letermovir
The following drugs will decrease letermovir effect
the follwing drugs will
Increase letermovir effect
The follwing drugs will Increase effect by letermovir effect
| # | enzyme | drug | level |
| 1 | 3A457 | abemaciclib | |
| 2 | 3A457 | abiraterone | |
| 3 | 3A457 | acalabrutinib | |
| 4 | 3A457 | alectinib | |
| 5 | 3A457 | alfentanil | |
| 6 | 3A457 | alprazolam | |
| 7 | 3A457 | amitriptyline | |
| 8 | 3A457 | amlodipine | |
| 9 | 2C8 | amodiaquine | In-Vitro Only |
| 10 | 3A457 | apixaban | |
| 11 | 3A457 | aprepitant | |
| 12 | 3A457 | aripiprazole | |
| 13 | 3A457 | astemizole | |
| 14 | 3A457 | atorvastatin | |
| 15 | 3A457 | avanafil | |
| 16 | 3A457 | axitinib | |
| 17 | 3A457 | boceprevir | |
| 18 | 3A457 | bosutinib | |
| 19 | 3A457 | brexpiprazole | |
| 20 | 3A457 | brigatinib | |
| 21 | 3A457 | buspirone | |
| 22 | 3A457 | cafergot | |
| 23 | 3A457 | caffeine | |
| 24 | 3A457 | carbamazepine | |
| 25 | 3A457 | cariprazine | |
| 26 | 3A457 | ceritinib | |
| 27 | 2C8 | cerivastatin | In-Vitro Only |
| 28 | 3A457 | cerivastatin | |
| 29 | 3A457 | chlorpheniramine | |
| 30 | 3A457 | cilostazol | |
| 31 | 3A457 | cisapride | |
| 32 | 3A457 | citalopram | |
| 33 | 3A457 | clarithromycin | |
| 34 | 3A457 | clobazam | |
| 35 | 3A457 | clopidogrel | |
| 36 | 3A457 | cobimetinib | |
| 37 | 3A457 | cocaine | |
| 38 | 3A457 | codeine | |
| 39 | 3A457 | colchicine | |
| 40 | 3A457 | copanlisib | |
| 41 | 3A457 | crizotinib | |
| 42 | 3A457 | cyclosporine | |
| 43 | 2C8 | dabrafenib | In-Vitro Only |
| 44 | 3A457 | dabrafenib | |
| 45 | 3A457 | daclatasvir | |
| 46 | 3A457 | dapsone | |
| 47 | 3A457 | deflazacort | |
| 48 | 3A457 | dexamethasone | |
| 49 | 3A457 | dextromethorphan | |
| 50 | 3A457 | diazepam | |
| 51 | 3A457 | diltiazem | |
| 52 | 3A457 | docetaxel | |
| 53 | 3A457 | dolutegravir | |
| 54 | 3A457 | domperidone | |
| 55 | 3A457 | doxepin | |
| 56 | 3A457 | elagolix | |
| 57 | 3A457 | elbasvir/grazoprevir | |
| 58 | 3A457 | eliglustat | |
| 59 | 2C8 | enzalutamide | In-Vitro Only |
| 60 | 3A457 | enzalutamide | |
| 61 | 3A457 | eplerenone | |
| 62 | 3A457 | erythromycin2 | |
| 63 | 3A457 | escitalopram | |
| 64 | 3A457 | esomeprazole | |
| 65 | 3A457 | estradiol | |
| 66 | 3A457 | felodipine | |
| 67 | 3A457 | fentanyl | |
| 68 | 3A457 | finasteride | |
| 69 | 3A457 | flibanserin | |
| 70 | 3A457 | gleevec | |
| 71 | 3A457 | haloperidol | |
| 72 | 3A457 | hydrocortisone | |
| 73 | 3A457 | ibrutinib | |
| 74 | 3A457 | idelalisib | |
| 75 | 3A457 | indacaterol | |
| 76 | 3A457 | indinavir | |
| 77 | 3A457 | irinotecan | |
| 78 | 3A457 | isavuconazonium | |
| 79 | 3A457 | ivabradine | |
| 80 | 3A457 | ivacaftor | |
| 81 | 3A457 | LAAM | |
| 82 | 3A457 | lansoprazole | |
| 83 | 3A457 | lenvatinib | |
| 84 | 3A457 | lercanidipine | |
| 85 | 3A457 | lidocaine | |
| 86 | 3A457 | linagliptin | |
| 87 | 3A457 | lovastatin | |
| 88 | 3A457 | macitentan | |
| 89 | 3A457 | mavacamten | |
| 90 | 3A457 | methadone | |
| 91 | 3A457 | midazolam | |
| 92 | 3A457 | naldemedine | |
| 93 | 3A457 | naloxegol | |
| 94 | 3A457 | nateglinide | |
| 95 | 3A457 | nelfinavir | |
| 96 | 3A457 | neratinib | |
| 97 | 3A457 | netupitant/palonosetron | |
| 98 | 3A457 | nevirapine | |
| 99 | 3A457 | nifedipine | |
| 100 | 3A457 | nirmatrelvir | |
| 101 | 3A457 | nisoldipine | |
| 102 | 3A457 | nitrendipine | |
| 103 | 3A457 | olaparib | |
| 104 | 2C8 | olodaterol | In-Vitro Only |
| 105 | 3A457 | omeprazole | |
| 106 | 3A457 | ondansetron | |
| 107 | 3A457 | osimertinib | |
| 108 | 3A457 | ospemifene | |
| 109 | 2C8 | paclitaxel | In-Vitro Only |
| 110 | 3A457 | palbociclib | |
| 111 | 3A457 | panobinostat | |
| 112 | 3A457 | pantoprazole | |
| 113 | 3A457 | perampanel | |
| 114 | 3A457 | pimavanserin | |
| 115 | 3A457 | pimozide | |
| 116 | 3A457 | pomalidomide | |
| 117 | 2C8 | ponatinib | In-Vitro Only |
| 118 | 3A457 | ponatinib | |
| 119 | 3A457 | progesterone | |
| 120 | 3A457 | propranolol | |
| 121 | 3A457 | quetiapine | |
| 122 | 3A457 | quinidine | |
| 123 | 3A457 | quinine | |
| 124 | 3A457 | regorafenib | |
| 125 | 2C8 | repaglinide | In-Vitro Only |
| 126 | 3A457 | ribociclib | |
| 127 | 3A457 | rilpivirine | |
| 128 | 3A457 | risperidone | |
| 129 | 3A457 | ritonavir | |
| 130 | 3A457 | rivaroxaban | |
| 131 | 3A457 | roflumilast | |
| 132 | 3A457 | rolapitant | |
| 133 | 3A457 | romidepsin | |
| 134 | 3A457 | rucaparib | |
| 135 | 3A457 | ruxolitinib | |
| 136 | 3A457 | salmeterol | |
| 137 | 3A457 | saquinavir | |
| 138 | 2C8 | selexipag | In-Vitro Only |
| 139 | 3A457 | selexipag | |
| 140 | 3A457 | sildenafil | |
| 141 | 3A457 | simeprevir | |
| 142 | 3A457 | simvastatin | |
| 143 | 3A457 | sirolimus | |
| 144 | 3A457 | sonidegib | |
| 145 | 2C8 | sorafenib | In-Vitro Only |
| 146 | 3A457 | sorafenib | |
| 147 | 3A457 | sunitinib | |
| 148 | 3A457 | suvorexant | |
| 149 | 3A457 | tacrolimus(fk506) | |
| 150 | 3A457 | tamoxifen | |
| 151 | 3A457 | tasimelteon | |
| 152 | 3A457 | taxol | |
| 153 | 3A457 | telaprevir | |
| 154 | 3A457 | telithromycin | |
| 155 | 3A457 | terfenadine | |
| 156 | 3A457 | testosterone | |
| 157 | 3A457 | ticagrelor | |
| 158 | 3A457 | tofacitinib | |
| 159 | 3A457 | tolvaptan | |
| 160 | 3A457 | torisel | |
| 161 | 2C8 | torsemide | In-Vitro Only |
| 162 | 3A457 | tramadol | |
| 163 | 3A457 | trazodone | |
| 164 | 2C8 | tucatinib | In-Vitro Only |
| 165 | 3A457 | valbenazine | |
| 166 | 3A457 | vandetanib | |
| 167 | 3A457 | velpatasvir | |
| 168 | 3A457 | vemurafenib | |
| 169 | 3A457 | venetoclax | |
| 170 | 3A457 | venlafaxine | |
| 171 | 3A457 | verapamil | |
| 172 | 3A457 | vilazodone | |
| 173 | 3A457 | vincristine | |
| 174 | 3A457 | vorapaxar | |
| 175 | 3A457 | voriconazole | |
| 176 | 3A457 | zaleplon | |
| 177 | 3A457 | ziprasidone | |
| 178 | 3A457 | zolpidem | |
The following drugs will decreased effect by letermovir effect
| # | enzyme | drug |
| 1 | 3A457 | abemaciclib |
| 2 | 3A457 | abiraterone |
| 3 | 3A457 | acalabrutinib |
| 4 | 3A457 | alectinib |
| 5 | 3A457 | alfentanil |
| 6 | 3A457 | alprazolam |
| 7 | 2C19 | amitriptyline |
| 8 | 2C9 | amitriptyline |
| 9 | 3A457 | amitriptyline |
| 10 | 3A457 | amlodipine |
| 11 | 3A457 | apixaban |
| 12 | 3A457 | aprepitant |
| 13 | 3A457 | aripiprazole |
| 14 | 2B6 | artemisinin |
| 15 | 3A457 | astemizole |
| 16 | 2C19 | atomoxetine |
| 17 | 3A457 | atorvastatin |
| 18 | 3A457 | avanafil |
| 19 | 3A457 | axitinib |
| 20 | 2C9 | azilsartan |
| 21 | 3A457 | boceprevir |
| 22 | 3A457 | bosutinib |
| 23 | 3A457 | brexpiprazole |
| 24 | 3A457 | brigatinib |
| 25 | 2C19 | brivaracetam |
| 26 | 2B6 | bupropion |
| 27 | 3A457 | buspirone |
| 28 | 3A457 | cafergot |
| 29 | 3A457 | caffeine |
| 30 | 2C9 | capecitabine |
| 31 | 3A457 | carbamazepine |
| 32 | 3A457 | cariprazine |
| 33 | 2C19 | carisoprodol |
| 34 | 2C19 | celecoxib |
| 35 | 2C9 | celecoxib |
| 36 | 3A457 | ceritinib |
| 37 | 3A457 | cerivastatin |
| 38 | 2C19 | chloramphenicol |
| 39 | 3A457 | chlorpheniramine |
| 40 | 3A457 | cilostazol |
| 41 | 3A457 | cisapride |
| 42 | 3A457 | citalopram |
| 43 | 3A457 | clarithromycin |
| 44 | 2B6 | clobazam |
| 45 | 2C19 | clobazam |
| 46 | 3A457 | clobazam |
| 47 | 2C19 | clomipramine |
| 48 | 2C19 | clopidogrel |
| 49 | 2C9 | clopidogrel |
| 50 | 3A457 | clopidogrel |
| 51 | 3A457 | cobimetinib |
| 52 | 3A457 | cocaine |
| 53 | 3A457 | codeine |
| 54 | 3A457 | colchicine |
| 55 | 3A457 | copanlisib |
| 56 | 3A457 | crizotinib |
| 57 | 2B6 | cyclophosphamide |
| 58 | 2C19 | cyclophosphamide |
| 59 | 3A457 | cyclosporine |
| 60 | 3A457 | dabrafenib |
| 61 | 3A457 | daclatasvir |
| 62 | 3A457 | dapsone |
| 63 | 3A457 | deflazacort |
| 64 | 3A457 | dexamethasone |
| 65 | 3A457 | dextromethorphan |
| 66 | 2C19 | diazepam |
| 67 | 3A457 | diazepam |
| 68 | 2C9 | diclofenac |
| 69 | 3A457 | diltiazem |
| 70 | 3A457 | docetaxel |
| 71 | 3A457 | dolutegravir |
| 72 | 3A457 | domperidone |
| 73 | 2C19 | doxepin |
| 74 | 2C9 | doxepin |
| 75 | 3A457 | doxepin |
| 76 | 2B6 | efavirenz |
| 77 | 3A457 | elagolix |
| 78 | 3A457 | elbasvir/grazoprevir |
| 79 | 3A457 | eliglustat |
| 80 | 3A457 | enzalutamide |
| 81 | 3A457 | eplerenone |
| 82 | 3A457 | erythromycin2 |
| 83 | 2C19 | escitalopram |
| 84 | 3A457 | escitalopram |
| 85 | 2C19 | esomeprazole |
| 86 | 3A457 | esomeprazole |
| 87 | 3A457 | estradiol |
| 88 | 3A457 | felodipine |
| 89 | 3A457 | fentanyl |
| 90 | 3A457 | finasteride |
| 91 | 2C19 | flibanserin |
| 92 | 3A457 | flibanserin |
| 93 | 2C9 | fluoxetine |
| 94 | 2C9 | fluvastatin |
| 95 | 3A457 | gleevec |
| 96 | 2C9 | glibenclamide |
| 97 | 2C9 | glimepiride |
| 98 | 2C9 | glipizide |
| 99 | 2C9 | glyburide |
| 100 | 3A457 | haloperidol |
| 101 | 2C19 | hexobarbital |
| 102 | 3A457 | hydrocortisone |
| 103 | 3A457 | ibrutinib |
| 104 | 2C9 | ibuprofen |
| 105 | 3A457 | idelalisib |
| 106 | 2B6 | ifosphamide |
| 107 | 2C19 | imipramine |
| 108 | 3A457 | indacaterol |
| 109 | 3A457 | indinavir |
| 110 | 2C19 | indomethacin |
| 111 | 2C9 | irbesartan |
| 112 | 3A457 | irinotecan |
| 113 | 3A457 | isavuconazonium |
| 114 | 3A457 | ivabradine |
| 115 | 3A457 | ivacaftor |
| 116 | 2B6 | ketamine |
| 117 | 3A457 | LAAM |
| 118 | 2C19 | labetalol |
| 119 | 2C19 | lansoprazole |
| 120 | 3A457 | lansoprazole |
| 121 | 3A457 | lenvatinib |
| 122 | 3A457 | lercanidipine |
| 123 | 2C9 | lesinurad |
| 124 | 3A457 | lidocaine |
| 125 | 3A457 | linagliptin |
| 126 | 2C9 | lornoxicam |
| 127 | 2C9 | losartan |
| 128 | 3A457 | lovastatin |
| 129 | 3A457 | macitentan |
| 130 | 2C19 | mavacamten |
| 131 | 3A457 | mavacamten |
| 132 | 2C9 | meloxicam |
| 133 | 2B6 | meperidine |
| 134 | 2B6 | methadone |
| 135 | 3A457 | methadone |
| 136 | 3A457 | midazolam |
| 137 | 2C19 | moclobemide |
| 138 | 3A457 | naldemedine |
| 139 | 3A457 | naloxegol |
| 140 | 2C9 | nateglinide |
| 141 | 3A457 | nateglinide |
| 142 | 2C19 | nelfinavir |
| 143 | 3A457 | nelfinavir |
| 144 | 3A457 | neratinib |
| 145 | 3A457 | netupitant/palonosetron |
| 146 | 2B6 | nevirapine |
| 147 | 3A457 | nevirapine |
| 148 | 3A457 | nifedipine |
| 149 | 2C19 | nilutamide |
| 150 | 3A457 | nirmatrelvir |
| 151 | 3A457 | nisoldipine |
| 152 | 3A457 | nitrendipine |
| 153 | 3A457 | olaparib |
| 154 | 2C9 | olodaterol |
| 155 | 2C19 | omeprazole |
| 156 | 3A457 | omeprazole |
| 157 | 3A457 | ondansetron |
| 158 | 3A457 | osimertinib |
| 159 | 2C19 | ospemifene |
| 160 | 2C9 | ospemifene |
| 161 | 3A457 | ospemifene |
| 162 | 3A457 | palbociclib |
| 163 | 3A457 | panobinostat |
| 164 | 2C19 | pantoprazole |
| 165 | 3A457 | pantoprazole |
| 166 | 3A457 | perampanel |
| 167 | 2C19 | phenobarbitone |
| 168 | 2C19 | phenytoin |
| 169 | 2C9 | phenytoin |
| 170 | 3A457 | pimavanserin |
| 171 | 3A457 | pimozide |
| 172 | 2C9 | piroxicam |
| 173 | 2C19 | pomalidomide |
| 174 | 3A457 | pomalidomide |
| 175 | 3A457 | ponatinib |
| 176 | 2C19 | primidone |
| 177 | 2C19 | progesterone |
| 178 | 3A457 | progesterone |
| 179 | 2C19 | proguanil |
| 180 | 2B6 | propafol |
| 181 | 2C19 | propranolol |
| 182 | 3A457 | propranolol |
| 183 | 3A457 | quetiapine |
| 184 | 3A457 | quinidine |
| 185 | 3A457 | quinine |
| 186 | 2C19 | r-mephobarbital |
| 187 | 2C19 | r-warfarin |
| 188 | 3A457 | regorafenib |
| 189 | 3A457 | ribociclib |
| 190 | 3A457 | rilpivirine |
| 191 | 3A457 | risperidone |
| 192 | 3A457 | ritonavir |
| 193 | 3A457 | rivaroxaban |
| 194 | 3A457 | roflumilast |
| 195 | 3A457 | rolapitant |
| 196 | 3A457 | romidepsin |
| 197 | 2C9 | rosiglitazone |
| 198 | 3A457 | rucaparib |
| 199 | 3A457 | ruxolitinib |
| 200 | 2C19 | s-mephenytoin |
| 201 | 2C9 | s-warfarin |
| 202 | 3A457 | salmeterol |
| 203 | 3A457 | saquinavir |
| 204 | 2B6 | selegiline |
| 205 | 3A457 | selexipag |
| 206 | 3A457 | sildenafil |
| 207 | 3A457 | simeprevir |
| 208 | 3A457 | simvastatin |
| 209 | 3A457 | sirolimus |
| 210 | 3A457 | sonidegib |
| 211 | 2B6 | sorafenib |
| 212 | 3A457 | sorafenib |
| 213 | 3A457 | sunitinib |
| 214 | 2C9 | suprofen |
| 215 | 2C19 | suvorexant |
| 216 | 3A457 | suvorexant |
| 217 | 3A457 | tacrolimus(fk506) |
| 218 | 2C9 | tamoxifen |
| 219 | 3A457 | tamoxifen |
| 220 | 3A457 | tasimelteon |
| 221 | 3A457 | taxol |
| 222 | 3A457 | telaprevir |
| 223 | 3A457 | telithromycin |
| 224 | 2C19 | teniposide |
| 225 | 3A457 | terfenadine |
| 226 | 3A457 | testosterone |
| 227 | 3A457 | ticagrelor |
| 228 | 2C19 | tofacitinib |
| 229 | 3A457 | tofacitinib |
| 230 | 2C9 | tolbutamide |
| 231 | 3A457 | tolvaptan |
| 232 | 3A457 | torisel |
| 233 | 2C9 | torsemide |
| 234 | 2B6 | tramadol |
| 235 | 3A457 | tramadol |
| 236 | 3A457 | trazodone |
| 237 | 3A457 | valbenazine |
| 238 | 2C9 | valproic acid |
| 239 | 3A457 | vandetanib |
| 240 | 2B6 | velpatasvir |
| 241 | 3A457 | velpatasvir |
| 242 | 3A457 | vemurafenib |
| 243 | 3A457 | venetoclax |
| 244 | 2C19 | venlafaxine |
| 245 | 2C9 | venlafaxine |
| 246 | 3A457 | venlafaxine |
| 247 | 3A457 | verapamil |
| 248 | 2C19 | vilazodone |
| 249 | 3A457 | vilazodone |
| 250 | 3A457 | vincristine |
| 251 | 3A457 | vorapaxar |
| 252 | 2C19 | voriconazole |
| 253 | 2C9 | voriconazole |
| 254 | 3A457 | voriconazole |
| 255 | 2C9 | zafirlukast |
| 256 | 3A457 | zaleplon |
| 257 | 3A457 | ziprasidone |
| 258 | 3A457 | zolpidem |
will
decrease letermovir effect
letermovir will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.