clarithromycin
The following drugs will decrease clarithromycin effect
| # | enzyme | inducers |
| 0 | 3A457 | barbiturates |
| 1 | 3A457 | brigatinib |
| 2 | 3A457 | carbamazepine |
| 3 | 3A457 | clobazam |
| 4 | 3A457 | dabrafenib |
| 5 | 3A457 | efavirenz |
| 6 | 3A457 | elagolix |
| 7 | 3A457 | enzalutamide |
| 8 | 3A457 | eslicarbazepine |
| 9 | 3A457 | glucocorticoids |
| 10 | 3A457 | letermovir |
| 11 | 3A457 | lorlatinib |
| 12 | 3A457 | modafinil |
| 13 | 3A457 | nevirapine |
| 14 | 3A457 | oxcarbazepine |
| 15 | 3A457 | perampanel |
| 16 | 3A457 | phenobarbital |
| 17 | 3A457 | phenytoin |
| 18 | 3A457 | pioglitazone |
| 19 | 3A457 | rifabutin |
| 20 | 3A457 | rifampin |
| 21 | 3A457 | St. John's Wort |
| 22 | 3A457 | telotristat |
| 23 | 3A457 | troglitazone |
| 24 | 3A457 | vemurafenib |
the follwing drugs will
Increase clarithromycin effect
| # | enzyme | Inhibitors | level |
| 0 | 3A457 | amiodarone | under review |
| 1 | 3A457 | aprepitant | Moderate inhibitor |
| 2 | 3A457 | atomoxetine | |
| 3 | 3A457 | boceprevir | under review |
| 4 | 3A457 | ceritinib | Strong inhibitor |
| 5 | 3A457 | chloramphenicol | In-Vitro Only |
| 6 | 3A457 | cimetidine | |
| 7 | 3A457 | ciprofloxacin | under review |
| 8 | 3A457 | clarithromycin | Strong inhibitor |
| 9 | 3A457 | crizotinib | Moderate inhibitor |
| 10 | 3A457 | delaviridine | under review |
| 11 | 3A457 | diethyl-dithiocarbamate | |
| 12 | 3A457 | diltiazem | Moderate inhibitor |
| 13 | 3A457 | entrectinib | |
| 14 | 3A457 | erythromycin | Moderate inhibitor |
| 15 | 3A457 | esomeprazole | |
| 16 | 3A457 | fluconazole | Moderate inhibitor |
| 17 | 3A457 | fluvoxamine | under review |
| 18 | 3A457 | gestodene | under review |
| 19 | 3A457 | grapefruit juice | Moderate inhibitor |
| 20 | 3A457 | idelalisib | Strong inhibitor |
| 21 | 3A457 | imatinib | under review |
| 22 | 3A457 | indinavir | Strong inhibitor |
| 23 | 3A457 | itraconazole | Strong inhibitor |
| 24 | 3A457 | ivacaftor | |
| 25 | 3A457 | ketoconazole | Strong inhibitor |
| 26 | 3A457 | lesinurad | |
| 27 | 3A457 | letermovir | |
| 28 | 3A457 | mibefradil | Strong inhibitor |
| 29 | 3A457 | mifepristone | under review |
| 30 | 3A457 | nefazodone | Strong inhibitor |
| 31 | 3A457 | nelfinavir | Strong inhibitor |
| 32 | 3A457 | netupitant/palonosetron | Moderate inhibitor |
| 33 | 3A457 | norfloxacin | under review |
| 34 | 3A457 | norfluoxetine | under review |
| 35 | 3A457 | omeprazole | Weak inhibitor |
| 36 | 3A457 | pantoprazole | |
| 37 | 3A457 | perampanel | |
| 38 | 3A457 | quercetin | |
| 39 | 3A457 | regorafenib | under review |
| 40 | 3A457 | ribociclib | Strong inhibitor |
| 41 | 3A457 | ritonavir | Strong inhibitor |
| 42 | 3A457 | rucaparib | |
| 43 | 3A457 | saquinavir | Strong inhibitor |
| 44 | 3A457 | simeprevir | |
| 45 | 3A457 | starfruit | under review |
| 46 | 3A457 | telaprevir | under review |
| 47 | 3A457 | telithromycin | Strong inhibitor |
| 48 | 3A457 | ticagrelor | |
| 49 | 3A457 | tucatinib | Strong inhibitor |
| 50 | 3A457 | verapamil | Moderate inhibitor |
| 51 | 3A457 | voriconazole | Strong inhibitor |
The follwing drugs will Increase effect by clarithromycin effect
| # | enzyme | drug | level |
| 1 | 3A457 | abemaciclib | Strong inhibitor |
| 2 | 3A457 | abiraterone | Strong inhibitor |
| 3 | 3A457 | acalabrutinib | Strong inhibitor |
| 4 | 3A457 | alectinib | Strong inhibitor |
| 5 | 3A457 | alfentanil | Strong inhibitor |
| 6 | 3A457 | alprazolam | Strong inhibitor |
| 7 | 3A457 | amitriptyline | Strong inhibitor |
| 8 | 3A457 | amlodipine | Strong inhibitor |
| 9 | 3A457 | apixaban | Strong inhibitor |
| 10 | 3A457 | aprepitant | Strong inhibitor |
| 11 | 3A457 | aripiprazole | Strong inhibitor |
| 12 | 3A457 | astemizole | Strong inhibitor |
| 13 | 3A457 | atorvastatin | Strong inhibitor |
| 14 | 3A457 | avanafil | Strong inhibitor |
| 15 | 3A457 | axitinib | Strong inhibitor |
| 16 | 3A457 | boceprevir | Strong inhibitor |
| 17 | 3A457 | bosutinib | Strong inhibitor |
| 18 | 3A457 | brexpiprazole | Strong inhibitor |
| 19 | 3A457 | brigatinib | Strong inhibitor |
| 20 | 3A457 | buspirone | Strong inhibitor |
| 21 | 3A457 | cafergot | Strong inhibitor |
| 22 | 3A457 | caffeine | Strong inhibitor |
| 23 | 3A457 | carbamazepine | Strong inhibitor |
| 24 | 3A457 | cariprazine | Strong inhibitor |
| 25 | 3A457 | ceritinib | Strong inhibitor |
| 26 | 3A457 | cerivastatin | Strong inhibitor |
| 27 | 3A457 | chlorpheniramine | Strong inhibitor |
| 28 | 3A457 | cilostazol | Strong inhibitor |
| 29 | 3A457 | cisapride | Strong inhibitor |
| 30 | 3A457 | citalopram | Strong inhibitor |
| 31 | 3A457 | clarithromycin | Strong inhibitor |
| 32 | 3A457 | clobazam | Strong inhibitor |
| 33 | 3A457 | clopidogrel | Strong inhibitor |
| 34 | 3A457 | cobimetinib | Strong inhibitor |
| 35 | 3A457 | cocaine | Strong inhibitor |
| 36 | 3A457 | codeine | Strong inhibitor |
| 37 | 3A457 | colchicine | Strong inhibitor |
| 38 | 3A457 | copanlisib | Strong inhibitor |
| 39 | 3A457 | crizotinib | Strong inhibitor |
| 40 | 3A457 | cyclosporine | Strong inhibitor |
| 41 | 3A457 | dabrafenib | Strong inhibitor |
| 42 | 3A457 | daclatasvir | Strong inhibitor |
| 43 | 3A457 | dapsone | Strong inhibitor |
| 44 | 3A457 | deflazacort | Strong inhibitor |
| 45 | 3A457 | dexamethasone | Strong inhibitor |
| 46 | 3A457 | dextromethorphan | Strong inhibitor |
| 47 | 3A457 | diazepam | Strong inhibitor |
| 48 | 3A457 | diltiazem | Strong inhibitor |
| 49 | 3A457 | docetaxel | Strong inhibitor |
| 50 | 3A457 | dolutegravir | Strong inhibitor |
| 51 | 3A457 | domperidone | Strong inhibitor |
| 52 | 3A457 | doxepin | Strong inhibitor |
| 53 | 3A457 | elagolix | Strong inhibitor |
| 54 | 3A457 | elbasvir/grazoprevir | Strong inhibitor |
| 55 | 3A457 | eliglustat | Strong inhibitor |
| 56 | 3A457 | enzalutamide | Strong inhibitor |
| 57 | 3A457 | eplerenone | Strong inhibitor |
| 58 | 3A457 | erythromycin2 | Strong inhibitor |
| 59 | 3A457 | escitalopram | Strong inhibitor |
| 60 | 3A457 | esomeprazole | Strong inhibitor |
| 61 | 3A457 | estradiol | Strong inhibitor |
| 62 | 3A457 | felodipine | Strong inhibitor |
| 63 | 3A457 | fentanyl | Strong inhibitor |
| 64 | 3A457 | finasteride | Strong inhibitor |
| 65 | 3A457 | flibanserin | Strong inhibitor |
| 66 | 3A457 | gleevec | Strong inhibitor |
| 67 | 3A457 | haloperidol | Strong inhibitor |
| 68 | 3A457 | hydrocortisone | Strong inhibitor |
| 69 | 3A457 | ibrutinib | Strong inhibitor |
| 70 | 3A457 | idelalisib | Strong inhibitor |
| 71 | 3A457 | indacaterol | Strong inhibitor |
| 72 | 3A457 | indinavir | Strong inhibitor |
| 73 | 3A457 | irinotecan | Strong inhibitor |
| 74 | 3A457 | isavuconazonium | Strong inhibitor |
| 75 | 3A457 | ivabradine | Strong inhibitor |
| 76 | 3A457 | ivacaftor | Strong inhibitor |
| 77 | 3A457 | LAAM | Strong inhibitor |
| 78 | 3A457 | lansoprazole | Strong inhibitor |
| 79 | 3A457 | lenvatinib | Strong inhibitor |
| 80 | 3A457 | lercanidipine | Strong inhibitor |
| 81 | 3A457 | lidocaine | Strong inhibitor |
| 82 | 3A457 | linagliptin | Strong inhibitor |
| 83 | 3A457 | lovastatin | Strong inhibitor |
| 84 | 3A457 | macitentan | Strong inhibitor |
| 85 | 3A457 | mavacamten | Strong inhibitor |
| 86 | 3A457 | methadone | Strong inhibitor |
| 87 | 3A457 | midazolam | Strong inhibitor |
| 88 | 3A457 | naldemedine | Strong inhibitor |
| 89 | 3A457 | naloxegol | Strong inhibitor |
| 90 | 3A457 | nateglinide | Strong inhibitor |
| 91 | 3A457 | nelfinavir | Strong inhibitor |
| 92 | 3A457 | neratinib | Strong inhibitor |
| 93 | 3A457 | netupitant/palonosetron | Strong inhibitor |
| 94 | 3A457 | nevirapine | Strong inhibitor |
| 95 | 3A457 | nifedipine | Strong inhibitor |
| 96 | 3A457 | nirmatrelvir | Strong inhibitor |
| 97 | 3A457 | nisoldipine | Strong inhibitor |
| 98 | 3A457 | nitrendipine | Strong inhibitor |
| 99 | 3A457 | olaparib | Strong inhibitor |
| 100 | 3A457 | omeprazole | Strong inhibitor |
| 101 | 3A457 | ondansetron | Strong inhibitor |
| 102 | 3A457 | osimertinib | Strong inhibitor |
| 103 | 3A457 | ospemifene | Strong inhibitor |
| 104 | 3A457 | palbociclib | Strong inhibitor |
| 105 | 3A457 | panobinostat | Strong inhibitor |
| 106 | 3A457 | pantoprazole | Strong inhibitor |
| 107 | 3A457 | perampanel | Strong inhibitor |
| 108 | 3A457 | pimavanserin | Strong inhibitor |
| 109 | 3A457 | pimozide | Strong inhibitor |
| 110 | 3A457 | pomalidomide | Strong inhibitor |
| 111 | 3A457 | ponatinib | Strong inhibitor |
| 112 | 3A457 | progesterone | Strong inhibitor |
| 113 | 3A457 | propranolol | Strong inhibitor |
| 114 | 3A457 | quetiapine | Strong inhibitor |
| 115 | 3A457 | quinidine | Strong inhibitor |
| 116 | 3A457 | quinine | Strong inhibitor |
| 117 | 3A457 | regorafenib | Strong inhibitor |
| 118 | 3A457 | ribociclib | Strong inhibitor |
| 119 | 3A457 | rilpivirine | Strong inhibitor |
| 120 | 3A457 | risperidone | Strong inhibitor |
| 121 | 3A457 | ritonavir | Strong inhibitor |
| 122 | 3A457 | rivaroxaban | Strong inhibitor |
| 123 | 3A457 | roflumilast | Strong inhibitor |
| 124 | 3A457 | rolapitant | Strong inhibitor |
| 125 | 3A457 | romidepsin | Strong inhibitor |
| 126 | 3A457 | rucaparib | Strong inhibitor |
| 127 | 3A457 | ruxolitinib | Strong inhibitor |
| 128 | 3A457 | salmeterol | Strong inhibitor |
| 129 | 3A457 | saquinavir | Strong inhibitor |
| 130 | 3A457 | selexipag | Strong inhibitor |
| 131 | 3A457 | sildenafil | Strong inhibitor |
| 132 | 3A457 | simeprevir | Strong inhibitor |
| 133 | 3A457 | simvastatin | Strong inhibitor |
| 134 | 3A457 | sirolimus | Strong inhibitor |
| 135 | 3A457 | sonidegib | Strong inhibitor |
| 136 | 3A457 | sorafenib | Strong inhibitor |
| 137 | 3A457 | sunitinib | Strong inhibitor |
| 138 | 3A457 | suvorexant | Strong inhibitor |
| 139 | 3A457 | tacrolimus(fk506) | Strong inhibitor |
| 140 | 3A457 | tamoxifen | Strong inhibitor |
| 141 | 3A457 | tasimelteon | Strong inhibitor |
| 142 | 3A457 | taxol | Strong inhibitor |
| 143 | 3A457 | telaprevir | Strong inhibitor |
| 144 | 3A457 | telithromycin | Strong inhibitor |
| 145 | 3A457 | terfenadine | Strong inhibitor |
| 146 | 3A457 | testosterone | Strong inhibitor |
| 147 | 3A457 | ticagrelor | Strong inhibitor |
| 148 | 3A457 | tofacitinib | Strong inhibitor |
| 149 | 3A457 | tolvaptan | Strong inhibitor |
| 150 | 3A457 | torisel | Strong inhibitor |
| 151 | 3A457 | tramadol | Strong inhibitor |
| 152 | 3A457 | trazodone | Strong inhibitor |
| 153 | 3A457 | valbenazine | Strong inhibitor |
| 154 | 3A457 | vandetanib | Strong inhibitor |
| 155 | 3A457 | velpatasvir | Strong inhibitor |
| 156 | 3A457 | vemurafenib | Strong inhibitor |
| 157 | 3A457 | venetoclax | Strong inhibitor |
| 158 | 3A457 | venlafaxine | Strong inhibitor |
| 159 | 3A457 | verapamil | Strong inhibitor |
| 160 | 3A457 | vilazodone | Strong inhibitor |
| 161 | 3A457 | vincristine | Strong inhibitor |
| 162 | 3A457 | vorapaxar | Strong inhibitor |
| 163 | 3A457 | voriconazole | Strong inhibitor |
| 164 | 3A457 | zaleplon | Strong inhibitor |
| 165 | 3A457 | ziprasidone | Strong inhibitor |
| 166 | 3A457 | zolpidem | Strong inhibitor |
will
decrease clarithromycin effect
clarithromycin will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.