The following drugs will decrease omeprazole effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	2C19	carbamazepine
3	3A457	carbamazepine
4	3A457	clobazam
5	3A457	dabrafenib
6	2C19	efavirenz
7	3A457	efavirenz
8	2C19	enzalutamide
9	3A457	elagolix
10	3A457	enzalutamide
11	2C19	letermovir
12	3A457	eslicarbazepine
13	3A457	glucocorticoids
14	3A457	letermovir
15	3A457	lorlatinib
16	3A457	modafinil
17	3A457	nevirapine
18	3A457	oxcarbazepine
19	2C19	norethindrone
20	3A457	perampanel
21	2C19	prednisone
22	2C19	rifampicin
23	3A457	phenobarbital
24	2C19	ritonavir
25	3A457	phenytoin
26	3A457	pioglitazone
27	3A457	rifabutin
28	3A457	rifampin
29	3A457	St. John's Wort
30	3A457	telotristat
31	3A457	troglitazone
32	3A457	vemurafenib

the follwing drugs will Increase omeprazole effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	2C19	armodafinil	Weak inhibitor
3	3A457	atomoxetine
4	3A457	boceprevir	under review
5	3A457	ceritinib	Strong inhibitor
6	2C19	chloramphenicol	In-Vitro Only
7	3A457	chloramphenicol	In-Vitro Only
8	2C19	cimetidine	Weak inhibitor
9	3A457	cimetidine
10	3A457	ciprofloxacin	under review
11	2C19	citalopram	Weak inhibitor
12	3A457	clarithromycin	Strong inhibitor
13	3A457	crizotinib	Moderate inhibitor
14	3A457	delaviridine	under review
15	3A457	diethyl-dithiocarbamate
16	3A457	diltiazem	Moderate inhibitor
17	3A457	entrectinib
18	3A457	erythromycin	Moderate inhibitor
19	2C19	esomeprazole	Weak inhibitor
20	3A457	esomeprazole
21	2C19	felbamate	Weak inhibitor
22	2C19	fluconazole	Moderate inhibitor
23	3A457	fluconazole	Moderate inhibitor
24	2C19	fluoxetine	Moderate inhibitor
25	2C19	fluvoxamine	Strong inhibitor
26	3A457	fluvoxamine	under review
27	3A457	gestodene	under review
28	3A457	grapefruit juice	Moderate inhibitor
29	3A457	idelalisib	Strong inhibitor
30	3A457	imatinib	under review
31	3A457	indinavir	Strong inhibitor
32	2C19	isoniazid	Weak inhibitor
33	3A457	itraconazole	Strong inhibitor
34	3A457	ivacaftor
35	2C19	ketoconazole	Moderate inhibitor
36	3A457	ketoconazole	Strong inhibitor
37	3A457	lesinurad
38	3A457	letermovir
39	2C19	luliconazole	Weak inhibitor
40	3A457	mibefradil	Strong inhibitor
41	3A457	mifepristone	under review
42	2C19	modafinil	Weak inhibitor
43	3A457	nefazodone	Strong inhibitor
44	3A457	nelfinavir	Strong inhibitor
45	3A457	netupitant/palonosetron	Moderate inhibitor
46	3A457	norfloxacin	under review
47	3A457	norfluoxetine	under review
48	3A457	omeprazole	Weak inhibitor
49	2C19	oral contraceptives	Weak inhibitor
50	2C19	oritavancin	In-Vitro Only
51	2C19	pantoprazole	Weak inhibitor
52	3A457	pantoprazole
53	3A457	perampanel
54	2C19	quercetin	In-Vitro Only
55	3A457	quercetin
56	3A457	regorafenib	under review
57	3A457	ribociclib	Strong inhibitor
58	3A457	ritonavir	Strong inhibitor
59	3A457	rucaparib
60	3A457	saquinavir	Strong inhibitor
61	3A457	simeprevir
62	3A457	starfruit	under review
63	3A457	telaprevir	under review
64	3A457	telithromycin	Strong inhibitor
65	3A457	ticagrelor
66	2C19	ticlopidine	Strong inhibitor
67	2C19	topiramate	under review
68	3A457	tucatinib	Strong inhibitor
69	3A457	verapamil	Moderate inhibitor
70	2C19	voriconazole	Moderate inhibitor
71	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by omeprazole effect

#	enzyme	drug	level
1	3A457	abemaciclib	Weak inhibitor
2	3A457	abiraterone	Weak inhibitor
3	3A457	acalabrutinib	Weak inhibitor
4	3A457	alectinib	Weak inhibitor
5	3A457	alfentanil	Weak inhibitor
6	3A457	alprazolam	Weak inhibitor
7	2C19	amitriptyline	Weak inhibitor
8	3A457	amitriptyline	Weak inhibitor
9	3A457	amlodipine	Weak inhibitor
10	3A457	apixaban	Weak inhibitor
11	3A457	aprepitant	Weak inhibitor
12	3A457	aripiprazole	Weak inhibitor
13	3A457	astemizole	Weak inhibitor
14	2C19	atomoxetine	Weak inhibitor
15	3A457	atorvastatin	Weak inhibitor
16	3A457	avanafil	Weak inhibitor
17	3A457	axitinib	Weak inhibitor
18	3A457	boceprevir	Weak inhibitor
19	3A457	bosutinib	Weak inhibitor
20	3A457	brexpiprazole	Weak inhibitor
21	3A457	brigatinib	Weak inhibitor
22	2C19	brivaracetam	Weak inhibitor
23	3A457	buspirone	Weak inhibitor
24	3A457	cafergot	Weak inhibitor
25	3A457	caffeine	Weak inhibitor
26	3A457	carbamazepine	Weak inhibitor
27	3A457	cariprazine	Weak inhibitor
28	2C19	carisoprodol	Weak inhibitor
29	2C19	celecoxib	Weak inhibitor
30	3A457	ceritinib	Weak inhibitor
31	3A457	cerivastatin	Weak inhibitor
32	2C19	chloramphenicol	Weak inhibitor
33	3A457	chlorpheniramine	Weak inhibitor
34	3A457	cilostazol	Weak inhibitor
35	3A457	cisapride	Weak inhibitor
36	2C19	citalopram	Weak inhibitor
37	3A457	citalopram	Weak inhibitor
38	3A457	clarithromycin	Weak inhibitor
39	2C19	clobazam	Weak inhibitor
40	3A457	clobazam	Weak inhibitor
41	2C19	clomipramine	Weak inhibitor
42	2C19	clopidogrel	Weak inhibitor
43	3A457	clopidogrel	Weak inhibitor
44	3A457	cobimetinib	Weak inhibitor
45	3A457	cocaine	Weak inhibitor
46	3A457	codeine	Weak inhibitor
47	3A457	colchicine	Weak inhibitor
48	3A457	copanlisib	Weak inhibitor
49	3A457	crizotinib	Weak inhibitor
50	2C19	cyclophosphamide	Weak inhibitor
51	3A457	cyclosporine	Weak inhibitor
52	3A457	dabrafenib	Weak inhibitor
53	3A457	daclatasvir	Weak inhibitor
54	3A457	dapsone	Weak inhibitor
55	3A457	deflazacort	Weak inhibitor
56	3A457	dexamethasone	Weak inhibitor
57	3A457	dextromethorphan	Weak inhibitor
58	2C19	diazepam	Weak inhibitor
59	3A457	diazepam	Weak inhibitor
60	3A457	diltiazem	Weak inhibitor
61	3A457	docetaxel	Weak inhibitor
62	3A457	dolutegravir	Weak inhibitor
63	3A457	domperidone	Weak inhibitor
64	2C19	doxepin	Weak inhibitor
65	3A457	doxepin	Weak inhibitor
66	3A457	elagolix	Weak inhibitor
67	3A457	elbasvir/grazoprevir	Weak inhibitor
68	3A457	eliglustat	Weak inhibitor
69	3A457	enzalutamide	Weak inhibitor
70	3A457	eplerenone	Weak inhibitor
71	3A457	erythromycin2	Weak inhibitor
72	2C19	escitalopram	Weak inhibitor
73	3A457	escitalopram	Weak inhibitor
74	2C19	esomeprazole	Weak inhibitor
75	3A457	esomeprazole	Weak inhibitor
76	3A457	estradiol	Weak inhibitor
77	3A457	felodipine	Weak inhibitor
78	3A457	fentanyl	Weak inhibitor
79	3A457	finasteride	Weak inhibitor
80	2C19	flibanserin	Weak inhibitor
81	3A457	flibanserin	Weak inhibitor
82	3A457	gleevec	Weak inhibitor
83	3A457	haloperidol	Weak inhibitor
84	2C19	hexobarbital	Weak inhibitor
85	3A457	hydrocortisone	Weak inhibitor
86	3A457	ibrutinib	Weak inhibitor
87	3A457	idelalisib	Weak inhibitor
88	2C19	imipramine	Weak inhibitor
89	3A457	indacaterol	Weak inhibitor
90	3A457	indinavir	Weak inhibitor
91	2C19	indomethacin	Weak inhibitor
92	3A457	irinotecan	Weak inhibitor
93	3A457	isavuconazonium	Weak inhibitor
94	3A457	ivabradine	Weak inhibitor
95	3A457	ivacaftor	Weak inhibitor
96	3A457	LAAM	Weak inhibitor
97	2C19	labetalol	Weak inhibitor
98	2C19	lansoprazole	Weak inhibitor
99	3A457	lansoprazole	Weak inhibitor
100	3A457	lenvatinib	Weak inhibitor
101	3A457	lercanidipine	Weak inhibitor
102	3A457	lidocaine	Weak inhibitor
103	3A457	linagliptin	Weak inhibitor
104	3A457	lovastatin	Weak inhibitor
105	3A457	macitentan	Weak inhibitor
106	2C19	mavacamten	Weak inhibitor
107	3A457	mavacamten	Weak inhibitor
108	3A457	methadone	Weak inhibitor
109	3A457	midazolam	Weak inhibitor
110	2C19	moclobemide	Weak inhibitor
111	3A457	naldemedine	Weak inhibitor
112	3A457	naloxegol	Weak inhibitor
113	3A457	nateglinide	Weak inhibitor
114	2C19	nelfinavir	Weak inhibitor
115	3A457	nelfinavir	Weak inhibitor
116	3A457	neratinib	Weak inhibitor
117	3A457	netupitant/palonosetron	Weak inhibitor
118	3A457	nevirapine	Weak inhibitor
119	3A457	nifedipine	Weak inhibitor
120	2C19	nilutamide	Weak inhibitor
121	3A457	nirmatrelvir	Weak inhibitor
122	3A457	nisoldipine	Weak inhibitor
123	3A457	nitrendipine	Weak inhibitor
124	3A457	olaparib	Weak inhibitor
125	3A457	omeprazole	Weak inhibitor
126	3A457	ondansetron	Weak inhibitor
127	3A457	osimertinib	Weak inhibitor
128	2C19	ospemifene	Weak inhibitor
129	3A457	ospemifene	Weak inhibitor
130	3A457	palbociclib	Weak inhibitor
131	3A457	panobinostat	Weak inhibitor
132	2C19	pantoprazole	Weak inhibitor
133	3A457	pantoprazole	Weak inhibitor
134	3A457	perampanel	Weak inhibitor
135	2C19	phenobarbitone	Weak inhibitor
136	2C19	phenytoin	Weak inhibitor
137	3A457	pimavanserin	Weak inhibitor
138	3A457	pimozide	Weak inhibitor
139	2C19	pomalidomide	Weak inhibitor
140	3A457	pomalidomide	Weak inhibitor
141	3A457	ponatinib	Weak inhibitor
142	2C19	primidone	Weak inhibitor
143	2C19	progesterone	Weak inhibitor
144	3A457	progesterone	Weak inhibitor
145	2C19	proguanil	Weak inhibitor
146	2C19	propranolol	Weak inhibitor
147	3A457	propranolol	Weak inhibitor
148	3A457	quetiapine	Weak inhibitor
149	3A457	quinidine	Weak inhibitor
150	3A457	quinine	Weak inhibitor
151	2C19	r-mephobarbital	Weak inhibitor
152	2C19	r-warfarin	Weak inhibitor
153	3A457	regorafenib	Weak inhibitor
154	3A457	ribociclib	Weak inhibitor
155	3A457	rilpivirine	Weak inhibitor
156	3A457	risperidone	Weak inhibitor
157	3A457	ritonavir	Weak inhibitor
158	3A457	rivaroxaban	Weak inhibitor
159	3A457	roflumilast	Weak inhibitor
160	3A457	rolapitant	Weak inhibitor
161	3A457	romidepsin	Weak inhibitor
162	3A457	rucaparib	Weak inhibitor
163	3A457	ruxolitinib	Weak inhibitor
164	2C19	s-mephenytoin	Weak inhibitor
165	3A457	salmeterol	Weak inhibitor
166	3A457	saquinavir	Weak inhibitor
167	3A457	selexipag	Weak inhibitor
168	3A457	sildenafil	Weak inhibitor
169	3A457	simeprevir	Weak inhibitor
170	3A457	simvastatin	Weak inhibitor
171	3A457	sirolimus	Weak inhibitor
172	3A457	sonidegib	Weak inhibitor
173	3A457	sorafenib	Weak inhibitor
174	3A457	sunitinib	Weak inhibitor
175	2C19	suvorexant	Weak inhibitor
176	3A457	suvorexant	Weak inhibitor
177	3A457	tacrolimus(fk506)	Weak inhibitor
178	3A457	tamoxifen	Weak inhibitor
179	3A457	tasimelteon	Weak inhibitor
180	3A457	taxol	Weak inhibitor
181	3A457	telaprevir	Weak inhibitor
182	3A457	telithromycin	Weak inhibitor
183	2C19	teniposide	Weak inhibitor
184	3A457	terfenadine	Weak inhibitor
185	3A457	testosterone	Weak inhibitor
186	3A457	ticagrelor	Weak inhibitor
187	2C19	tofacitinib	Weak inhibitor
188	3A457	tofacitinib	Weak inhibitor
189	3A457	tolvaptan	Weak inhibitor
190	3A457	torisel	Weak inhibitor
191	3A457	tramadol	Weak inhibitor
192	3A457	trazodone	Weak inhibitor
193	3A457	valbenazine	Weak inhibitor
194	3A457	vandetanib	Weak inhibitor
195	3A457	velpatasvir	Weak inhibitor
196	3A457	vemurafenib	Weak inhibitor
197	3A457	venetoclax	Weak inhibitor
198	2C19	venlafaxine	Weak inhibitor
199	3A457	venlafaxine	Weak inhibitor
200	3A457	verapamil	Weak inhibitor
201	2C19	vilazodone	Weak inhibitor
202	3A457	vilazodone	Weak inhibitor
203	3A457	vincristine	Weak inhibitor
204	3A457	vorapaxar	Weak inhibitor
205	2C19	voriconazole	Weak inhibitor
206	3A457	voriconazole	Weak inhibitor
207	3A457	zaleplon	Weak inhibitor
208	3A457	ziprasidone	Weak inhibitor
209	3A457	zolpidem	Weak inhibitor

The following drugs will decreased effect by omeprazole effect

#	enzyme	drug
1	1A2	acetaminophen
2	1A2	amitriptyline
3	1A2	apremilast
4	1A2	caffeine
5	1A2	clomipramine
6	1A2	clozapine
7	1A2	cyclobenzaprine
8	1A2	doxepin
9	1A2	duloxetine
10	1A2	estradiol
11	1A2	fluvoxamine
12	1A2	haloperidol
13	1A2	imipramine
14	1A2	mexiletine
15	1A2	nabumetone
16	1A2	naproxen
17	1A2	olanzapine
18	1A2	ondansetron
19	1A2	phenacetin
20	1A2	pirfenidone
21	1A2	pomalidomide
22	1A2	propranolol
23	1A2	riluzole
24	1A2	roflumilast
25	1A2	ropivacaine
26	1A2	rucaparib
27	1A2	tacrine
28	1A2	tasimelteon
29	1A2	theophylline
30	1A2	tizanidine
31	1A2	triamterene
32	1A2	verapamil
33	1A2	warfarin
34	1A2	zileuton
35	1A2	zolmitriptan

will decrease omeprazole effect

#

enzyme

inducers

omeprazole will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.