The following drugs will decrease modafinil effect

#

enzyme

inducers

the follwing drugs will Increase modafinil effect

#

enzyme

Inhibitors

level

The follwing drugs will Increase effect by modafinil effect

#	enzyme	drug	level
1	2C19	amitriptyline	Weak inhibitor
2	2C19	atomoxetine	Weak inhibitor
3	2C19	brivaracetam	Weak inhibitor
4	2C19	carisoprodol	Weak inhibitor
5	2C19	celecoxib	Weak inhibitor
6	2C19	chloramphenicol	Weak inhibitor
7	2C19	citalopram	Weak inhibitor
8	2C19	clobazam	Weak inhibitor
9	2C19	clomipramine	Weak inhibitor
10	2C19	clopidogrel	Weak inhibitor
11	2C19	cyclophosphamide	Weak inhibitor
12	2C19	diazepam	Weak inhibitor
13	2C19	doxepin	Weak inhibitor
14	2C19	escitalopram	Weak inhibitor
15	2C19	esomeprazole	Weak inhibitor
16	2C19	flibanserin	Weak inhibitor
17	2C19	hexobarbital	Weak inhibitor
18	2C19	imipramine	Weak inhibitor
19	2C19	indomethacin	Weak inhibitor
20	2C19	labetalol	Weak inhibitor
21	2C19	lansoprazole	Weak inhibitor
22	2C19	mavacamten	Weak inhibitor
23	2C19	moclobemide	Weak inhibitor
24	2C19	nelfinavir	Weak inhibitor
25	2C19	nilutamide	Weak inhibitor
26	2C19	omeprazole	Weak inhibitor
27	2C19	ospemifene	Weak inhibitor
28	2C19	pantoprazole	Weak inhibitor
29	2C19	phenobarbitone	Weak inhibitor
30	2C19	phenytoin	Weak inhibitor
31	2C19	pomalidomide	Weak inhibitor
32	2C19	primidone	Weak inhibitor
33	2C19	progesterone	Weak inhibitor
34	2C19	proguanil	Weak inhibitor
35	2C19	propranolol	Weak inhibitor
36	2C19	r-mephobarbital	Weak inhibitor
37	2C19	r-warfarin	Weak inhibitor
38	2C19	s-mephenytoin	Weak inhibitor
39	2C19	suvorexant	Weak inhibitor
40	2C19	teniposide	Weak inhibitor
41	2C19	tofacitinib	Weak inhibitor
42	2C19	venlafaxine	Weak inhibitor
43	2C19	vilazodone	Weak inhibitor
44	2C19	voriconazole	Weak inhibitor

The following drugs will decreased effect by modafinil effect

#	enzyme	drug
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	1A2	acetaminophen
5	3A457	alectinib
6	3A457	alfentanil
7	3A457	alprazolam
8	1A2	amitriptyline
9	3A457	amitriptyline
10	3A457	amlodipine
11	3A457	apixaban
12	1A2	apremilast
13	3A457	aprepitant
14	3A457	aripiprazole
15	3A457	astemizole
16	3A457	atorvastatin
17	3A457	avanafil
18	3A457	axitinib
19	3A457	boceprevir
20	3A457	bosutinib
21	3A457	brexpiprazole
22	3A457	brigatinib
23	3A457	buspirone
24	3A457	cafergot
25	1A2	caffeine
26	3A457	caffeine
27	3A457	carbamazepine
28	3A457	cariprazine
29	3A457	ceritinib
30	3A457	cerivastatin
31	3A457	chlorpheniramine
32	3A457	cilostazol
33	3A457	cisapride
34	3A457	citalopram
35	3A457	clarithromycin
36	3A457	clobazam
37	1A2	clomipramine
38	3A457	clopidogrel
39	1A2	clozapine
40	3A457	cobimetinib
41	3A457	cocaine
42	3A457	codeine
43	3A457	colchicine
44	3A457	copanlisib
45	3A457	crizotinib
46	1A2	cyclobenzaprine
47	3A457	cyclosporine
48	3A457	dabrafenib
49	3A457	daclatasvir
50	3A457	dapsone
51	3A457	deflazacort
52	3A457	dexamethasone
53	3A457	dextromethorphan
54	3A457	diazepam
55	3A457	diltiazem
56	3A457	docetaxel
57	3A457	dolutegravir
58	3A457	domperidone
59	1A2	doxepin
60	3A457	doxepin
61	1A2	duloxetine
62	3A457	elagolix
63	3A457	elbasvir/grazoprevir
64	3A457	eliglustat
65	3A457	enzalutamide
66	3A457	eplerenone
67	3A457	erythromycin2
68	3A457	escitalopram
69	3A457	esomeprazole
70	1A2	estradiol
71	3A457	estradiol
72	3A457	felodipine
73	3A457	fentanyl
74	3A457	finasteride
75	3A457	flibanserin
76	1A2	fluvoxamine
77	3A457	gleevec
78	1A2	haloperidol
79	3A457	haloperidol
80	3A457	hydrocortisone
81	3A457	ibrutinib
82	3A457	idelalisib
83	1A2	imipramine
84	3A457	indacaterol
85	3A457	indinavir
86	3A457	irinotecan
87	3A457	isavuconazonium
88	3A457	ivabradine
89	3A457	ivacaftor
90	3A457	LAAM
91	3A457	lansoprazole
92	3A457	lenvatinib
93	3A457	lercanidipine
94	3A457	lidocaine
95	3A457	linagliptin
96	3A457	lovastatin
97	3A457	macitentan
98	3A457	mavacamten
99	3A457	methadone
100	1A2	mexiletine
101	3A457	midazolam
102	1A2	nabumetone
103	3A457	naldemedine
104	3A457	naloxegol
105	1A2	naproxen
106	3A457	nateglinide
107	3A457	nelfinavir
108	3A457	neratinib
109	3A457	netupitant/palonosetron
110	3A457	nevirapine
111	3A457	nifedipine
112	3A457	nirmatrelvir
113	3A457	nisoldipine
114	3A457	nitrendipine
115	1A2	olanzapine
116	3A457	olaparib
117	3A457	omeprazole
118	1A2	ondansetron
119	3A457	ondansetron
120	3A457	osimertinib
121	3A457	ospemifene
122	3A457	palbociclib
123	3A457	panobinostat
124	3A457	pantoprazole
125	3A457	perampanel
126	1A2	phenacetin
127	3A457	pimavanserin
128	3A457	pimozide
129	1A2	pirfenidone
130	1A2	pomalidomide
131	3A457	pomalidomide
132	3A457	ponatinib
133	3A457	progesterone
134	1A2	propranolol
135	3A457	propranolol
136	3A457	quetiapine
137	3A457	quinidine
138	3A457	quinine
139	3A457	regorafenib
140	3A457	ribociclib
141	3A457	rilpivirine
142	1A2	riluzole
143	3A457	risperidone
144	3A457	ritonavir
145	3A457	rivaroxaban
146	1A2	roflumilast
147	3A457	roflumilast
148	3A457	rolapitant
149	3A457	romidepsin
150	1A2	ropivacaine
151	1A2	rucaparib
152	3A457	rucaparib
153	3A457	ruxolitinib
154	3A457	salmeterol
155	3A457	saquinavir
156	3A457	selexipag
157	3A457	sildenafil
158	3A457	simeprevir
159	3A457	simvastatin
160	3A457	sirolimus
161	3A457	sonidegib
162	3A457	sorafenib
163	3A457	sunitinib
164	3A457	suvorexant
165	1A2	tacrine
166	3A457	tacrolimus(fk506)
167	3A457	tamoxifen
168	1A2	tasimelteon
169	3A457	tasimelteon
170	3A457	taxol
171	3A457	telaprevir
172	3A457	telithromycin
173	3A457	terfenadine
174	3A457	testosterone
175	1A2	theophylline
176	3A457	ticagrelor
177	1A2	tizanidine
178	3A457	tofacitinib
179	3A457	tolvaptan
180	3A457	torisel
181	3A457	tramadol
182	3A457	trazodone
183	1A2	triamterene
184	3A457	valbenazine
185	3A457	vandetanib
186	3A457	velpatasvir
187	3A457	vemurafenib
188	3A457	venetoclax
189	3A457	venlafaxine
190	1A2	verapamil
191	3A457	verapamil
192	3A457	vilazodone
193	3A457	vincristine
194	3A457	vorapaxar
195	3A457	voriconazole
196	1A2	warfarin
197	3A457	zaleplon
198	1A2	zileuton
199	3A457	ziprasidone
200	1A2	zolmitriptan
201	3A457	zolpidem

will decrease modafinil effect

#

enzyme

inducers

modafinil will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.