The following drugs will decrease aprepitant effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	3A457	carbamazepine
3	3A457	clobazam
4	3A457	dabrafenib
5	3A457	efavirenz
6	3A457	elagolix
7	3A457	enzalutamide
8	3A457	eslicarbazepine
9	3A457	glucocorticoids
10	3A457	letermovir
11	3A457	lorlatinib
12	3A457	modafinil
13	3A457	nevirapine
14	3A457	oxcarbazepine
15	3A457	perampanel
16	3A457	phenobarbital
17	3A457	phenytoin
18	3A457	pioglitazone
19	3A457	rifabutin
20	3A457	rifampin
21	3A457	St. John's Wort
22	3A457	telotristat
23	3A457	troglitazone
24	3A457	vemurafenib

the follwing drugs will Increase aprepitant effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	3A457	atomoxetine
3	3A457	boceprevir	under review
4	3A457	ceritinib	Strong inhibitor
5	3A457	chloramphenicol	In-Vitro Only
6	3A457	cimetidine
7	3A457	ciprofloxacin	under review
8	3A457	clarithromycin	Strong inhibitor
9	3A457	crizotinib	Moderate inhibitor
10	3A457	delaviridine	under review
11	3A457	diethyl-dithiocarbamate
12	3A457	diltiazem	Moderate inhibitor
13	3A457	entrectinib
14	3A457	erythromycin	Moderate inhibitor
15	3A457	esomeprazole
16	3A457	fluconazole	Moderate inhibitor
17	3A457	fluvoxamine	under review
18	3A457	gestodene	under review
19	3A457	grapefruit juice	Moderate inhibitor
20	3A457	idelalisib	Strong inhibitor
21	3A457	imatinib	under review
22	3A457	indinavir	Strong inhibitor
23	3A457	itraconazole	Strong inhibitor
24	3A457	ivacaftor
25	3A457	ketoconazole	Strong inhibitor
26	3A457	lesinurad
27	3A457	letermovir
28	3A457	mibefradil	Strong inhibitor
29	3A457	mifepristone	under review
30	3A457	nefazodone	Strong inhibitor
31	3A457	nelfinavir	Strong inhibitor
32	3A457	netupitant/palonosetron	Moderate inhibitor
33	3A457	norfloxacin	under review
34	3A457	norfluoxetine	under review
35	3A457	omeprazole	Weak inhibitor
36	3A457	pantoprazole
37	3A457	perampanel
38	3A457	quercetin
39	3A457	regorafenib	under review
40	3A457	ribociclib	Strong inhibitor
41	3A457	ritonavir	Strong inhibitor
42	3A457	rucaparib
43	3A457	saquinavir	Strong inhibitor
44	3A457	simeprevir
45	3A457	starfruit	under review
46	3A457	telaprevir	under review
47	3A457	telithromycin	Strong inhibitor
48	3A457	ticagrelor
49	3A457	tucatinib	Strong inhibitor
50	3A457	verapamil	Moderate inhibitor
51	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by aprepitant effect

#	enzyme	drug	level
1	3A457	abemaciclib	Moderate inhibitor
2	3A457	abiraterone	Moderate inhibitor
3	3A457	acalabrutinib	Moderate inhibitor
4	3A457	alectinib	Moderate inhibitor
5	3A457	alfentanil	Moderate inhibitor
6	3A457	alprazolam	Moderate inhibitor
7	3A457	amitriptyline	Moderate inhibitor
8	3A457	amlodipine	Moderate inhibitor
9	3A457	apixaban	Moderate inhibitor
10	3A457	aprepitant	Moderate inhibitor
11	3A457	aripiprazole	Moderate inhibitor
12	3A457	astemizole	Moderate inhibitor
13	3A457	atorvastatin	Moderate inhibitor
14	3A457	avanafil	Moderate inhibitor
15	3A457	axitinib	Moderate inhibitor
16	3A457	boceprevir	Moderate inhibitor
17	3A457	bosutinib	Moderate inhibitor
18	3A457	brexpiprazole	Moderate inhibitor
19	3A457	brigatinib	Moderate inhibitor
20	3A457	buspirone	Moderate inhibitor
21	3A457	cafergot	Moderate inhibitor
22	3A457	caffeine	Moderate inhibitor
23	3A457	carbamazepine	Moderate inhibitor
24	3A457	cariprazine	Moderate inhibitor
25	3A457	ceritinib	Moderate inhibitor
26	3A457	cerivastatin	Moderate inhibitor
27	3A457	chlorpheniramine	Moderate inhibitor
28	3A457	cilostazol	Moderate inhibitor
29	3A457	cisapride	Moderate inhibitor
30	3A457	citalopram	Moderate inhibitor
31	3A457	clarithromycin	Moderate inhibitor
32	3A457	clobazam	Moderate inhibitor
33	3A457	clopidogrel	Moderate inhibitor
34	3A457	cobimetinib	Moderate inhibitor
35	3A457	cocaine	Moderate inhibitor
36	3A457	codeine	Moderate inhibitor
37	3A457	colchicine	Moderate inhibitor
38	3A457	copanlisib	Moderate inhibitor
39	3A457	crizotinib	Moderate inhibitor
40	3A457	cyclosporine	Moderate inhibitor
41	3A457	dabrafenib	Moderate inhibitor
42	3A457	daclatasvir	Moderate inhibitor
43	3A457	dapsone	Moderate inhibitor
44	3A457	deflazacort	Moderate inhibitor
45	3A457	dexamethasone	Moderate inhibitor
46	3A457	dextromethorphan	Moderate inhibitor
47	3A457	diazepam	Moderate inhibitor
48	3A457	diltiazem	Moderate inhibitor
49	3A457	docetaxel	Moderate inhibitor
50	3A457	dolutegravir	Moderate inhibitor
51	3A457	domperidone	Moderate inhibitor
52	3A457	doxepin	Moderate inhibitor
53	3A457	elagolix	Moderate inhibitor
54	3A457	elbasvir/grazoprevir	Moderate inhibitor
55	3A457	eliglustat	Moderate inhibitor
56	3A457	enzalutamide	Moderate inhibitor
57	3A457	eplerenone	Moderate inhibitor
58	3A457	erythromycin2	Moderate inhibitor
59	3A457	escitalopram	Moderate inhibitor
60	3A457	esomeprazole	Moderate inhibitor
61	3A457	estradiol	Moderate inhibitor
62	3A457	felodipine	Moderate inhibitor
63	3A457	fentanyl	Moderate inhibitor
64	3A457	finasteride	Moderate inhibitor
65	3A457	flibanserin	Moderate inhibitor
66	3A457	gleevec	Moderate inhibitor
67	3A457	haloperidol	Moderate inhibitor
68	3A457	hydrocortisone	Moderate inhibitor
69	3A457	ibrutinib	Moderate inhibitor
70	3A457	idelalisib	Moderate inhibitor
71	3A457	indacaterol	Moderate inhibitor
72	3A457	indinavir	Moderate inhibitor
73	3A457	irinotecan	Moderate inhibitor
74	3A457	isavuconazonium	Moderate inhibitor
75	3A457	ivabradine	Moderate inhibitor
76	3A457	ivacaftor	Moderate inhibitor
77	3A457	LAAM	Moderate inhibitor
78	3A457	lansoprazole	Moderate inhibitor
79	3A457	lenvatinib	Moderate inhibitor
80	3A457	lercanidipine	Moderate inhibitor
81	3A457	lidocaine	Moderate inhibitor
82	3A457	linagliptin	Moderate inhibitor
83	3A457	lovastatin	Moderate inhibitor
84	3A457	macitentan	Moderate inhibitor
85	3A457	mavacamten	Moderate inhibitor
86	3A457	methadone	Moderate inhibitor
87	3A457	midazolam	Moderate inhibitor
88	3A457	naldemedine	Moderate inhibitor
89	3A457	naloxegol	Moderate inhibitor
90	3A457	nateglinide	Moderate inhibitor
91	3A457	nelfinavir	Moderate inhibitor
92	3A457	neratinib	Moderate inhibitor
93	3A457	netupitant/palonosetron	Moderate inhibitor
94	3A457	nevirapine	Moderate inhibitor
95	3A457	nifedipine	Moderate inhibitor
96	3A457	nirmatrelvir	Moderate inhibitor
97	3A457	nisoldipine	Moderate inhibitor
98	3A457	nitrendipine	Moderate inhibitor
99	3A457	olaparib	Moderate inhibitor
100	3A457	omeprazole	Moderate inhibitor
101	3A457	ondansetron	Moderate inhibitor
102	3A457	osimertinib	Moderate inhibitor
103	3A457	ospemifene	Moderate inhibitor
104	3A457	palbociclib	Moderate inhibitor
105	3A457	panobinostat	Moderate inhibitor
106	3A457	pantoprazole	Moderate inhibitor
107	3A457	perampanel	Moderate inhibitor
108	3A457	pimavanserin	Moderate inhibitor
109	3A457	pimozide	Moderate inhibitor
110	3A457	pomalidomide	Moderate inhibitor
111	3A457	ponatinib	Moderate inhibitor
112	3A457	progesterone	Moderate inhibitor
113	3A457	propranolol	Moderate inhibitor
114	3A457	quetiapine	Moderate inhibitor
115	3A457	quinidine	Moderate inhibitor
116	3A457	quinine	Moderate inhibitor
117	3A457	regorafenib	Moderate inhibitor
118	3A457	ribociclib	Moderate inhibitor
119	3A457	rilpivirine	Moderate inhibitor
120	3A457	risperidone	Moderate inhibitor
121	3A457	ritonavir	Moderate inhibitor
122	3A457	rivaroxaban	Moderate inhibitor
123	3A457	roflumilast	Moderate inhibitor
124	3A457	rolapitant	Moderate inhibitor
125	3A457	romidepsin	Moderate inhibitor
126	3A457	rucaparib	Moderate inhibitor
127	3A457	ruxolitinib	Moderate inhibitor
128	3A457	salmeterol	Moderate inhibitor
129	3A457	saquinavir	Moderate inhibitor
130	3A457	selexipag	Moderate inhibitor
131	3A457	sildenafil	Moderate inhibitor
132	3A457	simeprevir	Moderate inhibitor
133	3A457	simvastatin	Moderate inhibitor
134	3A457	sirolimus	Moderate inhibitor
135	3A457	sonidegib	Moderate inhibitor
136	3A457	sorafenib	Moderate inhibitor
137	3A457	sunitinib	Moderate inhibitor
138	3A457	suvorexant	Moderate inhibitor
139	3A457	tacrolimus(fk506)	Moderate inhibitor
140	3A457	tamoxifen	Moderate inhibitor
141	3A457	tasimelteon	Moderate inhibitor
142	3A457	taxol	Moderate inhibitor
143	3A457	telaprevir	Moderate inhibitor
144	3A457	telithromycin	Moderate inhibitor
145	3A457	terfenadine	Moderate inhibitor
146	3A457	testosterone	Moderate inhibitor
147	3A457	ticagrelor	Moderate inhibitor
148	3A457	tofacitinib	Moderate inhibitor
149	3A457	tolvaptan	Moderate inhibitor
150	3A457	torisel	Moderate inhibitor
151	3A457	tramadol	Moderate inhibitor
152	3A457	trazodone	Moderate inhibitor
153	3A457	valbenazine	Moderate inhibitor
154	3A457	vandetanib	Moderate inhibitor
155	3A457	velpatasvir	Moderate inhibitor
156	3A457	vemurafenib	Moderate inhibitor
157	3A457	venetoclax	Moderate inhibitor
158	3A457	venlafaxine	Moderate inhibitor
159	3A457	verapamil	Moderate inhibitor
160	3A457	vilazodone	Moderate inhibitor
161	3A457	vincristine	Moderate inhibitor
162	3A457	vorapaxar	Moderate inhibitor
163	3A457	voriconazole	Moderate inhibitor
164	3A457	zaleplon	Moderate inhibitor
165	3A457	ziprasidone	Moderate inhibitor
166	3A457	zolpidem	Moderate inhibitor

will decrease aprepitant effect

#

enzyme

inducers

aprepitant will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.