regorafenib
The following drugs will decrease regorafenib effect
# | enzyme | inducers |
0 | 3A457 | barbiturates |
1 | 3A457 | brigatinib |
2 | 3A457 | carbamazepine |
3 | 3A457 | clobazam |
4 | 3A457 | dabrafenib |
5 | 3A457 | efavirenz |
6 | 3A457 | elagolix |
7 | 3A457 | enzalutamide |
8 | 3A457 | eslicarbazepine |
9 | 3A457 | glucocorticoids |
10 | 3A457 | letermovir |
11 | 3A457 | lorlatinib |
12 | 3A457 | modafinil |
13 | 3A457 | nevirapine |
14 | 3A457 | oxcarbazepine |
15 | 3A457 | perampanel |
16 | 3A457 | phenobarbital |
17 | 3A457 | phenytoin |
18 | 3A457 | pioglitazone |
19 | 3A457 | rifabutin |
20 | 3A457 | rifampin |
21 | 3A457 | St. John's Wort |
22 | 3A457 | telotristat |
23 | 3A457 | troglitazone |
24 | 3A457 | vemurafenib |
the follwing drugs will
Increase regorafenib effect
# | enzyme | Inhibitors | level |
0 | 3A457 | amiodarone | under review |
1 | 3A457 | aprepitant | Moderate inhibitor |
2 | 3A457 | atomoxetine | |
3 | 3A457 | boceprevir | under review |
4 | 3A457 | ceritinib | Strong inhibitor |
5 | 3A457 | chloramphenicol | In-Vitro Only |
6 | 3A457 | cimetidine | |
7 | 3A457 | ciprofloxacin | under review |
8 | 3A457 | clarithromycin | Strong inhibitor |
9 | 3A457 | crizotinib | Moderate inhibitor |
10 | 3A457 | delaviridine | under review |
11 | 3A457 | diethyl-dithiocarbamate | |
12 | 3A457 | diltiazem | Moderate inhibitor |
13 | 3A457 | entrectinib | |
14 | 3A457 | erythromycin | Moderate inhibitor |
15 | 3A457 | esomeprazole | |
16 | 3A457 | fluconazole | Moderate inhibitor |
17 | 3A457 | fluvoxamine | under review |
18 | 3A457 | gestodene | under review |
19 | 3A457 | grapefruit juice | Moderate inhibitor |
20 | 3A457 | idelalisib | Strong inhibitor |
21 | 3A457 | imatinib | under review |
22 | 3A457 | indinavir | Strong inhibitor |
23 | 3A457 | itraconazole | Strong inhibitor |
24 | 3A457 | ivacaftor | |
25 | 3A457 | ketoconazole | Strong inhibitor |
26 | 3A457 | lesinurad | |
27 | 3A457 | letermovir | |
28 | 3A457 | mibefradil | Strong inhibitor |
29 | 3A457 | mifepristone | under review |
30 | 3A457 | nefazodone | Strong inhibitor |
31 | 3A457 | nelfinavir | Strong inhibitor |
32 | 3A457 | netupitant/palonosetron | Moderate inhibitor |
33 | 3A457 | norfloxacin | under review |
34 | 3A457 | norfluoxetine | under review |
35 | 3A457 | omeprazole | Weak inhibitor |
36 | 3A457 | pantoprazole | |
37 | 3A457 | perampanel | |
38 | 3A457 | quercetin | |
39 | 3A457 | regorafenib | under review |
40 | 3A457 | ribociclib | Strong inhibitor |
41 | 3A457 | ritonavir | Strong inhibitor |
42 | 3A457 | rucaparib | |
43 | 3A457 | saquinavir | Strong inhibitor |
44 | 3A457 | simeprevir | |
45 | 3A457 | starfruit | under review |
46 | 3A457 | telaprevir | under review |
47 | 3A457 | telithromycin | Strong inhibitor |
48 | 3A457 | ticagrelor | |
49 | 3A457 | tucatinib | Strong inhibitor |
50 | 3A457 | verapamil | Moderate inhibitor |
51 | 3A457 | voriconazole | Strong inhibitor |
The follwing drugs will Increase effect by regorafenib effect
# | enzyme | drug | level |
1 | 3A457 | abemaciclib | under review |
2 | 3A457 | abiraterone | under review |
3 | 3A457 | acalabrutinib | under review |
4 | 3A457 | alectinib | under review |
5 | 3A457 | alfentanil | under review |
6 | 3A457 | alprazolam | under review |
7 | 3A457 | amitriptyline | under review |
8 | 3A457 | amlodipine | under review |
9 | 3A457 | apixaban | under review |
10 | 3A457 | aprepitant | under review |
11 | 3A457 | aripiprazole | under review |
12 | 3A457 | astemizole | under review |
13 | 3A457 | atorvastatin | under review |
14 | 3A457 | avanafil | under review |
15 | 3A457 | axitinib | under review |
16 | 3A457 | boceprevir | under review |
17 | 3A457 | bosutinib | under review |
18 | 3A457 | brexpiprazole | under review |
19 | 3A457 | brigatinib | under review |
20 | 3A457 | buspirone | under review |
21 | 3A457 | cafergot | under review |
22 | 3A457 | caffeine | under review |
23 | 3A457 | carbamazepine | under review |
24 | 3A457 | cariprazine | under review |
25 | 3A457 | ceritinib | under review |
26 | 3A457 | cerivastatin | under review |
27 | 3A457 | chlorpheniramine | under review |
28 | 3A457 | cilostazol | under review |
29 | 3A457 | cisapride | under review |
30 | 3A457 | citalopram | under review |
31 | 3A457 | clarithromycin | under review |
32 | 3A457 | clobazam | under review |
33 | 3A457 | clopidogrel | under review |
34 | 3A457 | cobimetinib | under review |
35 | 3A457 | cocaine | under review |
36 | 3A457 | codeine | under review |
37 | 3A457 | colchicine | under review |
38 | 3A457 | copanlisib | under review |
39 | 3A457 | crizotinib | under review |
40 | 3A457 | cyclosporine | under review |
41 | 3A457 | dabrafenib | under review |
42 | 3A457 | daclatasvir | under review |
43 | 3A457 | dapsone | under review |
44 | 3A457 | deflazacort | under review |
45 | 3A457 | dexamethasone | under review |
46 | 3A457 | dextromethorphan | under review |
47 | 3A457 | diazepam | under review |
48 | 3A457 | diltiazem | under review |
49 | 3A457 | docetaxel | under review |
50 | 3A457 | dolutegravir | under review |
51 | 3A457 | domperidone | under review |
52 | 3A457 | doxepin | under review |
53 | 3A457 | elagolix | under review |
54 | 3A457 | elbasvir/grazoprevir | under review |
55 | 3A457 | eliglustat | under review |
56 | 3A457 | enzalutamide | under review |
57 | 3A457 | eplerenone | under review |
58 | 3A457 | erythromycin2 | under review |
59 | 3A457 | escitalopram | under review |
60 | 3A457 | esomeprazole | under review |
61 | 3A457 | estradiol | under review |
62 | 3A457 | felodipine | under review |
63 | 3A457 | fentanyl | under review |
64 | 3A457 | finasteride | under review |
65 | 3A457 | flibanserin | under review |
66 | 3A457 | gleevec | under review |
67 | 3A457 | haloperidol | under review |
68 | 3A457 | hydrocortisone | under review |
69 | 3A457 | ibrutinib | under review |
70 | 3A457 | idelalisib | under review |
71 | 3A457 | indacaterol | under review |
72 | 3A457 | indinavir | under review |
73 | 3A457 | irinotecan | under review |
74 | 3A457 | isavuconazonium | under review |
75 | 3A457 | ivabradine | under review |
76 | 3A457 | ivacaftor | under review |
77 | 3A457 | LAAM | under review |
78 | 3A457 | lansoprazole | under review |
79 | 3A457 | lenvatinib | under review |
80 | 3A457 | lercanidipine | under review |
81 | 3A457 | lidocaine | under review |
82 | 3A457 | linagliptin | under review |
83 | 3A457 | lovastatin | under review |
84 | 3A457 | macitentan | under review |
85 | 3A457 | mavacamten | under review |
86 | 3A457 | methadone | under review |
87 | 3A457 | midazolam | under review |
88 | 3A457 | naldemedine | under review |
89 | 3A457 | naloxegol | under review |
90 | 3A457 | nateglinide | under review |
91 | 3A457 | nelfinavir | under review |
92 | 3A457 | neratinib | under review |
93 | 3A457 | netupitant/palonosetron | under review |
94 | 3A457 | nevirapine | under review |
95 | 3A457 | nifedipine | under review |
96 | 3A457 | nirmatrelvir | under review |
97 | 3A457 | nisoldipine | under review |
98 | 3A457 | nitrendipine | under review |
99 | 3A457 | olaparib | under review |
100 | 3A457 | omeprazole | under review |
101 | 3A457 | ondansetron | under review |
102 | 3A457 | osimertinib | under review |
103 | 3A457 | ospemifene | under review |
104 | 3A457 | palbociclib | under review |
105 | 3A457 | panobinostat | under review |
106 | 3A457 | pantoprazole | under review |
107 | 3A457 | perampanel | under review |
108 | 3A457 | pimavanserin | under review |
109 | 3A457 | pimozide | under review |
110 | 3A457 | pomalidomide | under review |
111 | 3A457 | ponatinib | under review |
112 | 3A457 | progesterone | under review |
113 | 3A457 | propranolol | under review |
114 | 3A457 | quetiapine | under review |
115 | 3A457 | quinidine | under review |
116 | 3A457 | quinine | under review |
117 | 3A457 | regorafenib | under review |
118 | 3A457 | ribociclib | under review |
119 | 3A457 | rilpivirine | under review |
120 | 3A457 | risperidone | under review |
121 | 3A457 | ritonavir | under review |
122 | 3A457 | rivaroxaban | under review |
123 | 3A457 | roflumilast | under review |
124 | 3A457 | rolapitant | under review |
125 | 3A457 | romidepsin | under review |
126 | 3A457 | rucaparib | under review |
127 | 3A457 | ruxolitinib | under review |
128 | 3A457 | salmeterol | under review |
129 | 3A457 | saquinavir | under review |
130 | 3A457 | selexipag | under review |
131 | 3A457 | sildenafil | under review |
132 | 3A457 | simeprevir | under review |
133 | 3A457 | simvastatin | under review |
134 | 3A457 | sirolimus | under review |
135 | 3A457 | sonidegib | under review |
136 | 3A457 | sorafenib | under review |
137 | 3A457 | sunitinib | under review |
138 | 3A457 | suvorexant | under review |
139 | 3A457 | tacrolimus(fk506) | under review |
140 | 3A457 | tamoxifen | under review |
141 | 3A457 | tasimelteon | under review |
142 | 3A457 | taxol | under review |
143 | 3A457 | telaprevir | under review |
144 | 3A457 | telithromycin | under review |
145 | 3A457 | terfenadine | under review |
146 | 3A457 | testosterone | under review |
147 | 3A457 | ticagrelor | under review |
148 | 3A457 | tofacitinib | under review |
149 | 3A457 | tolvaptan | under review |
150 | 3A457 | torisel | under review |
151 | 3A457 | tramadol | under review |
152 | 3A457 | trazodone | under review |
153 | 3A457 | valbenazine | under review |
154 | 3A457 | vandetanib | under review |
155 | 3A457 | velpatasvir | under review |
156 | 3A457 | vemurafenib | under review |
157 | 3A457 | venetoclax | under review |
158 | 3A457 | venlafaxine | under review |
159 | 3A457 | verapamil | under review |
160 | 3A457 | vilazodone | under review |
161 | 3A457 | vincristine | under review |
162 | 3A457 | vorapaxar | under review |
163 | 3A457 | voriconazole | under review |
164 | 3A457 | zaleplon | under review |
165 | 3A457 | ziprasidone | under review |
166 | 3A457 | zolpidem | under review |
will
decrease regorafenib effect
regorafenib will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.