The following drugs will decrease voriconazole effect

#	enzyme	inducers
0	2C9	carbamazepine
1	3A457	barbiturates
2	3A457	brigatinib
3	2C19	carbamazepine
4	3A457	carbamazepine
5	3A457	clobazam
6	2C9	dabrafenib
7	2C9	enzalutamide
8	3A457	dabrafenib
9	2C19	efavirenz
10	3A457	efavirenz
11	2C19	enzalutamide
12	3A457	elagolix
13	3A457	enzalutamide
14	2C19	letermovir
15	3A457	eslicarbazepine
16	3A457	glucocorticoids
17	3A457	letermovir
18	3A457	lorlatinib
19	3A457	modafinil
20	2C9	letermovir
21	3A457	nevirapine
22	3A457	oxcarbazepine
23	2C19	norethindrone
24	3A457	perampanel
25	2C19	prednisone
26	2C9	nevirapine
27	2C9	phenobarbital
28	2C19	rifampicin
29	3A457	phenobarbital
30	2C19	ritonavir
31	2C9	rifampin
32	2C9	secobarbital
33	3A457	phenytoin
34	3A457	pioglitazone
35	3A457	rifabutin
36	3A457	rifampin
37	3A457	St. John's Wort
38	3A457	telotristat
39	3A457	troglitazone
40	3A457	vemurafenib

the follwing drugs will Increase voriconazole effect

#	enzyme	Inhibitors	level
0	2C9	amiodarone	Moderate inhibitor
1	3A457	amiodarone	under review
2	3A457	aprepitant	Moderate inhibitor
3	2C19	armodafinil	Weak inhibitor
4	3A457	atomoxetine
5	3A457	boceprevir	under review
6	2C9	capecitabine	Weak inhibitor
7	2C9	ceritinib	Weak inhibitor
8	3A457	ceritinib	Strong inhibitor
9	2C19	chloramphenicol	In-Vitro Only
10	3A457	chloramphenicol	In-Vitro Only
11	2C19	cimetidine	Weak inhibitor
12	3A457	cimetidine
13	3A457	ciprofloxacin	under review
14	2C19	citalopram	Weak inhibitor
15	3A457	clarithromycin	Strong inhibitor
16	3A457	crizotinib	Moderate inhibitor
17	3A457	delaviridine	under review
18	3A457	diethyl-dithiocarbamate
19	3A457	diltiazem	Moderate inhibitor
20	2C9	efavirenz	Weak inhibitor
21	3A457	entrectinib
22	3A457	erythromycin	Moderate inhibitor
23	2C19	esomeprazole	Weak inhibitor
24	3A457	esomeprazole
25	2C19	felbamate	Weak inhibitor
26	2C9	fenofibrate	In-Vitro Only
27	2C9	fluconazole	Moderate inhibitor
28	2C19	fluconazole	Moderate inhibitor
29	3A457	fluconazole	Moderate inhibitor
30	2C19	fluoxetine	Moderate inhibitor
31	2C9	fluvastatin	In-Vitro Only
32	2C9	fluvoxamine	In-Vitro Only
33	2C19	fluvoxamine	Strong inhibitor
34	3A457	fluvoxamine	under review
35	3A457	gestodene	under review
36	3A457	grapefruit juice	Moderate inhibitor
37	3A457	idelalisib	Strong inhibitor
38	3A457	imatinib	under review
39	3A457	indinavir	Strong inhibitor
40	2C9	isoniazid	Weak inhibitor
41	2C19	isoniazid	Weak inhibitor
42	3A457	itraconazole	Strong inhibitor
43	3A457	ivacaftor
44	2C19	ketoconazole	Moderate inhibitor
45	3A457	ketoconazole	Strong inhibitor
46	3A457	lesinurad
47	3A457	letermovir
48	2C19	luliconazole	Weak inhibitor
49	2C9	metronidazole	Moderate inhibitor
50	3A457	mibefradil	Strong inhibitor
51	3A457	mifepristone	under review
52	2C19	modafinil	Weak inhibitor
53	3A457	nefazodone	Strong inhibitor
54	3A457	nelfinavir	Strong inhibitor
55	3A457	netupitant/palonosetron	Moderate inhibitor
56	3A457	norfloxacin	under review
57	3A457	norfluoxetine	under review
58	2C19	omeprazole	Weak inhibitor
59	3A457	omeprazole	Weak inhibitor
60	2C19	oral contraceptives	Weak inhibitor
61	2C19	oritavancin	In-Vitro Only
62	2C19	pantoprazole	Weak inhibitor
63	3A457	pantoprazole
64	3A457	perampanel
65	2C9	phenylbutazone	Moderate inhibitor
66	2C9	quercetin	Weak inhibitor
67	2C19	quercetin	In-Vitro Only
68	3A457	quercetin
69	3A457	regorafenib	under review
70	3A457	ribociclib	Strong inhibitor
71	3A457	ritonavir	Strong inhibitor
72	3A457	rucaparib
73	3A457	saquinavir	Strong inhibitor
74	3A457	simeprevir
75	3A457	starfruit	under review
76	2C9	sulfamethoxazole	Weak inhibitor
77	2C9	sulfaphenazole	Strong inhibitor
78	3A457	telaprevir	under review
79	3A457	telithromycin	Strong inhibitor
80	3A457	ticagrelor
81	2C19	ticlopidine	Strong inhibitor
82	2C19	topiramate	under review
83	3A457	tucatinib	Strong inhibitor
84	3A457	verapamil	Moderate inhibitor
85	2C19	voriconazole	Moderate inhibitor
86	3A457	voriconazole	Strong inhibitor
87	2C9	zafirlukast	Weak inhibitor

The follwing drugs will Increase effect by voriconazole effect

#	enzyme	drug	level
1	3A457	abemaciclib	Strong inhibitor
2	3A457	abiraterone	Strong inhibitor
3	3A457	acalabrutinib	Strong inhibitor
4	3A457	alectinib	Strong inhibitor
5	3A457	alfentanil	Strong inhibitor
6	3A457	alprazolam	Strong inhibitor
7	2C19	amitriptyline	Moderate inhibitor
8	2C9	amitriptyline	Weak inhibitor
9	3A457	amitriptyline	Strong inhibitor
10	3A457	amlodipine	Strong inhibitor
11	3A457	apixaban	Strong inhibitor
12	3A457	aprepitant	Strong inhibitor
13	3A457	aripiprazole	Strong inhibitor
14	2B6	artemisinin	Moderate inhibitor
15	3A457	astemizole	Strong inhibitor
16	2C19	atomoxetine	Moderate inhibitor
17	3A457	atorvastatin	Strong inhibitor
18	3A457	avanafil	Strong inhibitor
19	3A457	axitinib	Strong inhibitor
20	2C9	azilsartan	Weak inhibitor
21	3A457	boceprevir	Strong inhibitor
22	3A457	bosutinib	Strong inhibitor
23	3A457	brexpiprazole	Strong inhibitor
24	3A457	brigatinib	Strong inhibitor
25	2C19	brivaracetam	Moderate inhibitor
26	2B6	bupropion	Moderate inhibitor
27	3A457	buspirone	Strong inhibitor
28	3A457	cafergot	Strong inhibitor
29	3A457	caffeine	Strong inhibitor
30	2C9	capecitabine	Weak inhibitor
31	3A457	carbamazepine	Strong inhibitor
32	3A457	cariprazine	Strong inhibitor
33	2C19	carisoprodol	Moderate inhibitor
34	2C19	celecoxib	Moderate inhibitor
35	2C9	celecoxib	Weak inhibitor
36	3A457	ceritinib	Strong inhibitor
37	3A457	cerivastatin	Strong inhibitor
38	2C19	chloramphenicol	Moderate inhibitor
39	3A457	chlorpheniramine	Strong inhibitor
40	3A457	cilostazol	Strong inhibitor
41	3A457	cisapride	Strong inhibitor
42	2C19	citalopram	Moderate inhibitor
43	3A457	citalopram	Strong inhibitor
44	3A457	clarithromycin	Strong inhibitor
45	2C19	clobazam	Moderate inhibitor
46	3A457	clobazam	Strong inhibitor
47	2B6	clobazam	Moderate inhibitor
48	2C19	clomipramine	Moderate inhibitor
49	2C19	clopidogrel	Moderate inhibitor
50	2C9	clopidogrel	Weak inhibitor
51	3A457	clopidogrel	Strong inhibitor
52	3A457	cobimetinib	Strong inhibitor
53	3A457	cocaine	Strong inhibitor
54	3A457	codeine	Strong inhibitor
55	3A457	colchicine	Strong inhibitor
56	3A457	copanlisib	Strong inhibitor
57	3A457	crizotinib	Strong inhibitor
58	2C19	cyclophosphamide	Moderate inhibitor
59	2B6	cyclophosphamide	Moderate inhibitor
60	3A457	cyclosporine	Strong inhibitor
61	3A457	dabrafenib	Strong inhibitor
62	3A457	daclatasvir	Strong inhibitor
63	3A457	dapsone	Strong inhibitor
64	3A457	deflazacort	Strong inhibitor
65	3A457	dexamethasone	Strong inhibitor
66	3A457	dextromethorphan	Strong inhibitor
67	2C19	diazepam	Moderate inhibitor
68	3A457	diazepam	Strong inhibitor
69	2C9	diclofenac	Weak inhibitor
70	3A457	diltiazem	Strong inhibitor
71	3A457	docetaxel	Strong inhibitor
72	3A457	dolutegravir	Strong inhibitor
73	3A457	domperidone	Strong inhibitor
74	2C19	doxepin	Moderate inhibitor
75	2C9	doxepin	Weak inhibitor
76	3A457	doxepin	Strong inhibitor
77	2B6	efavirenz	Moderate inhibitor
78	3A457	elagolix	Strong inhibitor
79	3A457	elbasvir/grazoprevir	Strong inhibitor
80	3A457	eliglustat	Strong inhibitor
81	3A457	enzalutamide	Strong inhibitor
82	3A457	eplerenone	Strong inhibitor
83	3A457	erythromycin2	Strong inhibitor
84	2C19	escitalopram	Moderate inhibitor
85	3A457	escitalopram	Strong inhibitor
86	2C19	esomeprazole	Moderate inhibitor
87	3A457	esomeprazole	Strong inhibitor
88	3A457	estradiol	Strong inhibitor
89	3A457	felodipine	Strong inhibitor
90	3A457	fentanyl	Strong inhibitor
91	3A457	finasteride	Strong inhibitor
92	2C19	flibanserin	Moderate inhibitor
93	3A457	flibanserin	Strong inhibitor
94	2C9	fluoxetine	Weak inhibitor
95	2C9	fluvastatin	Weak inhibitor
96	3A457	gleevec	Strong inhibitor
97	2C9	glibenclamide	Weak inhibitor
98	2C9	glimepiride	Weak inhibitor
99	2C9	glipizide	Weak inhibitor
100	2C9	glyburide	Weak inhibitor
101	3A457	haloperidol	Strong inhibitor
102	2C19	hexobarbital	Moderate inhibitor
103	3A457	hydrocortisone	Strong inhibitor
104	3A457	ibrutinib	Strong inhibitor
105	2C9	ibuprofen	Weak inhibitor
106	3A457	idelalisib	Strong inhibitor
107	2B6	ifosphamide	Moderate inhibitor
108	2C19	imipramine	Moderate inhibitor
109	3A457	indacaterol	Strong inhibitor
110	3A457	indinavir	Strong inhibitor
111	2C19	indomethacin	Moderate inhibitor
112	2C9	irbesartan	Weak inhibitor
113	3A457	irinotecan	Strong inhibitor
114	3A457	isavuconazonium	Strong inhibitor
115	3A457	ivabradine	Strong inhibitor
116	3A457	ivacaftor	Strong inhibitor
117	2B6	ketamine	Moderate inhibitor
118	3A457	LAAM	Strong inhibitor
119	2C19	labetalol	Moderate inhibitor
120	2C19	lansoprazole	Moderate inhibitor
121	3A457	lansoprazole	Strong inhibitor
122	3A457	lenvatinib	Strong inhibitor
123	3A457	lercanidipine	Strong inhibitor
124	2C9	lesinurad	Weak inhibitor
125	3A457	lidocaine	Strong inhibitor
126	3A457	linagliptin	Strong inhibitor
127	2C9	lornoxicam	Weak inhibitor
128	2C9	losartan	Weak inhibitor
129	3A457	lovastatin	Strong inhibitor
130	3A457	macitentan	Strong inhibitor
131	2C19	mavacamten	Moderate inhibitor
132	3A457	mavacamten	Strong inhibitor
133	2C9	meloxicam	Weak inhibitor
134	2B6	meperidine	Moderate inhibitor
135	3A457	methadone	Strong inhibitor
136	2B6	methadone	Moderate inhibitor
137	3A457	midazolam	Strong inhibitor
138	2C19	moclobemide	Moderate inhibitor
139	3A457	naldemedine	Strong inhibitor
140	3A457	naloxegol	Strong inhibitor
141	2C9	nateglinide	Weak inhibitor
142	3A457	nateglinide	Strong inhibitor
143	2C19	nelfinavir	Moderate inhibitor
144	3A457	nelfinavir	Strong inhibitor
145	3A457	neratinib	Strong inhibitor
146	3A457	netupitant/palonosetron	Strong inhibitor
147	3A457	nevirapine	Strong inhibitor
148	2B6	nevirapine	Moderate inhibitor
149	3A457	nifedipine	Strong inhibitor
150	2C19	nilutamide	Moderate inhibitor
151	3A457	nirmatrelvir	Strong inhibitor
152	3A457	nisoldipine	Strong inhibitor
153	3A457	nitrendipine	Strong inhibitor
154	3A457	olaparib	Strong inhibitor
155	2C9	olodaterol	Weak inhibitor
156	2C19	omeprazole	Moderate inhibitor
157	3A457	omeprazole	Strong inhibitor
158	3A457	ondansetron	Strong inhibitor
159	3A457	osimertinib	Strong inhibitor
160	2C19	ospemifene	Moderate inhibitor
161	2C9	ospemifene	Weak inhibitor
162	3A457	ospemifene	Strong inhibitor
163	3A457	palbociclib	Strong inhibitor
164	3A457	panobinostat	Strong inhibitor
165	2C19	pantoprazole	Moderate inhibitor
166	3A457	pantoprazole	Strong inhibitor
167	3A457	perampanel	Strong inhibitor
168	2C19	phenobarbitone	Moderate inhibitor
169	2C19	phenytoin	Moderate inhibitor
170	2C9	phenytoin	Weak inhibitor
171	3A457	pimavanserin	Strong inhibitor
172	3A457	pimozide	Strong inhibitor
173	2C9	piroxicam	Weak inhibitor
174	2C19	pomalidomide	Moderate inhibitor
175	3A457	pomalidomide	Strong inhibitor
176	3A457	ponatinib	Strong inhibitor
177	2C19	primidone	Moderate inhibitor
178	2C19	progesterone	Moderate inhibitor
179	3A457	progesterone	Strong inhibitor
180	2C19	proguanil	Moderate inhibitor
181	2B6	propafol	Moderate inhibitor
182	2C19	propranolol	Moderate inhibitor
183	3A457	propranolol	Strong inhibitor
184	3A457	quetiapine	Strong inhibitor
185	3A457	quinidine	Strong inhibitor
186	3A457	quinine	Strong inhibitor
187	2C19	r-mephobarbital	Moderate inhibitor
188	2C19	r-warfarin	Moderate inhibitor
189	3A457	regorafenib	Strong inhibitor
190	3A457	ribociclib	Strong inhibitor
191	3A457	rilpivirine	Strong inhibitor
192	3A457	risperidone	Strong inhibitor
193	3A457	ritonavir	Strong inhibitor
194	3A457	rivaroxaban	Strong inhibitor
195	3A457	roflumilast	Strong inhibitor
196	3A457	rolapitant	Strong inhibitor
197	3A457	romidepsin	Strong inhibitor
198	2C9	rosiglitazone	Weak inhibitor
199	3A457	rucaparib	Strong inhibitor
200	3A457	ruxolitinib	Strong inhibitor
201	2C19	s-mephenytoin	Moderate inhibitor
202	2C9	s-warfarin	Weak inhibitor
203	3A457	salmeterol	Strong inhibitor
204	3A457	saquinavir	Strong inhibitor
205	2B6	selegiline	Moderate inhibitor
206	3A457	selexipag	Strong inhibitor
207	3A457	sildenafil	Strong inhibitor
208	3A457	simeprevir	Strong inhibitor
209	3A457	simvastatin	Strong inhibitor
210	3A457	sirolimus	Strong inhibitor
211	3A457	sonidegib	Strong inhibitor
212	3A457	sorafenib	Strong inhibitor
213	2B6	sorafenib	Moderate inhibitor
214	3A457	sunitinib	Strong inhibitor
215	2C9	suprofen	Weak inhibitor
216	2C19	suvorexant	Moderate inhibitor
217	3A457	suvorexant	Strong inhibitor
218	3A457	tacrolimus(fk506)	Strong inhibitor
219	2C9	tamoxifen	Weak inhibitor
220	3A457	tamoxifen	Strong inhibitor
221	3A457	tasimelteon	Strong inhibitor
222	3A457	taxol	Strong inhibitor
223	3A457	telaprevir	Strong inhibitor
224	3A457	telithromycin	Strong inhibitor
225	2C19	teniposide	Moderate inhibitor
226	3A457	terfenadine	Strong inhibitor
227	3A457	testosterone	Strong inhibitor
228	3A457	ticagrelor	Strong inhibitor
229	2C19	tofacitinib	Moderate inhibitor
230	3A457	tofacitinib	Strong inhibitor
231	2C9	tolbutamide	Weak inhibitor
232	3A457	tolvaptan	Strong inhibitor
233	3A457	torisel	Strong inhibitor
234	2C9	torsemide	Weak inhibitor
235	3A457	tramadol	Strong inhibitor
236	2B6	tramadol	Moderate inhibitor
237	3A457	trazodone	Strong inhibitor
238	3A457	valbenazine	Strong inhibitor
239	2C9	valproic acid	Weak inhibitor
240	3A457	vandetanib	Strong inhibitor
241	3A457	velpatasvir	Strong inhibitor
242	2B6	velpatasvir	Moderate inhibitor
243	3A457	vemurafenib	Strong inhibitor
244	3A457	venetoclax	Strong inhibitor
245	2C19	venlafaxine	Moderate inhibitor
246	2C9	venlafaxine	Weak inhibitor
247	3A457	venlafaxine	Strong inhibitor
248	3A457	verapamil	Strong inhibitor
249	2C19	vilazodone	Moderate inhibitor
250	3A457	vilazodone	Strong inhibitor
251	3A457	vincristine	Strong inhibitor
252	3A457	vorapaxar	Strong inhibitor
253	2C19	voriconazole	Moderate inhibitor
254	3A457	voriconazole	Strong inhibitor
255	2C9	zafirlukast	Weak inhibitor
256	3A457	zaleplon	Strong inhibitor
257	3A457	ziprasidone	Strong inhibitor
258	3A457	zolpidem	Strong inhibitor

will decrease voriconazole effect

#

enzyme

inducers

voriconazole will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.