check Drug that induced Hemolysis in G6PD Deficiency
Glucose-6-phosphate dehydrogenase deficiency is a genetic disorder that affects red blood cells, which carry oxygen from the lungs to tissues throughout the body.
In affected individuals, a defect in an enzyme called glucose-6-phosphate dehydrogenase causes red blood cells to break down prematurely.
These patients can suffer from hemolytic crises in cases as sever infections, with certain foods, most notably broad beans, certain chemicals and many drugs with variation in response to these substances makes individual predictions difficult.
Antimalarial drugs that can cause acute hemolysis in people with G6PD deficiency include primaquine, pamaquine, chloroquine, and hydroxychloroquine.
There is evidence that other antimalarials may also exacerbate G6PD deficiency, but only at higher doses.
Sulfonamides (such as sulfanilamide, sulfamethoxazole, and mafenide), thiazolesulfone, methylene blue, and naphthalene should also be avoided by people with G6PD deficiency as they antagonize folate synthesis, as should certain analgesics (such as phenazopyridine and acetanilide) and a few non-sulfa antibiotics (nalidixic acid, nitrofurantoin, isoniazid, dapsone, and furazolidone).Henna has been known to cause hemolytic crisis in G6PD-deficient infants.