fluvoxamine
The following drugs will decrease fluvoxamine effect
| # | enzyme | inducers |
| 0 | 1A2 | beta-naphthoflavone |
| 1 | 1A2 | broccoli |
| 2 | 1A2 | brussel sprouts |
| 3 | 1A2 | carbamazepine |
| 4 | 1A2 | char-grilled meat |
| 5 | 1A2 | insulin |
| 6 | 1A2 | methylcholanthrene |
| 7 | 1A2 | modafinil |
| 8 | 1A2 | nafcillin |
| 9 | 1A2 | omeprazole |
| 10 | 1A2 | rifampin |
| 11 | 1A2 | rucaparib |
| 12 | 1A2 | teriflunomide |
| 13 | 1A2 | tobacco |
the follwing drugs will
Increase fluvoxamine effect
| # | enzyme | Inhibitors | level |
| 0 | 2D6 | abiraterone | Moderate inhibitor |
| 1 | 1A2 | amiodarone | |
| 2 | 2D6 | amiodarone | Weak inhibitor |
| 3 | 2D6 | bupropion | Strong inhibitor |
| 4 | 2D6 | celecoxib | Weak inhibitor |
| 5 | 2D6 | chlorpromazine | In-Vitro Only |
| 6 | 1A2 | cimetidine | Weak inhibitor |
| 7 | 2D6 | cimetidine | Weak inhibitor |
| 8 | 2D6 | cinacalcet | Moderate inhibitor |
| 9 | 1A2 | ciprofloxacin | |
| 10 | 1A2 | citalopram | Weak inhibitor |
| 11 | 2D6 | citalopram | Weak inhibitor |
| 12 | 2D6 | clemastine | In-Vitro Only |
| 13 | 2D6 | clobazam | |
| 14 | 2D6 | clomipramine | |
| 15 | 2D6 | cocaine | In-Vitro Only |
| 16 | 2D6 | diphenhydramine | |
| 17 | 2D6 | doxepin | Moderate inhibitor |
| 18 | 2D6 | duloxetine | Moderate inhibitor |
| 19 | 1A2 | efavirenz | Weak inhibitor |
| 20 | 2D6 | escitalopram | |
| 21 | 2D6 | fluoxetine | Strong inhibitor |
| 22 | 1A2 | fluvoxamine | Strong inhibitor |
| 23 | 1A2 | furafylline | In-Vitro Only |
| 24 | 2D6 | halofantrine | Moderate inhibitor |
| 25 | 2D6 | haloperidol | In-Vitro Only |
| 26 | 2D6 | hydroxyzine | In-Vitro Only |
| 27 | 2D6 | levomepromazine | |
| 28 | 2D6 | lorcaserin | Moderate inhibitor |
| 29 | 2D6 | methadone | under review |
| 30 | 1A2 | methoxsalen | In-Vitro Only |
| 31 | 2D6 | metoclopramide | In-Vitro Only |
| 32 | 2D6 | midodrine | |
| 33 | 2D6 | moclobemide | Moderate inhibitor |
| 34 | 2D6 | panobinostat | under review |
| 35 | 2D6 | paroxetine | Strong inhibitor |
| 36 | 2D6 | perphenazine | In-Vitro Only |
| 37 | 2D6 | promethazine | under review |
| 38 | 1A2 | quercetin | Weak inhibitor |
| 39 | 2D6 | quinidine | Strong inhibitor |
| 40 | 1A2 | ribociclib | Weak inhibitor |
| 41 | 2D6 | ritonavir | |
| 42 | 2D6 | rolapitant | Moderate inhibitor |
| 43 | 2D6 | sertraline | |
| 44 | 1A2 | simeprevir | Weak inhibitor |
| 45 | 2D6 | terbinafine (oral) | Moderate inhibitor |
| 46 | 2D6 | ticlopidine | In-Vitro Only |
| 47 | 2D6 | tripelennamine | In-Vitro Only |
| 48 | 1A2 | vemurafenib | Moderate inhibitor |
| 49 | 2D6 | vemurafenib | |
The follwing drugs will Increase effect by fluvoxamine effect
| # | enzyme | drug | level |
| 1 | 3A457 | abemaciclib | under review |
| 2 | 3A457 | abiraterone | under review |
| 3 | 3A457 | acalabrutinib | under review |
| 4 | 1A2 | acetaminophen | Strong inhibitor |
| 5 | 3A457 | alectinib | under review |
| 6 | 3A457 | alfentanil | under review |
| 7 | 3A457 | alprazolam | under review |
| 8 | 2C19 | amitriptyline | Strong inhibitor |
| 9 | 1A2 | amitriptyline | Strong inhibitor |
| 10 | 3A457 | amitriptyline | under review |
| 11 | 2C9 | amitriptyline | In-Vitro Only |
| 12 | 3A457 | amlodipine | under review |
| 13 | 3A457 | apixaban | under review |
| 14 | 1A2 | apremilast | Strong inhibitor |
| 15 | 3A457 | aprepitant | under review |
| 16 | 3A457 | aripiprazole | under review |
| 17 | 3A457 | astemizole | under review |
| 18 | 2C19 | atomoxetine | Strong inhibitor |
| 19 | 3A457 | atorvastatin | under review |
| 20 | 3A457 | avanafil | under review |
| 21 | 3A457 | axitinib | under review |
| 22 | 2C9 | azilsartan | In-Vitro Only |
| 23 | 3A457 | boceprevir | under review |
| 24 | 3A457 | bosutinib | under review |
| 25 | 3A457 | brexpiprazole | under review |
| 26 | 3A457 | brigatinib | under review |
| 27 | 2C19 | brivaracetam | Strong inhibitor |
| 28 | 3A457 | buspirone | under review |
| 29 | 3A457 | cafergot | under review |
| 30 | 1A2 | caffeine | Strong inhibitor |
| 31 | 3A457 | caffeine | under review |
| 32 | 2C9 | capecitabine | In-Vitro Only |
| 33 | 3A457 | carbamazepine | under review |
| 34 | 3A457 | cariprazine | under review |
| 35 | 2C19 | carisoprodol | Strong inhibitor |
| 36 | 2C19 | celecoxib | Strong inhibitor |
| 37 | 2C9 | celecoxib | In-Vitro Only |
| 38 | 3A457 | ceritinib | under review |
| 39 | 3A457 | cerivastatin | under review |
| 40 | 2C19 | chloramphenicol | Strong inhibitor |
| 41 | 3A457 | chlorpheniramine | under review |
| 42 | 3A457 | cilostazol | under review |
| 43 | 3A457 | cisapride | under review |
| 44 | 2C19 | citalopram | Strong inhibitor |
| 45 | 3A457 | citalopram | under review |
| 46 | 3A457 | clarithromycin | under review |
| 47 | 2C19 | clobazam | Strong inhibitor |
| 48 | 3A457 | clobazam | under review |
| 49 | 2C19 | clomipramine | Strong inhibitor |
| 50 | 1A2 | clomipramine | Strong inhibitor |
| 51 | 2C19 | clopidogrel | Strong inhibitor |
| 52 | 3A457 | clopidogrel | under review |
| 53 | 2C9 | clopidogrel | In-Vitro Only |
| 54 | 1A2 | clozapine | Strong inhibitor |
| 55 | 3A457 | cobimetinib | under review |
| 56 | 3A457 | cocaine | under review |
| 57 | 3A457 | codeine | under review |
| 58 | 3A457 | colchicine | under review |
| 59 | 3A457 | copanlisib | under review |
| 60 | 3A457 | crizotinib | under review |
| 61 | 1A2 | cyclobenzaprine | Strong inhibitor |
| 62 | 2C19 | cyclophosphamide | Strong inhibitor |
| 63 | 3A457 | cyclosporine | under review |
| 64 | 3A457 | dabrafenib | under review |
| 65 | 3A457 | daclatasvir | under review |
| 66 | 3A457 | dapsone | under review |
| 67 | 3A457 | deflazacort | under review |
| 68 | 3A457 | dexamethasone | under review |
| 69 | 3A457 | dextromethorphan | under review |
| 70 | 2C19 | diazepam | Strong inhibitor |
| 71 | 3A457 | diazepam | under review |
| 72 | 2C9 | diclofenac | In-Vitro Only |
| 73 | 3A457 | diltiazem | under review |
| 74 | 3A457 | docetaxel | under review |
| 75 | 3A457 | dolutegravir | under review |
| 76 | 3A457 | domperidone | under review |
| 77 | 2C19 | doxepin | Strong inhibitor |
| 78 | 1A2 | doxepin | Strong inhibitor |
| 79 | 3A457 | doxepin | under review |
| 80 | 2C9 | doxepin | In-Vitro Only |
| 81 | 1A2 | duloxetine | Strong inhibitor |
| 82 | 3A457 | elagolix | under review |
| 83 | 3A457 | elbasvir/grazoprevir | under review |
| 84 | 3A457 | eliglustat | under review |
| 85 | 3A457 | enzalutamide | under review |
| 86 | 3A457 | eplerenone | under review |
| 87 | 3A457 | erythromycin2 | under review |
| 88 | 2C19 | escitalopram | Strong inhibitor |
| 89 | 3A457 | escitalopram | under review |
| 90 | 2C19 | esomeprazole | Strong inhibitor |
| 91 | 3A457 | esomeprazole | under review |
| 92 | 1A2 | estradiol | Strong inhibitor |
| 93 | 3A457 | estradiol | under review |
| 94 | 3A457 | felodipine | under review |
| 95 | 3A457 | fentanyl | under review |
| 96 | 3A457 | finasteride | under review |
| 97 | 2C19 | flibanserin | Strong inhibitor |
| 98 | 3A457 | flibanserin | under review |
| 99 | 2C9 | fluoxetine | In-Vitro Only |
| 100 | 2C9 | fluvastatin | In-Vitro Only |
| 101 | 1A2 | fluvoxamine | Strong inhibitor |
| 102 | 3A457 | gleevec | under review |
| 103 | 2C9 | glibenclamide | In-Vitro Only |
| 104 | 2C9 | glimepiride | In-Vitro Only |
| 105 | 2C9 | glipizide | In-Vitro Only |
| 106 | 2C9 | glyburide | In-Vitro Only |
| 107 | 1A2 | haloperidol | Strong inhibitor |
| 108 | 3A457 | haloperidol | under review |
| 109 | 2C19 | hexobarbital | Strong inhibitor |
| 110 | 3A457 | hydrocortisone | under review |
| 111 | 3A457 | ibrutinib | under review |
| 112 | 2C9 | ibuprofen | In-Vitro Only |
| 113 | 3A457 | idelalisib | under review |
| 114 | 2C19 | imipramine | Strong inhibitor |
| 115 | 1A2 | imipramine | Strong inhibitor |
| 116 | 3A457 | indacaterol | under review |
| 117 | 3A457 | indinavir | under review |
| 118 | 2C19 | indomethacin | Strong inhibitor |
| 119 | 2C9 | irbesartan | In-Vitro Only |
| 120 | 3A457 | irinotecan | under review |
| 121 | 3A457 | isavuconazonium | under review |
| 122 | 3A457 | ivabradine | under review |
| 123 | 3A457 | ivacaftor | under review |
| 124 | 3A457 | LAAM | under review |
| 125 | 2C19 | labetalol | Strong inhibitor |
| 126 | 2C19 | lansoprazole | Strong inhibitor |
| 127 | 3A457 | lansoprazole | under review |
| 128 | 3A457 | lenvatinib | under review |
| 129 | 3A457 | lercanidipine | under review |
| 130 | 2C9 | lesinurad | In-Vitro Only |
| 131 | 3A457 | lidocaine | under review |
| 132 | 3A457 | linagliptin | under review |
| 133 | 2C9 | lornoxicam | In-Vitro Only |
| 134 | 2C9 | losartan | In-Vitro Only |
| 135 | 3A457 | lovastatin | under review |
| 136 | 3A457 | macitentan | under review |
| 137 | 2C19 | mavacamten | Strong inhibitor |
| 138 | 3A457 | mavacamten | under review |
| 139 | 2C9 | meloxicam | In-Vitro Only |
| 140 | 3A457 | methadone | under review |
| 141 | 1A2 | mexiletine | Strong inhibitor |
| 142 | 3A457 | midazolam | under review |
| 143 | 2C19 | moclobemide | Strong inhibitor |
| 144 | 1A2 | nabumetone | Strong inhibitor |
| 145 | 3A457 | naldemedine | under review |
| 146 | 3A457 | naloxegol | under review |
| 147 | 1A2 | naproxen | Strong inhibitor |
| 148 | 3A457 | nateglinide | under review |
| 149 | 2C9 | nateglinide | In-Vitro Only |
| 150 | 2C19 | nelfinavir | Strong inhibitor |
| 151 | 3A457 | nelfinavir | under review |
| 152 | 3A457 | neratinib | under review |
| 153 | 3A457 | netupitant/palonosetron | under review |
| 154 | 3A457 | nevirapine | under review |
| 155 | 3A457 | nifedipine | under review |
| 156 | 2C19 | nilutamide | Strong inhibitor |
| 157 | 3A457 | nirmatrelvir | under review |
| 158 | 3A457 | nisoldipine | under review |
| 159 | 3A457 | nitrendipine | under review |
| 160 | 1A2 | olanzapine | Strong inhibitor |
| 161 | 3A457 | olaparib | under review |
| 162 | 2C9 | olodaterol | In-Vitro Only |
| 163 | 2C19 | omeprazole | Strong inhibitor |
| 164 | 3A457 | omeprazole | under review |
| 165 | 1A2 | ondansetron | Strong inhibitor |
| 166 | 3A457 | ondansetron | under review |
| 167 | 3A457 | osimertinib | under review |
| 168 | 2C19 | ospemifene | Strong inhibitor |
| 169 | 3A457 | ospemifene | under review |
| 170 | 2C9 | ospemifene | In-Vitro Only |
| 171 | 3A457 | palbociclib | under review |
| 172 | 3A457 | panobinostat | under review |
| 173 | 2C19 | pantoprazole | Strong inhibitor |
| 174 | 3A457 | pantoprazole | under review |
| 175 | 3A457 | perampanel | under review |
| 176 | 1A2 | phenacetin | Strong inhibitor |
| 177 | 2C19 | phenobarbitone | Strong inhibitor |
| 178 | 2C19 | phenytoin | Strong inhibitor |
| 179 | 2C9 | phenytoin | In-Vitro Only |
| 180 | 3A457 | pimavanserin | under review |
| 181 | 3A457 | pimozide | under review |
| 182 | 1A2 | pirfenidone | Strong inhibitor |
| 183 | 2C9 | piroxicam | In-Vitro Only |
| 184 | 2C19 | pomalidomide | Strong inhibitor |
| 185 | 1A2 | pomalidomide | Strong inhibitor |
| 186 | 3A457 | pomalidomide | under review |
| 187 | 3A457 | ponatinib | under review |
| 188 | 2C19 | primidone | Strong inhibitor |
| 189 | 2C19 | progesterone | Strong inhibitor |
| 190 | 3A457 | progesterone | under review |
| 191 | 2C19 | proguanil | Strong inhibitor |
| 192 | 2C19 | propranolol | Strong inhibitor |
| 193 | 1A2 | propranolol | Strong inhibitor |
| 194 | 3A457 | propranolol | under review |
| 195 | 3A457 | quetiapine | under review |
| 196 | 3A457 | quinidine | under review |
| 197 | 3A457 | quinine | under review |
| 198 | 2C19 | r-mephobarbital | Strong inhibitor |
| 199 | 2C19 | r-warfarin | Strong inhibitor |
| 200 | 3A457 | regorafenib | under review |
| 201 | 3A457 | ribociclib | under review |
| 202 | 3A457 | rilpivirine | under review |
| 203 | 1A2 | riluzole | Strong inhibitor |
| 204 | 3A457 | risperidone | under review |
| 205 | 3A457 | ritonavir | under review |
| 206 | 3A457 | rivaroxaban | under review |
| 207 | 1A2 | roflumilast | Strong inhibitor |
| 208 | 3A457 | roflumilast | under review |
| 209 | 3A457 | rolapitant | under review |
| 210 | 3A457 | romidepsin | under review |
| 211 | 1A2 | ropivacaine | Strong inhibitor |
| 212 | 2C9 | rosiglitazone | In-Vitro Only |
| 213 | 1A2 | rucaparib | Strong inhibitor |
| 214 | 3A457 | rucaparib | under review |
| 215 | 3A457 | ruxolitinib | under review |
| 216 | 2C19 | s-mephenytoin | Strong inhibitor |
| 217 | 2C9 | s-warfarin | In-Vitro Only |
| 218 | 3A457 | salmeterol | under review |
| 219 | 3A457 | saquinavir | under review |
| 220 | 3A457 | selexipag | under review |
| 221 | 3A457 | sildenafil | under review |
| 222 | 3A457 | simeprevir | under review |
| 223 | 3A457 | simvastatin | under review |
| 224 | 3A457 | sirolimus | under review |
| 225 | 3A457 | sonidegib | under review |
| 226 | 3A457 | sorafenib | under review |
| 227 | 3A457 | sunitinib | under review |
| 228 | 2C9 | suprofen | In-Vitro Only |
| 229 | 2C19 | suvorexant | Strong inhibitor |
| 230 | 3A457 | suvorexant | under review |
| 231 | 1A2 | tacrine | Strong inhibitor |
| 232 | 3A457 | tacrolimus(fk506) | under review |
| 233 | 3A457 | tamoxifen | under review |
| 234 | 2C9 | tamoxifen | In-Vitro Only |
| 235 | 1A2 | tasimelteon | Strong inhibitor |
| 236 | 3A457 | tasimelteon | under review |
| 237 | 3A457 | taxol | under review |
| 238 | 3A457 | telaprevir | under review |
| 239 | 3A457 | telithromycin | under review |
| 240 | 2C19 | teniposide | Strong inhibitor |
| 241 | 3A457 | terfenadine | under review |
| 242 | 3A457 | testosterone | under review |
| 243 | 1A2 | theophylline | Strong inhibitor |
| 244 | 3A457 | ticagrelor | under review |
| 245 | 1A2 | tizanidine | Strong inhibitor |
| 246 | 2C19 | tofacitinib | Strong inhibitor |
| 247 | 3A457 | tofacitinib | under review |
| 248 | 2C9 | tolbutamide | In-Vitro Only |
| 249 | 3A457 | tolvaptan | under review |
| 250 | 3A457 | torisel | under review |
| 251 | 2C9 | torsemide | In-Vitro Only |
| 252 | 3A457 | tramadol | under review |
| 253 | 3A457 | trazodone | under review |
| 254 | 1A2 | triamterene | Strong inhibitor |
| 255 | 3A457 | valbenazine | under review |
| 256 | 2C9 | valproic acid | In-Vitro Only |
| 257 | 3A457 | vandetanib | under review |
| 258 | 3A457 | velpatasvir | under review |
| 259 | 3A457 | vemurafenib | under review |
| 260 | 3A457 | venetoclax | under review |
| 261 | 2C19 | venlafaxine | Strong inhibitor |
| 262 | 3A457 | venlafaxine | under review |
| 263 | 2C9 | venlafaxine | In-Vitro Only |
| 264 | 1A2 | verapamil | Strong inhibitor |
| 265 | 3A457 | verapamil | under review |
| 266 | 2C19 | vilazodone | Strong inhibitor |
| 267 | 3A457 | vilazodone | under review |
| 268 | 3A457 | vincristine | under review |
| 269 | 3A457 | vorapaxar | under review |
| 270 | 2C19 | voriconazole | Strong inhibitor |
| 271 | 3A457 | voriconazole | under review |
| 272 | 2C9 | voriconazole | In-Vitro Only |
| 273 | 1A2 | warfarin | Strong inhibitor |
| 274 | 2C9 | zafirlukast | In-Vitro Only |
| 275 | 3A457 | zaleplon | under review |
| 276 | 1A2 | zileuton | Strong inhibitor |
| 277 | 3A457 | ziprasidone | under review |
| 278 | 1A2 | zolmitriptan | Strong inhibitor |
| 279 | 3A457 | zolpidem | under review |
will
decrease fluvoxamine effect
fluvoxamine will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.