The following drugs will decrease tucatinib effect

#	enzyme	inducers
0	2C8	rifampin

the follwing drugs will Increase tucatinib effect

#	enzyme	Inhibitors	level
0	2C8	abiraterone	Weak inhibitor
1	2C8	clopidogrel	Weak inhibitor
2	2C8	deferasirox	Moderate inhibitor
3	2C8	gemfibrozil	Strong inhibitor
4	2C8	glitazones	In-Vitro Only
5	2C8	lapatinib	Weak inhibitor
6	2C8	letermovir	In-Vitro Only
7	2C8	montelukast	In-Vitro Only
8	2C8	perampanel	In-Vitro Only
9	2C8	quercetin	In-Vitro Only
10	2C8	teriflunomide	Moderate inhibitor
11	2C8	trimethoprim	Moderate inhibitor
12	2C8	tucatinib	Weak inhibitor

The follwing drugs will Increase effect by tucatinib effect

#	enzyme	drug	level
1	3A457	abemaciclib	Strong inhibitor
2	3A457	abiraterone	Strong inhibitor
3	3A457	acalabrutinib	Strong inhibitor
4	3A457	alectinib	Strong inhibitor
5	3A457	alfentanil	Strong inhibitor
6	3A457	alprazolam	Strong inhibitor
7	3A457	amitriptyline	Strong inhibitor
8	3A457	amlodipine	Strong inhibitor
9	2C8	amodiaquine	Weak inhibitor
10	3A457	apixaban	Strong inhibitor
11	3A457	aprepitant	Strong inhibitor
12	3A457	aripiprazole	Strong inhibitor
13	3A457	astemizole	Strong inhibitor
14	3A457	atorvastatin	Strong inhibitor
15	3A457	avanafil	Strong inhibitor
16	3A457	axitinib	Strong inhibitor
17	3A457	boceprevir	Strong inhibitor
18	3A457	bosutinib	Strong inhibitor
19	3A457	brexpiprazole	Strong inhibitor
20	3A457	brigatinib	Strong inhibitor
21	3A457	buspirone	Strong inhibitor
22	3A457	cafergot	Strong inhibitor
23	3A457	caffeine	Strong inhibitor
24	3A457	carbamazepine	Strong inhibitor
25	3A457	cariprazine	Strong inhibitor
26	3A457	ceritinib	Strong inhibitor
27	2C8	cerivastatin	Weak inhibitor
28	3A457	cerivastatin	Strong inhibitor
29	3A457	chlorpheniramine	Strong inhibitor
30	3A457	cilostazol	Strong inhibitor
31	3A457	cisapride	Strong inhibitor
32	3A457	citalopram	Strong inhibitor
33	3A457	clarithromycin	Strong inhibitor
34	3A457	clobazam	Strong inhibitor
35	3A457	clopidogrel	Strong inhibitor
36	3A457	cobimetinib	Strong inhibitor
37	3A457	cocaine	Strong inhibitor
38	3A457	codeine	Strong inhibitor
39	3A457	colchicine	Strong inhibitor
40	3A457	copanlisib	Strong inhibitor
41	3A457	crizotinib	Strong inhibitor
42	3A457	cyclosporine	Strong inhibitor
43	2C8	dabrafenib	Weak inhibitor
44	3A457	dabrafenib	Strong inhibitor
45	3A457	daclatasvir	Strong inhibitor
46	3A457	dapsone	Strong inhibitor
47	3A457	deflazacort	Strong inhibitor
48	3A457	dexamethasone	Strong inhibitor
49	3A457	dextromethorphan	Strong inhibitor
50	3A457	diazepam	Strong inhibitor
51	3A457	diltiazem	Strong inhibitor
52	3A457	docetaxel	Strong inhibitor
53	3A457	dolutegravir	Strong inhibitor
54	3A457	domperidone	Strong inhibitor
55	3A457	doxepin	Strong inhibitor
56	3A457	elagolix	Strong inhibitor
57	3A457	elbasvir/grazoprevir	Strong inhibitor
58	3A457	eliglustat	Strong inhibitor
59	2C8	enzalutamide	Weak inhibitor
60	3A457	enzalutamide	Strong inhibitor
61	3A457	eplerenone	Strong inhibitor
62	3A457	erythromycin2	Strong inhibitor
63	3A457	escitalopram	Strong inhibitor
64	3A457	esomeprazole	Strong inhibitor
65	3A457	estradiol	Strong inhibitor
66	3A457	felodipine	Strong inhibitor
67	3A457	fentanyl	Strong inhibitor
68	3A457	finasteride	Strong inhibitor
69	3A457	flibanserin	Strong inhibitor
70	3A457	gleevec	Strong inhibitor
71	3A457	haloperidol	Strong inhibitor
72	3A457	hydrocortisone	Strong inhibitor
73	3A457	ibrutinib	Strong inhibitor
74	3A457	idelalisib	Strong inhibitor
75	3A457	indacaterol	Strong inhibitor
76	3A457	indinavir	Strong inhibitor
77	3A457	irinotecan	Strong inhibitor
78	3A457	isavuconazonium	Strong inhibitor
79	3A457	ivabradine	Strong inhibitor
80	3A457	ivacaftor	Strong inhibitor
81	3A457	LAAM	Strong inhibitor
82	3A457	lansoprazole	Strong inhibitor
83	3A457	lenvatinib	Strong inhibitor
84	3A457	lercanidipine	Strong inhibitor
85	3A457	lidocaine	Strong inhibitor
86	3A457	linagliptin	Strong inhibitor
87	3A457	lovastatin	Strong inhibitor
88	3A457	macitentan	Strong inhibitor
89	3A457	mavacamten	Strong inhibitor
90	3A457	methadone	Strong inhibitor
91	3A457	midazolam	Strong inhibitor
92	3A457	naldemedine	Strong inhibitor
93	3A457	naloxegol	Strong inhibitor
94	3A457	nateglinide	Strong inhibitor
95	3A457	nelfinavir	Strong inhibitor
96	3A457	neratinib	Strong inhibitor
97	3A457	netupitant/palonosetron	Strong inhibitor
98	3A457	nevirapine	Strong inhibitor
99	3A457	nifedipine	Strong inhibitor
100	3A457	nirmatrelvir	Strong inhibitor
101	3A457	nisoldipine	Strong inhibitor
102	3A457	nitrendipine	Strong inhibitor
103	3A457	olaparib	Strong inhibitor
104	2C8	olodaterol	Weak inhibitor
105	3A457	omeprazole	Strong inhibitor
106	3A457	ondansetron	Strong inhibitor
107	3A457	osimertinib	Strong inhibitor
108	3A457	ospemifene	Strong inhibitor
109	2C8	paclitaxel	Weak inhibitor
110	3A457	palbociclib	Strong inhibitor
111	3A457	panobinostat	Strong inhibitor
112	3A457	pantoprazole	Strong inhibitor
113	3A457	perampanel	Strong inhibitor
114	3A457	pimavanserin	Strong inhibitor
115	3A457	pimozide	Strong inhibitor
116	3A457	pomalidomide	Strong inhibitor
117	2C8	ponatinib	Weak inhibitor
118	3A457	ponatinib	Strong inhibitor
119	3A457	progesterone	Strong inhibitor
120	3A457	propranolol	Strong inhibitor
121	3A457	quetiapine	Strong inhibitor
122	3A457	quinidine	Strong inhibitor
123	3A457	quinine	Strong inhibitor
124	3A457	regorafenib	Strong inhibitor
125	2C8	repaglinide	Weak inhibitor
126	3A457	ribociclib	Strong inhibitor
127	3A457	rilpivirine	Strong inhibitor
128	3A457	risperidone	Strong inhibitor
129	3A457	ritonavir	Strong inhibitor
130	3A457	rivaroxaban	Strong inhibitor
131	3A457	roflumilast	Strong inhibitor
132	3A457	rolapitant	Strong inhibitor
133	3A457	romidepsin	Strong inhibitor
134	3A457	rucaparib	Strong inhibitor
135	3A457	ruxolitinib	Strong inhibitor
136	3A457	salmeterol	Strong inhibitor
137	3A457	saquinavir	Strong inhibitor
138	2C8	selexipag	Weak inhibitor
139	3A457	selexipag	Strong inhibitor
140	3A457	sildenafil	Strong inhibitor
141	3A457	simeprevir	Strong inhibitor
142	3A457	simvastatin	Strong inhibitor
143	3A457	sirolimus	Strong inhibitor
144	3A457	sonidegib	Strong inhibitor
145	2C8	sorafenib	Weak inhibitor
146	3A457	sorafenib	Strong inhibitor
147	3A457	sunitinib	Strong inhibitor
148	3A457	suvorexant	Strong inhibitor
149	3A457	tacrolimus(fk506)	Strong inhibitor
150	3A457	tamoxifen	Strong inhibitor
151	3A457	tasimelteon	Strong inhibitor
152	3A457	taxol	Strong inhibitor
153	3A457	telaprevir	Strong inhibitor
154	3A457	telithromycin	Strong inhibitor
155	3A457	terfenadine	Strong inhibitor
156	3A457	testosterone	Strong inhibitor
157	3A457	ticagrelor	Strong inhibitor
158	3A457	tofacitinib	Strong inhibitor
159	3A457	tolvaptan	Strong inhibitor
160	3A457	torisel	Strong inhibitor
161	2C8	torsemide	Weak inhibitor
162	3A457	tramadol	Strong inhibitor
163	3A457	trazodone	Strong inhibitor
164	2C8	tucatinib	Weak inhibitor
165	3A457	valbenazine	Strong inhibitor
166	3A457	vandetanib	Strong inhibitor
167	3A457	velpatasvir	Strong inhibitor
168	3A457	vemurafenib	Strong inhibitor
169	3A457	venetoclax	Strong inhibitor
170	3A457	venlafaxine	Strong inhibitor
171	3A457	verapamil	Strong inhibitor
172	3A457	vilazodone	Strong inhibitor
173	3A457	vincristine	Strong inhibitor
174	3A457	vorapaxar	Strong inhibitor
175	3A457	voriconazole	Strong inhibitor
176	3A457	zaleplon	Strong inhibitor
177	3A457	ziprasidone	Strong inhibitor
178	3A457	zolpidem	Strong inhibitor

will decrease tucatinib effect

#

enzyme

inducers

tucatinib will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.