fluoxetine
The following drugs will decrease fluoxetine effect
# | enzyme | inducers |
0 | 2C9 | carbamazepine |
1 | 2C9 | dabrafenib |
2 | 2C9 | enzalutamide |
3 | 2C9 | letermovir |
4 | 2C9 | nevirapine |
5 | 2C9 | phenobarbital |
6 | 2C9 | rifampin |
7 | 2C9 | secobarbital |
the follwing drugs will
Increase fluoxetine effect
# | enzyme | Inhibitors | level |
0 | 2D6 | abiraterone | Moderate inhibitor |
1 | 2C9 | amiodarone | Moderate inhibitor |
2 | 2D6 | amiodarone | Weak inhibitor |
3 | 2D6 | bupropion | Strong inhibitor |
4 | 2C9 | capecitabine | Weak inhibitor |
5 | 2D6 | celecoxib | Weak inhibitor |
6 | 2C9 | ceritinib | Weak inhibitor |
7 | 2D6 | chlorpromazine | In-Vitro Only |
8 | 2D6 | cimetidine | Weak inhibitor |
9 | 2D6 | cinacalcet | Moderate inhibitor |
10 | 2D6 | citalopram | Weak inhibitor |
11 | 2D6 | clemastine | In-Vitro Only |
12 | 2D6 | clobazam | |
13 | 2D6 | clomipramine | |
14 | 2D6 | cocaine | In-Vitro Only |
15 | 2D6 | diphenhydramine | |
16 | 2D6 | doxepin | Moderate inhibitor |
17 | 2D6 | duloxetine | Moderate inhibitor |
18 | 2C9 | efavirenz | Weak inhibitor |
19 | 2D6 | escitalopram | |
20 | 2C9 | fenofibrate | In-Vitro Only |
21 | 2C9 | fluconazole | Moderate inhibitor |
22 | 2D6 | fluoxetine | Strong inhibitor |
23 | 2C9 | fluvastatin | In-Vitro Only |
24 | 2C9 | fluvoxamine | In-Vitro Only |
25 | 2D6 | halofantrine | Moderate inhibitor |
26 | 2D6 | haloperidol | In-Vitro Only |
27 | 2D6 | hydroxyzine | In-Vitro Only |
28 | 2C9 | isoniazid | Weak inhibitor |
29 | 2D6 | levomepromazine | |
30 | 2D6 | lorcaserin | Moderate inhibitor |
31 | 2D6 | methadone | under review |
32 | 2D6 | metoclopramide | In-Vitro Only |
33 | 2C9 | metronidazole | Moderate inhibitor |
34 | 2D6 | midodrine | |
35 | 2D6 | moclobemide | Moderate inhibitor |
36 | 2D6 | panobinostat | under review |
37 | 2D6 | paroxetine | Strong inhibitor |
38 | 2D6 | perphenazine | In-Vitro Only |
39 | 2C9 | phenylbutazone | Moderate inhibitor |
40 | 2D6 | promethazine | under review |
41 | 2C9 | quercetin | Weak inhibitor |
42 | 2D6 | quinidine | Strong inhibitor |
43 | 2D6 | ritonavir | |
44 | 2D6 | rolapitant | Moderate inhibitor |
45 | 2D6 | sertraline | |
46 | 2C9 | sulfamethoxazole | Weak inhibitor |
47 | 2C9 | sulfaphenazole | Strong inhibitor |
48 | 2D6 | terbinafine (oral) | Moderate inhibitor |
49 | 2D6 | ticlopidine | In-Vitro Only |
50 | 2D6 | tripelennamine | In-Vitro Only |
51 | 2D6 | vemurafenib | |
52 | 2C9 | voriconazole | Weak inhibitor |
53 | 2C9 | zafirlukast | Weak inhibitor |
The follwing drugs will Increase effect by fluoxetine effect
# | enzyme | drug | level |
1 | 2D6 | alprenolol | Strong inhibitor |
2 | 2D6 | amitriptyline | Strong inhibitor |
3 | 2C19 | amitriptyline | Moderate inhibitor |
4 | 2D6 | amphetamine | Strong inhibitor |
5 | 2D6 | atomoxetine | Strong inhibitor |
6 | 2C19 | atomoxetine | Moderate inhibitor |
7 | 2D6 | brexpiprazole | Strong inhibitor |
8 | 2C19 | brivaracetam | Moderate inhibitor |
9 | 2D6 | bufuralol | Strong inhibitor |
10 | 2D6 | cariprazine | Strong inhibitor |
11 | 2C19 | carisoprodol | Moderate inhibitor |
12 | 2D6 | carvedilol | Strong inhibitor |
13 | 2C19 | celecoxib | Moderate inhibitor |
14 | 2C19 | chloramphenicol | Moderate inhibitor |
15 | 2D6 | chlorpheniramine | Strong inhibitor |
16 | 2D6 | chlorpromazine | Strong inhibitor |
17 | 2D6 | citalopram | Strong inhibitor |
18 | 2C19 | citalopram | Moderate inhibitor |
19 | 2C19 | clobazam | Moderate inhibitor |
20 | 2D6 | clomipramine | Strong inhibitor |
21 | 2C19 | clomipramine | Moderate inhibitor |
22 | 2D6 | clonidine | Strong inhibitor |
23 | 2C19 | clopidogrel | Moderate inhibitor |
24 | 2D6 | codeine | Strong inhibitor |
25 | 2C19 | cyclophosphamide | Moderate inhibitor |
26 | 2D6 | debrisoquine | Strong inhibitor |
27 | 2D6 | desipramine | Strong inhibitor |
28 | 2D6 | deutetrabenazine | Strong inhibitor |
29 | 2D6 | dexfenfluramine | Strong inhibitor |
30 | 2D6 | dextromethorphan | Strong inhibitor |
31 | 2C19 | diazepam | Moderate inhibitor |
32 | 2D6 | donepezil | Strong inhibitor |
33 | 2D6 | doxepin | Strong inhibitor |
34 | 2C19 | doxepin | Moderate inhibitor |
35 | 2D6 | eliglustat | Strong inhibitor |
36 | 2D6 | encainide | Strong inhibitor |
37 | 2D6 | escitalopram | Strong inhibitor |
38 | 2C19 | escitalopram | Moderate inhibitor |
39 | 2C19 | esomeprazole | Moderate inhibitor |
40 | 2D6 | flecainide | Strong inhibitor |
41 | 2C19 | flibanserin | Moderate inhibitor |
42 | 2D6 | fluoxetine | Strong inhibitor |
43 | 2D6 | fluvoxamine | Strong inhibitor |
44 | 2C19 | hexobarbital | Moderate inhibitor |
45 | 2D6 | ibrutinib | Strong inhibitor |
46 | 2D6 | imipramine | Strong inhibitor |
47 | 2C19 | imipramine | Moderate inhibitor |
48 | 2C19 | indomethacin | Moderate inhibitor |
49 | 2C19 | labetalol | Moderate inhibitor |
50 | 2C19 | lansoprazole | Moderate inhibitor |
51 | 2D6 | lidocaine | Strong inhibitor |
52 | 2C19 | mavacamten | Moderate inhibitor |
53 | 2D6 | metoclopramide | Strong inhibitor |
54 | 2D6 | metoprolol | Strong inhibitor |
55 | 2D6 | mexiletine | Strong inhibitor |
56 | 2D6 | minaprine | Strong inhibitor |
57 | 2C19 | moclobemide | Moderate inhibitor |
58 | 2D6 | nebivolol | Strong inhibitor |
59 | 2C19 | nelfinavir | Moderate inhibitor |
60 | 2C19 | nilutamide | Moderate inhibitor |
61 | 2D6 | nortriptyline | Strong inhibitor |
62 | 2C19 | omeprazole | Moderate inhibitor |
63 | 2D6 | ondansetron | Strong inhibitor |
64 | 2C19 | ospemifene | Moderate inhibitor |
65 | 2D6 | oxycodone | Strong inhibitor |
66 | 2C19 | pantoprazole | Moderate inhibitor |
67 | 2D6 | paroxetine | Strong inhibitor |
68 | 2D6 | perhexiline | Strong inhibitor |
69 | 2D6 | perphenazine | Strong inhibitor |
70 | 2D6 | phenacetin | Strong inhibitor |
71 | 2C19 | phenobarbitone | Moderate inhibitor |
72 | 2C19 | phenytoin | Moderate inhibitor |
73 | 2D6 | pimavanserin | Strong inhibitor |
74 | 2C19 | pomalidomide | Moderate inhibitor |
75 | 2D6 | ponatinib | Strong inhibitor |
76 | 2C19 | primidone | Moderate inhibitor |
77 | 2C19 | progesterone | Moderate inhibitor |
78 | 2C19 | proguanil | Moderate inhibitor |
79 | 2D6 | promethazine | Strong inhibitor |
80 | 2D6 | propafenone | Strong inhibitor |
81 | 2D6 | propranolol | Strong inhibitor |
82 | 2C19 | propranolol | Moderate inhibitor |
83 | 2C19 | r-mephobarbital | Moderate inhibitor |
84 | 2C19 | r-warfarin | Moderate inhibitor |
85 | 2D6 | risperidone | Strong inhibitor |
86 | 2D6 | rucaparib | Strong inhibitor |
87 | 2C19 | s-mephenytoin | Moderate inhibitor |
88 | 2D6 | sparteine | Strong inhibitor |
89 | 2C19 | suvorexant | Moderate inhibitor |
90 | 2D6 | tamoxifen | Strong inhibitor |
91 | 2C19 | teniposide | Moderate inhibitor |
92 | 2D6 | tetrabenzine | Strong inhibitor |
93 | 2D6 | thioridazine | Strong inhibitor |
94 | 2D6 | timolol | Strong inhibitor |
95 | 2C19 | tofacitinib | Moderate inhibitor |
96 | 2D6 | tramadol | Strong inhibitor |
97 | 2D6 | umeclidinium | Strong inhibitor |
98 | 2D6 | valbenazine | Strong inhibitor |
99 | 2D6 | venlafaxine | Strong inhibitor |
100 | 2C19 | venlafaxine | Moderate inhibitor |
101 | 2D6 | vilazodone | Strong inhibitor |
102 | 2C19 | vilazodone | Moderate inhibitor |
103 | 2C19 | voriconazole | Moderate inhibitor |
104 | 2D6 | zuclopenthixol | Strong inhibitor |
will
decrease fluoxetine effect
fluoxetine will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.