The following drugs will decrease perampanel effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	3A457	carbamazepine
3	3A457	clobazam
4	3A457	dabrafenib
5	3A457	efavirenz
6	3A457	elagolix
7	3A457	enzalutamide
8	3A457	eslicarbazepine
9	3A457	glucocorticoids
10	3A457	letermovir
11	3A457	lorlatinib
12	3A457	modafinil
13	3A457	nevirapine
14	3A457	oxcarbazepine
15	3A457	perampanel
16	3A457	phenobarbital
17	3A457	phenytoin
18	3A457	pioglitazone
19	3A457	rifabutin
20	3A457	rifampin
21	3A457	St. John's Wort
22	3A457	telotristat
23	3A457	troglitazone
24	3A457	vemurafenib

the follwing drugs will Increase perampanel effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	3A457	atomoxetine
3	3A457	boceprevir	under review
4	3A457	ceritinib	Strong inhibitor
5	3A457	chloramphenicol	In-Vitro Only
6	3A457	cimetidine
7	3A457	ciprofloxacin	under review
8	3A457	clarithromycin	Strong inhibitor
9	3A457	crizotinib	Moderate inhibitor
10	3A457	delaviridine	under review
11	3A457	diethyl-dithiocarbamate
12	3A457	diltiazem	Moderate inhibitor
13	3A457	entrectinib
14	3A457	erythromycin	Moderate inhibitor
15	3A457	esomeprazole
16	3A457	fluconazole	Moderate inhibitor
17	3A457	fluvoxamine	under review
18	3A457	gestodene	under review
19	3A457	grapefruit juice	Moderate inhibitor
20	3A457	idelalisib	Strong inhibitor
21	3A457	imatinib	under review
22	3A457	indinavir	Strong inhibitor
23	3A457	itraconazole	Strong inhibitor
24	3A457	ivacaftor
25	3A457	ketoconazole	Strong inhibitor
26	3A457	lesinurad
27	3A457	letermovir
28	3A457	mibefradil	Strong inhibitor
29	3A457	mifepristone	under review
30	3A457	nefazodone	Strong inhibitor
31	3A457	nelfinavir	Strong inhibitor
32	3A457	netupitant/palonosetron	Moderate inhibitor
33	3A457	norfloxacin	under review
34	3A457	norfluoxetine	under review
35	3A457	omeprazole	Weak inhibitor
36	3A457	pantoprazole
37	3A457	perampanel
38	3A457	quercetin
39	3A457	regorafenib	under review
40	3A457	ribociclib	Strong inhibitor
41	3A457	ritonavir	Strong inhibitor
42	3A457	rucaparib
43	3A457	saquinavir	Strong inhibitor
44	3A457	simeprevir
45	3A457	starfruit	under review
46	3A457	telaprevir	under review
47	3A457	telithromycin	Strong inhibitor
48	3A457	ticagrelor
49	3A457	tucatinib	Strong inhibitor
50	3A457	verapamil	Moderate inhibitor
51	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by perampanel effect

#	enzyme	drug	level
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	3A457	alectinib
5	3A457	alfentanil
6	3A457	alprazolam
7	3A457	amitriptyline
8	3A457	amlodipine
9	2C8	amodiaquine	In-Vitro Only
10	3A457	apixaban
11	3A457	aprepitant
12	3A457	aripiprazole
13	3A457	astemizole
14	3A457	atorvastatin
15	3A457	avanafil
16	3A457	axitinib
17	3A457	boceprevir
18	3A457	bosutinib
19	3A457	brexpiprazole
20	3A457	brigatinib
21	3A457	buspirone
22	3A457	cafergot
23	3A457	caffeine
24	3A457	carbamazepine
25	3A457	cariprazine
26	3A457	ceritinib
27	2C8	cerivastatin	In-Vitro Only
28	3A457	cerivastatin
29	3A457	chlorpheniramine
30	3A457	cilostazol
31	3A457	cisapride
32	3A457	citalopram
33	3A457	clarithromycin
34	3A457	clobazam
35	3A457	clopidogrel
36	3A457	cobimetinib
37	3A457	cocaine
38	3A457	codeine
39	3A457	colchicine
40	3A457	copanlisib
41	3A457	crizotinib
42	3A457	cyclosporine
43	2C8	dabrafenib	In-Vitro Only
44	3A457	dabrafenib
45	3A457	daclatasvir
46	3A457	dapsone
47	3A457	deflazacort
48	3A457	dexamethasone
49	3A457	dextromethorphan
50	3A457	diazepam
51	3A457	diltiazem
52	3A457	docetaxel
53	3A457	dolutegravir
54	3A457	domperidone
55	3A457	doxepin
56	3A457	elagolix
57	3A457	elbasvir/grazoprevir
58	3A457	eliglustat
59	2C8	enzalutamide	In-Vitro Only
60	3A457	enzalutamide
61	3A457	eplerenone
62	3A457	erythromycin2
63	3A457	escitalopram
64	3A457	esomeprazole
65	3A457	estradiol
66	3A457	felodipine
67	3A457	fentanyl
68	3A457	finasteride
69	3A457	flibanserin
70	3A457	gleevec
71	3A457	haloperidol
72	3A457	hydrocortisone
73	3A457	ibrutinib
74	3A457	idelalisib
75	3A457	indacaterol
76	3A457	indinavir
77	3A457	irinotecan
78	3A457	isavuconazonium
79	3A457	ivabradine
80	3A457	ivacaftor
81	3A457	LAAM
82	3A457	lansoprazole
83	3A457	lenvatinib
84	3A457	lercanidipine
85	3A457	lidocaine
86	3A457	linagliptin
87	3A457	lovastatin
88	3A457	macitentan
89	3A457	mavacamten
90	3A457	methadone
91	3A457	midazolam
92	3A457	naldemedine
93	3A457	naloxegol
94	3A457	nateglinide
95	3A457	nelfinavir
96	3A457	neratinib
97	3A457	netupitant/palonosetron
98	3A457	nevirapine
99	3A457	nifedipine
100	3A457	nirmatrelvir
101	3A457	nisoldipine
102	3A457	nitrendipine
103	3A457	olaparib
104	2C8	olodaterol	In-Vitro Only
105	3A457	omeprazole
106	3A457	ondansetron
107	3A457	osimertinib
108	3A457	ospemifene
109	2C8	paclitaxel	In-Vitro Only
110	3A457	palbociclib
111	3A457	panobinostat
112	3A457	pantoprazole
113	3A457	perampanel
114	3A457	pimavanserin
115	3A457	pimozide
116	3A457	pomalidomide
117	2C8	ponatinib	In-Vitro Only
118	3A457	ponatinib
119	3A457	progesterone
120	3A457	propranolol
121	3A457	quetiapine
122	3A457	quinidine
123	3A457	quinine
124	3A457	regorafenib
125	2C8	repaglinide	In-Vitro Only
126	3A457	ribociclib
127	3A457	rilpivirine
128	3A457	risperidone
129	3A457	ritonavir
130	3A457	rivaroxaban
131	3A457	roflumilast
132	3A457	rolapitant
133	3A457	romidepsin
134	3A457	rucaparib
135	3A457	ruxolitinib
136	3A457	salmeterol
137	3A457	saquinavir
138	2C8	selexipag	In-Vitro Only
139	3A457	selexipag
140	3A457	sildenafil
141	3A457	simeprevir
142	3A457	simvastatin
143	3A457	sirolimus
144	3A457	sonidegib
145	2C8	sorafenib	In-Vitro Only
146	3A457	sorafenib
147	3A457	sunitinib
148	3A457	suvorexant
149	3A457	tacrolimus(fk506)
150	3A457	tamoxifen
151	3A457	tasimelteon
152	3A457	taxol
153	3A457	telaprevir
154	3A457	telithromycin
155	3A457	terfenadine
156	3A457	testosterone
157	3A457	ticagrelor
158	3A457	tofacitinib
159	3A457	tolvaptan
160	3A457	torisel
161	2C8	torsemide	In-Vitro Only
162	3A457	tramadol
163	3A457	trazodone
164	2C8	tucatinib	In-Vitro Only
165	3A457	valbenazine
166	3A457	vandetanib
167	3A457	velpatasvir
168	3A457	vemurafenib
169	3A457	venetoclax
170	3A457	venlafaxine
171	3A457	verapamil
172	3A457	vilazodone
173	3A457	vincristine
174	3A457	vorapaxar
175	3A457	voriconazole
176	3A457	zaleplon
177	3A457	ziprasidone
178	3A457	zolpidem

The following drugs will decreased effect by perampanel effect

#	enzyme	drug
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	3A457	alectinib
5	3A457	alfentanil
6	3A457	alprazolam
7	3A457	amitriptyline
8	3A457	amlodipine
9	3A457	apixaban
10	3A457	aprepitant
11	3A457	aripiprazole
12	2B6	artemisinin
13	3A457	astemizole
14	3A457	atorvastatin
15	3A457	avanafil
16	3A457	axitinib
17	3A457	boceprevir
18	3A457	bosutinib
19	3A457	brexpiprazole
20	3A457	brigatinib
21	2B6	bupropion
22	3A457	buspirone
23	3A457	cafergot
24	3A457	caffeine
25	3A457	carbamazepine
26	3A457	cariprazine
27	3A457	ceritinib
28	3A457	cerivastatin
29	3A457	chlorpheniramine
30	3A457	cilostazol
31	3A457	cisapride
32	3A457	citalopram
33	3A457	clarithromycin
34	2B6	clobazam
35	3A457	clobazam
36	3A457	clopidogrel
37	3A457	cobimetinib
38	3A457	cocaine
39	3A457	codeine
40	3A457	colchicine
41	3A457	copanlisib
42	3A457	crizotinib
43	2B6	cyclophosphamide
44	3A457	cyclosporine
45	3A457	dabrafenib
46	3A457	daclatasvir
47	3A457	dapsone
48	3A457	deflazacort
49	3A457	dexamethasone
50	3A457	dextromethorphan
51	3A457	diazepam
52	3A457	diltiazem
53	3A457	docetaxel
54	3A457	dolutegravir
55	3A457	domperidone
56	3A457	doxepin
57	2B6	efavirenz
58	3A457	elagolix
59	3A457	elbasvir/grazoprevir
60	3A457	eliglustat
61	3A457	enzalutamide
62	3A457	eplerenone
63	3A457	erythromycin2
64	3A457	escitalopram
65	3A457	esomeprazole
66	3A457	estradiol
67	3A457	felodipine
68	3A457	fentanyl
69	3A457	finasteride
70	3A457	flibanserin
71	3A457	gleevec
72	3A457	haloperidol
73	3A457	hydrocortisone
74	3A457	ibrutinib
75	3A457	idelalisib
76	2B6	ifosphamide
77	3A457	indacaterol
78	3A457	indinavir
79	3A457	irinotecan
80	3A457	isavuconazonium
81	3A457	ivabradine
82	3A457	ivacaftor
83	2B6	ketamine
84	3A457	LAAM
85	3A457	lansoprazole
86	3A457	lenvatinib
87	3A457	lercanidipine
88	3A457	lidocaine
89	3A457	linagliptin
90	3A457	lovastatin
91	3A457	macitentan
92	3A457	mavacamten
93	2B6	meperidine
94	2B6	methadone
95	3A457	methadone
96	3A457	midazolam
97	3A457	naldemedine
98	3A457	naloxegol
99	3A457	nateglinide
100	3A457	nelfinavir
101	3A457	neratinib
102	3A457	netupitant/palonosetron
103	2B6	nevirapine
104	3A457	nevirapine
105	3A457	nifedipine
106	3A457	nirmatrelvir
107	3A457	nisoldipine
108	3A457	nitrendipine
109	3A457	olaparib
110	3A457	omeprazole
111	3A457	ondansetron
112	3A457	osimertinib
113	3A457	ospemifene
114	3A457	palbociclib
115	3A457	panobinostat
116	3A457	pantoprazole
117	3A457	perampanel
118	3A457	pimavanserin
119	3A457	pimozide
120	3A457	pomalidomide
121	3A457	ponatinib
122	3A457	progesterone
123	2B6	propafol
124	3A457	propranolol
125	3A457	quetiapine
126	3A457	quinidine
127	3A457	quinine
128	3A457	regorafenib
129	3A457	ribociclib
130	3A457	rilpivirine
131	3A457	risperidone
132	3A457	ritonavir
133	3A457	rivaroxaban
134	3A457	roflumilast
135	3A457	rolapitant
136	3A457	romidepsin
137	3A457	rucaparib
138	3A457	ruxolitinib
139	3A457	salmeterol
140	3A457	saquinavir
141	2B6	selegiline
142	3A457	selexipag
143	3A457	sildenafil
144	3A457	simeprevir
145	3A457	simvastatin
146	3A457	sirolimus
147	3A457	sonidegib
148	2B6	sorafenib
149	3A457	sorafenib
150	3A457	sunitinib
151	3A457	suvorexant
152	3A457	tacrolimus(fk506)
153	3A457	tamoxifen
154	3A457	tasimelteon
155	3A457	taxol
156	3A457	telaprevir
157	3A457	telithromycin
158	3A457	terfenadine
159	3A457	testosterone
160	3A457	ticagrelor
161	3A457	tofacitinib
162	3A457	tolvaptan
163	3A457	torisel
164	2B6	tramadol
165	3A457	tramadol
166	3A457	trazodone
167	3A457	valbenazine
168	3A457	vandetanib
169	2B6	velpatasvir
170	3A457	velpatasvir
171	3A457	vemurafenib
172	3A457	venetoclax
173	3A457	venlafaxine
174	3A457	verapamil
175	3A457	vilazodone
176	3A457	vincristine
177	3A457	vorapaxar
178	3A457	voriconazole
179	3A457	zaleplon
180	3A457	ziprasidone
181	3A457	zolpidem

will decrease perampanel effect

#

enzyme

inducers

perampanel will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.