 wk. To maintain healed erosive esophagitis (DEXLANSOPRAZOLE)
Adults. 30 mg once daily. To treat erosive esophagitis DELAYED-RELEASE , DELAYED-RELEASE SUSPENSION, DELAYED-RELEASE ORALLY
Adults.Initial: 30 mg daily before morning meal for up to 8 wk. Continued another 8 wk if indicated. Maintenance: 15 mg daily. To treat erosive esophagitis short-term (up to 7 days) in patients unable to take oral medication
IV:
Adults.30 mg daily infused over 30 min for up to 7 days. To treat pathological hypersecretory conditions, such as Zollinger-Ellison syndrome DELAYED-RELEASE , DELAYED-RELEASE SUSPENSION, DELAYED-RELEASE ORALLY
Adults. Initial: 60 mg daily before morning meal, increased as needed according to patient’s condition. Doses exceeding 120 mg/day administered in divided doses. Maximum: 180 mg daily. To eradicate Helicobacter pylori and reduce risk of duodenal ulcer recurrence DELAYED-RELEASE , DELAYED-RELEASE SUSPENSION, DELAYED-RELEASE ORALLY
Adults.30 mg plus 1 g amoxicillin and 500 mg clarithromycin every 12 hr before meals for 10 to 14 days. Or, 30 mg plus 1 g amoxicillin t.i.d. before meals for 14 days. To treat symptomatic pediatric gastroesophageal reflux disease DELAYED-RELEASE , DELAYED-RELEASE SUSPENSION, DELAYED-RELEASE ORALLY
Children ages 12 to 17. 15 mg daily for up to 8 wk. Children ages 1 to 11 weighing 30 kg (66 lb) or less. 15 mg daily for up to 12 wk. Children ages 1 to 11 weighing more than 30 kg.30 mg daily for up to 12 wk. To treat symptomatic pediatric erosive esophagitis DELAYED-RELEASE , DELAYED-RELEASE SUSPENSION, DELAYED-RELEASE ORALLY
Children ages 12 to 17. 30 mg daily for up to 8 wk. Children ages 1 to 11 weighing 30 kg (66 lb) or less. 15 mg daily for up to 12 wk. Children ages 1 to 11 weighing more than 30 kg. 30 mg daily for up to 12 wk. To treat frequent heartburn (PREVACID24-HR)
Adults. 1 capsule daily for 14 days. May repeat course every 4 months. Route Onset Peak Duration P.O. 1–3 hr Unknown Over 24 hr
Mechanism of Action
Binds to and inactivates the hydrogenpotassium adenosine triphosphate enzyme system (also called the proton pump) in gastric parietal cells. This action blocks the final step of gastric acid production.
Incompatibilities
Don’t give any other with parenteral lansoprazole, and dilute only with solutions recommended by manufacturer (sterile water for initial reconstitution and normal saline solution, lactated Ringer’s solution, or D5W for further dilution).
Contraindications
Hypersensitivity to lansoprazole or its components
Interactions
ampicillin, digoxin, iron salts, ketoconazole, other that depend on low gastric pH for bioavailability: Inhibited absorption of these atazanavir: Decreased blood level and possibly reduced effectiveness of atazanavir sucralfate: Delayed lansoprazole absorption
theophylline: Slightly decreased blood theophylline level
warfarin: Increased INR and PT with possibly increased risk of serious bleeding
Side Efect
CNS: Dizziness, headache
GI: Abdominal pain, anorexia, diarrhea, elevated liver enzymes, hepatotoxicity, increased appetite, nausea, pancreatitis, pseudomembranous colitis, vomiting
GU: Interstitial nephritis, urine retention
HEME: Agranulocytosis, aplastic anemia, decreased hemoglobin, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura
MS: Arthralgia, myositis
RESP: Upper respiratory tract infection
SKIN: Erythema multiforme, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis
Other: Anaphylaxis, hyperkalemia, injection site reaction
Cautions
Give lansoprazole before meals. Antacids may be given as well, if needed. If patient is prescribed capsules and has trouble swallowing them, open and sprinkle granules on applesauce, Ensure, pudlansoprazole 570 ding, cottage cheese, yogurt, or strained pears. Don’t crush granules. Have patient swallow mixture immediately. Or, empty granules into 2 ounces apple, orange, or tomato juice; mix quickly, and have patient swallow immediately. Then add 2 or more ounces of juice to glass and have patient drink immediately to ensure full dose. For delayed-release orally disintegrating tablets, place tablet on patient’s tongue and let it dissolve, with or without water, until patient can swallow particles. For patient with nasogastric tube, don’t use oral suspension. Instead use capsules or orally
. For capsule form, open capsule, mix granules in 40 ml apple juice only, and inject through tube. Then flush tube with apple juice only. For
, place tablet in syringe and draw up 4 ml (for 15-mg tablet) or 8 ml (for 30-mg tablet) of water. Shake gently, and inject through tube within 15 minutes. Then refill syringe with 5 ml of water, shake gently, and inject through tube. For delayed-release oral suspension, empty packet contents into a container with 2 tablespoons water (no other liquids or ), stir well, and have patient drink immediately. If any particles remain in container, add more water, stir, and have patient drink again immediately. Reconstitute parenteral form by injecting 5 ml sterile water into 30-mg drug vial. Mix gently until powder dissolves. Use within 1 hour. After reconstitution, dilute with 50 ml normal saline solution, lactated Ringer’s solution, or D5W. Give within 12 hours if mixed with D5W or 24 hours if mixed with normal saline solution or lactated Ringer’s solution. Give parenteral drug with a filter following manufacturer’s guidelines. Change filter every 24 hours. Give as I.V. infusion over 30 minutes. Flush line with normal saline solution, lactated Ringer’s solution, or D5W before and after giving lansoprazole. Expect to give lansoprazole with antibiotics because decreased gastric acid secretion helps antibiotics eradicate H. pylori. If lansoprazole is given with antibiotics, watch for diarrhea from possible pseudomembranous colitis caused by Clostridium difficile. If diarrhea occurs, notify prescriber and expect to withhold drug and treat with fluids, electrolytes, protein, and an antibiotic effective against C. difficile. PATIENT SAFTY
Urge patient to take drug exactly as prescribed, usually before a meal (preferably breakfast) to decrease gastric acid output. If patient has trouble swallowing dexlansoprazole capsules, tell her to open them and sprinkle granules on 1 tablespoon of applesauce and swallow immediately. If patient has trouble swallowing lansoprazole capsules, tell her to open them and sprinkle granules on applesauce, Ensure, pudding, cottage cheese, yogurt, or strained pears and to swallow immediately without chewing. Or, she may empty granules into 2 ounces of apple, orange, or tomato juice, mix quickly, and swallow immediately. Tell her to refill glass with 2 or more ounces of juice and drink immediately to ensure a full dose. If patient was prescribed delayed-release orally
, tell her to place tablet on tongue, let it dissolve, and then swallow particles with or without water. If patient was prescribed delayed-release oral suspension, tell her to empty contents of packet into a container with 2 tablespoons of water (no other liquids or ), stir well, and drink immediately. If particles remain in container, she should add water, stir, and drink immediately. Inform patient that she may take antacids with lansoprazole. Advise patient to report severe headache, or worsening of symptoms immediately to prescriber. Urge patient to tell prescriber about diarrhea that’s severe or lasts longer than 3 days. Remind patient that watery or bloody stools can occur 2 or more months after antibiotic therapy and can be serious, requiring prompt treatment.
trad drugs based on Lansoprazole
| Gen name | Trade name | Catagory name |
| amoxicillin / clarithromycin / lansoprazole | Prevpac | H2 antagonists |
| dexlansoprazole | Dexilant | Proton pump inhibitors |
| dexlansoprazole | Dexilant SoluTab | Proton pump inhibitors |
| dexlansoprazole | Kapidex | Proton pump inhibitors |
| lansoprazole | Prevacid | Proton pump inhibitors |
| lansoprazole | Prevacid OTC | Proton pump inhibitors |
| lansoprazole | Prevacid SoluTab | Proton pump inhibitors |
| lansoprazole/naproxen | Prevacid NapraPAC | Nonsteroidal anti-inflammatory drugs |
| Lansoprazole | LANFAST 30MG CAPSULE | |
| Lansoprazole | LONZET 15MG CAPSULES | |
| Lansoprazole | LONZET 30MG CAPSULES | |
| Lansoprazole | PEPTAZOLE 15MG CAPSULE | |
| Lansoprazole | PEPTAZOLE 30MG CAPSULE | |
| Lansoprazole | ULTRAZOLE | |
other drugs from same cataogory