The following drugs will decrease ivacaftor effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	3A457	carbamazepine
3	3A457	clobazam
4	3A457	dabrafenib
5	3A457	efavirenz
6	3A457	elagolix
7	3A457	enzalutamide
8	3A457	eslicarbazepine
9	3A457	glucocorticoids
10	3A457	letermovir
11	3A457	lorlatinib
12	3A457	modafinil
13	3A457	nevirapine
14	3A457	oxcarbazepine
15	3A457	perampanel
16	3A457	phenobarbital
17	3A457	phenytoin
18	3A457	pioglitazone
19	3A457	rifabutin
20	3A457	rifampin
21	3A457	St. John's Wort
22	3A457	telotristat
23	3A457	troglitazone
24	3A457	vemurafenib

the follwing drugs will Increase ivacaftor effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	3A457	atomoxetine
3	3A457	boceprevir	under review
4	3A457	ceritinib	Strong inhibitor
5	3A457	chloramphenicol	In-Vitro Only
6	3A457	cimetidine
7	3A457	ciprofloxacin	under review
8	3A457	clarithromycin	Strong inhibitor
9	3A457	crizotinib	Moderate inhibitor
10	3A457	delaviridine	under review
11	3A457	diethyl-dithiocarbamate
12	3A457	diltiazem	Moderate inhibitor
13	3A457	entrectinib
14	3A457	erythromycin	Moderate inhibitor
15	3A457	esomeprazole
16	3A457	fluconazole	Moderate inhibitor
17	3A457	fluvoxamine	under review
18	3A457	gestodene	under review
19	3A457	grapefruit juice	Moderate inhibitor
20	3A457	idelalisib	Strong inhibitor
21	3A457	imatinib	under review
22	3A457	indinavir	Strong inhibitor
23	3A457	itraconazole	Strong inhibitor
24	3A457	ivacaftor
25	3A457	ketoconazole	Strong inhibitor
26	3A457	lesinurad
27	3A457	letermovir
28	3A457	mibefradil	Strong inhibitor
29	3A457	mifepristone	under review
30	3A457	nefazodone	Strong inhibitor
31	3A457	nelfinavir	Strong inhibitor
32	3A457	netupitant/palonosetron	Moderate inhibitor
33	3A457	norfloxacin	under review
34	3A457	norfluoxetine	under review
35	3A457	omeprazole	Weak inhibitor
36	3A457	pantoprazole
37	3A457	perampanel
38	3A457	quercetin
39	3A457	regorafenib	under review
40	3A457	ribociclib	Strong inhibitor
41	3A457	ritonavir	Strong inhibitor
42	3A457	rucaparib
43	3A457	saquinavir	Strong inhibitor
44	3A457	simeprevir
45	3A457	starfruit	under review
46	3A457	telaprevir	under review
47	3A457	telithromycin	Strong inhibitor
48	3A457	ticagrelor
49	3A457	tucatinib	Strong inhibitor
50	3A457	verapamil	Moderate inhibitor
51	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by ivacaftor effect

#	enzyme	drug	level
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	3A457	alectinib
5	3A457	alfentanil
6	3A457	alprazolam
7	3A457	amitriptyline
8	3A457	amlodipine
9	3A457	apixaban
10	3A457	aprepitant
11	3A457	aripiprazole
12	3A457	astemizole
13	3A457	atorvastatin
14	3A457	avanafil
15	3A457	axitinib
16	3A457	boceprevir
17	3A457	bosutinib
18	3A457	brexpiprazole
19	3A457	brigatinib
20	3A457	buspirone
21	3A457	cafergot
22	3A457	caffeine
23	3A457	carbamazepine
24	3A457	cariprazine
25	3A457	ceritinib
26	3A457	cerivastatin
27	3A457	chlorpheniramine
28	3A457	cilostazol
29	3A457	cisapride
30	3A457	citalopram
31	3A457	clarithromycin
32	3A457	clobazam
33	3A457	clopidogrel
34	3A457	cobimetinib
35	3A457	cocaine
36	3A457	codeine
37	3A457	colchicine
38	3A457	copanlisib
39	3A457	crizotinib
40	3A457	cyclosporine
41	3A457	dabrafenib
42	3A457	daclatasvir
43	3A457	dapsone
44	3A457	deflazacort
45	3A457	dexamethasone
46	3A457	dextromethorphan
47	3A457	diazepam
48	3A457	diltiazem
49	3A457	docetaxel
50	3A457	dolutegravir
51	3A457	domperidone
52	3A457	doxepin
53	3A457	elagolix
54	3A457	elbasvir/grazoprevir
55	3A457	eliglustat
56	3A457	enzalutamide
57	3A457	eplerenone
58	3A457	erythromycin2
59	3A457	escitalopram
60	3A457	esomeprazole
61	3A457	estradiol
62	3A457	felodipine
63	3A457	fentanyl
64	3A457	finasteride
65	3A457	flibanserin
66	3A457	gleevec
67	3A457	haloperidol
68	3A457	hydrocortisone
69	3A457	ibrutinib
70	3A457	idelalisib
71	3A457	indacaterol
72	3A457	indinavir
73	3A457	irinotecan
74	3A457	isavuconazonium
75	3A457	ivabradine
76	3A457	ivacaftor
77	3A457	LAAM
78	3A457	lansoprazole
79	3A457	lenvatinib
80	3A457	lercanidipine
81	3A457	lidocaine
82	3A457	linagliptin
83	3A457	lovastatin
84	3A457	macitentan
85	3A457	mavacamten
86	3A457	methadone
87	3A457	midazolam
88	3A457	naldemedine
89	3A457	naloxegol
90	3A457	nateglinide
91	3A457	nelfinavir
92	3A457	neratinib
93	3A457	netupitant/palonosetron
94	3A457	nevirapine
95	3A457	nifedipine
96	3A457	nirmatrelvir
97	3A457	nisoldipine
98	3A457	nitrendipine
99	3A457	olaparib
100	3A457	omeprazole
101	3A457	ondansetron
102	3A457	osimertinib
103	3A457	ospemifene
104	3A457	palbociclib
105	3A457	panobinostat
106	3A457	pantoprazole
107	3A457	perampanel
108	3A457	pimavanserin
109	3A457	pimozide
110	3A457	pomalidomide
111	3A457	ponatinib
112	3A457	progesterone
113	3A457	propranolol
114	3A457	quetiapine
115	3A457	quinidine
116	3A457	quinine
117	3A457	regorafenib
118	3A457	ribociclib
119	3A457	rilpivirine
120	3A457	risperidone
121	3A457	ritonavir
122	3A457	rivaroxaban
123	3A457	roflumilast
124	3A457	rolapitant
125	3A457	romidepsin
126	3A457	rucaparib
127	3A457	ruxolitinib
128	3A457	salmeterol
129	3A457	saquinavir
130	3A457	selexipag
131	3A457	sildenafil
132	3A457	simeprevir
133	3A457	simvastatin
134	3A457	sirolimus
135	3A457	sonidegib
136	3A457	sorafenib
137	3A457	sunitinib
138	3A457	suvorexant
139	3A457	tacrolimus(fk506)
140	3A457	tamoxifen
141	3A457	tasimelteon
142	3A457	taxol
143	3A457	telaprevir
144	3A457	telithromycin
145	3A457	terfenadine
146	3A457	testosterone
147	3A457	ticagrelor
148	3A457	tofacitinib
149	3A457	tolvaptan
150	3A457	torisel
151	3A457	tramadol
152	3A457	trazodone
153	3A457	valbenazine
154	3A457	vandetanib
155	3A457	velpatasvir
156	3A457	vemurafenib
157	3A457	venetoclax
158	3A457	venlafaxine
159	3A457	verapamil
160	3A457	vilazodone
161	3A457	vincristine
162	3A457	vorapaxar
163	3A457	voriconazole
164	3A457	zaleplon
165	3A457	ziprasidone
166	3A457	zolpidem

will decrease ivacaftor effect

#

enzyme

inducers

ivacaftor will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.