carbamazepine
The following drugs will decrease carbamazepine effect
# | enzyme | inducers |
0 | 3A457 | barbiturates |
1 | 3A457 | brigatinib |
2 | 3A457 | carbamazepine |
3 | 3A457 | clobazam |
4 | 3A457 | dabrafenib |
5 | 3A457 | efavirenz |
6 | 3A457 | elagolix |
7 | 3A457 | enzalutamide |
8 | 3A457 | eslicarbazepine |
9 | 3A457 | glucocorticoids |
10 | 3A457 | letermovir |
11 | 3A457 | lorlatinib |
12 | 3A457 | modafinil |
13 | 3A457 | nevirapine |
14 | 3A457 | oxcarbazepine |
15 | 3A457 | perampanel |
16 | 3A457 | phenobarbital |
17 | 3A457 | phenytoin |
18 | 3A457 | pioglitazone |
19 | 3A457 | rifabutin |
20 | 3A457 | rifampin |
21 | 3A457 | St. John's Wort |
22 | 3A457 | telotristat |
23 | 3A457 | troglitazone |
24 | 3A457 | vemurafenib |
the follwing drugs will
Increase carbamazepine effect
# | enzyme | Inhibitors | level |
0 | 3A457 | amiodarone | under review |
1 | 3A457 | aprepitant | Moderate inhibitor |
2 | 3A457 | atomoxetine | |
3 | 3A457 | boceprevir | under review |
4 | 3A457 | ceritinib | Strong inhibitor |
5 | 3A457 | chloramphenicol | In-Vitro Only |
6 | 3A457 | cimetidine | |
7 | 3A457 | ciprofloxacin | under review |
8 | 3A457 | clarithromycin | Strong inhibitor |
9 | 3A457 | crizotinib | Moderate inhibitor |
10 | 3A457 | delaviridine | under review |
11 | 3A457 | diethyl-dithiocarbamate | |
12 | 3A457 | diltiazem | Moderate inhibitor |
13 | 3A457 | entrectinib | |
14 | 3A457 | erythromycin | Moderate inhibitor |
15 | 3A457 | esomeprazole | |
16 | 3A457 | fluconazole | Moderate inhibitor |
17 | 3A457 | fluvoxamine | under review |
18 | 3A457 | gestodene | under review |
19 | 3A457 | grapefruit juice | Moderate inhibitor |
20 | 3A457 | idelalisib | Strong inhibitor |
21 | 3A457 | imatinib | under review |
22 | 3A457 | indinavir | Strong inhibitor |
23 | 3A457 | itraconazole | Strong inhibitor |
24 | 3A457 | ivacaftor | |
25 | 3A457 | ketoconazole | Strong inhibitor |
26 | 3A457 | lesinurad | |
27 | 3A457 | letermovir | |
28 | 3A457 | mibefradil | Strong inhibitor |
29 | 3A457 | mifepristone | under review |
30 | 3A457 | nefazodone | Strong inhibitor |
31 | 3A457 | nelfinavir | Strong inhibitor |
32 | 3A457 | netupitant/palonosetron | Moderate inhibitor |
33 | 3A457 | norfloxacin | under review |
34 | 3A457 | norfluoxetine | under review |
35 | 3A457 | omeprazole | Weak inhibitor |
36 | 3A457 | pantoprazole | |
37 | 3A457 | perampanel | |
38 | 3A457 | quercetin | |
39 | 3A457 | regorafenib | under review |
40 | 3A457 | ribociclib | Strong inhibitor |
41 | 3A457 | ritonavir | Strong inhibitor |
42 | 3A457 | rucaparib | |
43 | 3A457 | saquinavir | Strong inhibitor |
44 | 3A457 | simeprevir | |
45 | 3A457 | starfruit | under review |
46 | 3A457 | telaprevir | under review |
47 | 3A457 | telithromycin | Strong inhibitor |
48 | 3A457 | ticagrelor | |
49 | 3A457 | tucatinib | Strong inhibitor |
50 | 3A457 | verapamil | Moderate inhibitor |
51 | 3A457 | voriconazole | Strong inhibitor |
The following drugs will decreased effect by carbamazepine effect
# | enzyme | drug |
1 | 3A457 | abemaciclib |
2 | 3A457 | abiraterone |
3 | 3A457 | acalabrutinib |
4 | 1A2 | acetaminophen |
5 | 3A457 | alectinib |
6 | 3A457 | alfentanil |
7 | 3A457 | alprazolam |
8 | 1A2 | amitriptyline |
9 | 2C19 | amitriptyline |
10 | 2C9 | amitriptyline |
11 | 3A457 | amitriptyline |
12 | 3A457 | amlodipine |
13 | 3A457 | apixaban |
14 | 1A2 | apremilast |
15 | 3A457 | aprepitant |
16 | 3A457 | aripiprazole |
17 | 2B6 | artemisinin |
18 | 3A457 | astemizole |
19 | 2C19 | atomoxetine |
20 | 3A457 | atorvastatin |
21 | 3A457 | avanafil |
22 | 3A457 | axitinib |
23 | 2C9 | azilsartan |
24 | 3A457 | boceprevir |
25 | 3A457 | bosutinib |
26 | 3A457 | brexpiprazole |
27 | 3A457 | brigatinib |
28 | 2C19 | brivaracetam |
29 | 2B6 | bupropion |
30 | 3A457 | buspirone |
31 | 3A457 | cafergot |
32 | 1A2 | caffeine |
33 | 3A457 | caffeine |
34 | 2C9 | capecitabine |
35 | 3A457 | carbamazepine |
36 | 3A457 | cariprazine |
37 | 2C19 | carisoprodol |
38 | 2C19 | celecoxib |
39 | 2C9 | celecoxib |
40 | 3A457 | ceritinib |
41 | 3A457 | cerivastatin |
42 | 2C19 | chloramphenicol |
43 | 3A457 | chlorpheniramine |
44 | 3A457 | cilostazol |
45 | 3A457 | cisapride |
46 | 2C19 | citalopram |
47 | 3A457 | citalopram |
48 | 3A457 | clarithromycin |
49 | 2B6 | clobazam |
50 | 2C19 | clobazam |
51 | 3A457 | clobazam |
52 | 1A2 | clomipramine |
53 | 2C19 | clomipramine |
54 | 2C19 | clopidogrel |
55 | 2C9 | clopidogrel |
56 | 3A457 | clopidogrel |
57 | 1A2 | clozapine |
58 | 3A457 | cobimetinib |
59 | 3A457 | cocaine |
60 | 3A457 | codeine |
61 | 3A457 | colchicine |
62 | 3A457 | copanlisib |
63 | 3A457 | crizotinib |
64 | 1A2 | cyclobenzaprine |
65 | 2B6 | cyclophosphamide |
66 | 2C19 | cyclophosphamide |
67 | 3A457 | cyclosporine |
68 | 3A457 | dabrafenib |
69 | 3A457 | daclatasvir |
70 | 3A457 | dapsone |
71 | 3A457 | deflazacort |
72 | 3A457 | dexamethasone |
73 | 3A457 | dextromethorphan |
74 | 2C19 | diazepam |
75 | 3A457 | diazepam |
76 | 2C9 | diclofenac |
77 | 3A457 | diltiazem |
78 | 3A457 | docetaxel |
79 | 3A457 | dolutegravir |
80 | 3A457 | domperidone |
81 | 1A2 | doxepin |
82 | 2C19 | doxepin |
83 | 2C9 | doxepin |
84 | 3A457 | doxepin |
85 | 1A2 | duloxetine |
86 | 2B6 | efavirenz |
87 | 3A457 | elagolix |
88 | 3A457 | elbasvir/grazoprevir |
89 | 3A457 | eliglustat |
90 | 3A457 | enzalutamide |
91 | 3A457 | eplerenone |
92 | 3A457 | erythromycin2 |
93 | 2C19 | escitalopram |
94 | 3A457 | escitalopram |
95 | 2C19 | esomeprazole |
96 | 3A457 | esomeprazole |
97 | 1A2 | estradiol |
98 | 3A457 | estradiol |
99 | 3A457 | felodipine |
100 | 3A457 | fentanyl |
101 | 3A457 | finasteride |
102 | 2C19 | flibanserin |
103 | 3A457 | flibanserin |
104 | 2C9 | fluoxetine |
105 | 2C9 | fluvastatin |
106 | 1A2 | fluvoxamine |
107 | 3A457 | gleevec |
108 | 2C9 | glibenclamide |
109 | 2C9 | glimepiride |
110 | 2C9 | glipizide |
111 | 2C9 | glyburide |
112 | 1A2 | haloperidol |
113 | 3A457 | haloperidol |
114 | 2C19 | hexobarbital |
115 | 3A457 | hydrocortisone |
116 | 3A457 | ibrutinib |
117 | 2C9 | ibuprofen |
118 | 3A457 | idelalisib |
119 | 2B6 | ifosphamide |
120 | 1A2 | imipramine |
121 | 2C19 | imipramine |
122 | 3A457 | indacaterol |
123 | 3A457 | indinavir |
124 | 2C19 | indomethacin |
125 | 2C9 | irbesartan |
126 | 3A457 | irinotecan |
127 | 3A457 | isavuconazonium |
128 | 3A457 | ivabradine |
129 | 3A457 | ivacaftor |
130 | 2B6 | ketamine |
131 | 3A457 | LAAM |
132 | 2C19 | labetalol |
133 | 2C19 | lansoprazole |
134 | 3A457 | lansoprazole |
135 | 3A457 | lenvatinib |
136 | 3A457 | lercanidipine |
137 | 2C9 | lesinurad |
138 | 3A457 | lidocaine |
139 | 3A457 | linagliptin |
140 | 2C9 | lornoxicam |
141 | 2C9 | losartan |
142 | 3A457 | lovastatin |
143 | 3A457 | macitentan |
144 | 2C19 | mavacamten |
145 | 3A457 | mavacamten |
146 | 2C9 | meloxicam |
147 | 2B6 | meperidine |
148 | 2B6 | methadone |
149 | 3A457 | methadone |
150 | 1A2 | mexiletine |
151 | 3A457 | midazolam |
152 | 2C19 | moclobemide |
153 | 1A2 | nabumetone |
154 | 3A457 | naldemedine |
155 | 3A457 | naloxegol |
156 | 1A2 | naproxen |
157 | 2C9 | nateglinide |
158 | 3A457 | nateglinide |
159 | 2C19 | nelfinavir |
160 | 3A457 | nelfinavir |
161 | 3A457 | neratinib |
162 | 3A457 | netupitant/palonosetron |
163 | 2B6 | nevirapine |
164 | 3A457 | nevirapine |
165 | 3A457 | nifedipine |
166 | 2C19 | nilutamide |
167 | 3A457 | nirmatrelvir |
168 | 3A457 | nisoldipine |
169 | 3A457 | nitrendipine |
170 | 1A2 | olanzapine |
171 | 3A457 | olaparib |
172 | 2C9 | olodaterol |
173 | 2C19 | omeprazole |
174 | 3A457 | omeprazole |
175 | 1A2 | ondansetron |
176 | 3A457 | ondansetron |
177 | 3A457 | osimertinib |
178 | 2C19 | ospemifene |
179 | 2C9 | ospemifene |
180 | 3A457 | ospemifene |
181 | 3A457 | palbociclib |
182 | 3A457 | panobinostat |
183 | 2C19 | pantoprazole |
184 | 3A457 | pantoprazole |
185 | 3A457 | perampanel |
186 | 1A2 | phenacetin |
187 | 2C19 | phenobarbitone |
188 | 2C19 | phenytoin |
189 | 2C9 | phenytoin |
190 | 3A457 | pimavanserin |
191 | 3A457 | pimozide |
192 | 1A2 | pirfenidone |
193 | 2C9 | piroxicam |
194 | 1A2 | pomalidomide |
195 | 2C19 | pomalidomide |
196 | 3A457 | pomalidomide |
197 | 3A457 | ponatinib |
198 | 2C19 | primidone |
199 | 2C19 | progesterone |
200 | 3A457 | progesterone |
201 | 2C19 | proguanil |
202 | 2B6 | propafol |
203 | 1A2 | propranolol |
204 | 2C19 | propranolol |
205 | 3A457 | propranolol |
206 | 3A457 | quetiapine |
207 | 3A457 | quinidine |
208 | 3A457 | quinine |
209 | 2C19 | r-mephobarbital |
210 | 2C19 | r-warfarin |
211 | 3A457 | regorafenib |
212 | 3A457 | ribociclib |
213 | 3A457 | rilpivirine |
214 | 1A2 | riluzole |
215 | 3A457 | risperidone |
216 | 3A457 | ritonavir |
217 | 3A457 | rivaroxaban |
218 | 1A2 | roflumilast |
219 | 3A457 | roflumilast |
220 | 3A457 | rolapitant |
221 | 3A457 | romidepsin |
222 | 1A2 | ropivacaine |
223 | 2C9 | rosiglitazone |
224 | 1A2 | rucaparib |
225 | 3A457 | rucaparib |
226 | 3A457 | ruxolitinib |
227 | 2C19 | s-mephenytoin |
228 | 2C9 | s-warfarin |
229 | 3A457 | salmeterol |
230 | 3A457 | saquinavir |
231 | 2B6 | selegiline |
232 | 3A457 | selexipag |
233 | 3A457 | sildenafil |
234 | 3A457 | simeprevir |
235 | 3A457 | simvastatin |
236 | 3A457 | sirolimus |
237 | 3A457 | sonidegib |
238 | 2B6 | sorafenib |
239 | 3A457 | sorafenib |
240 | 3A457 | sunitinib |
241 | 2C9 | suprofen |
242 | 2C19 | suvorexant |
243 | 3A457 | suvorexant |
244 | 1A2 | tacrine |
245 | 3A457 | tacrolimus(fk506) |
246 | 2C9 | tamoxifen |
247 | 3A457 | tamoxifen |
248 | 1A2 | tasimelteon |
249 | 3A457 | tasimelteon |
250 | 3A457 | taxol |
251 | 3A457 | telaprevir |
252 | 3A457 | telithromycin |
253 | 2C19 | teniposide |
254 | 3A457 | terfenadine |
255 | 3A457 | testosterone |
256 | 1A2 | theophylline |
257 | 3A457 | ticagrelor |
258 | 1A2 | tizanidine |
259 | 2C19 | tofacitinib |
260 | 3A457 | tofacitinib |
261 | 2C9 | tolbutamide |
262 | 3A457 | tolvaptan |
263 | 3A457 | torisel |
264 | 2C9 | torsemide |
265 | 2B6 | tramadol |
266 | 3A457 | tramadol |
267 | 3A457 | trazodone |
268 | 1A2 | triamterene |
269 | 3A457 | valbenazine |
270 | 2C9 | valproic acid |
271 | 3A457 | vandetanib |
272 | 2B6 | velpatasvir |
273 | 3A457 | velpatasvir |
274 | 3A457 | vemurafenib |
275 | 3A457 | venetoclax |
276 | 2C19 | venlafaxine |
277 | 2C9 | venlafaxine |
278 | 3A457 | venlafaxine |
279 | 1A2 | verapamil |
280 | 3A457 | verapamil |
281 | 2C19 | vilazodone |
282 | 3A457 | vilazodone |
283 | 3A457 | vincristine |
284 | 3A457 | vorapaxar |
285 | 2C19 | voriconazole |
286 | 2C9 | voriconazole |
287 | 3A457 | voriconazole |
288 | 1A2 | warfarin |
289 | 2C9 | zafirlukast |
290 | 3A457 | zaleplon |
291 | 1A2 | zileuton |
292 | 3A457 | ziprasidone |
293 | 1A2 | zolmitriptan |
294 | 3A457 | zolpidem |
will
decrease carbamazepine effect
carbamazepine will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.