The following drugs will decrease esomeprazole effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	2C19	carbamazepine
3	3A457	carbamazepine
4	3A457	clobazam
5	3A457	dabrafenib
6	2C19	efavirenz
7	3A457	efavirenz
8	2C19	enzalutamide
9	3A457	elagolix
10	3A457	enzalutamide
11	2C19	letermovir
12	3A457	eslicarbazepine
13	3A457	glucocorticoids
14	3A457	letermovir
15	3A457	lorlatinib
16	3A457	modafinil
17	3A457	nevirapine
18	3A457	oxcarbazepine
19	3A457	perampanel
20	2C19	prednisone
21	2C19	rifampicin
22	3A457	phenobarbital
23	2C19	ritonavir
24	3A457	phenytoin
25	3A457	pioglitazone
26	3A457	rifabutin
27	3A457	rifampin
28	3A457	St. John's Wort
29	3A457	telotristat
30	3A457	troglitazone
31	3A457	vemurafenib

the follwing drugs will Increase esomeprazole effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	2C19	armodafinil	Weak inhibitor
3	3A457	atomoxetine
4	3A457	boceprevir	under review
5	3A457	ceritinib	Strong inhibitor
6	2C19	chloramphenicol	In-Vitro Only
7	3A457	chloramphenicol	In-Vitro Only
8	2C19	cimetidine	Weak inhibitor
9	3A457	cimetidine
10	3A457	ciprofloxacin	under review
11	2C19	citalopram	Weak inhibitor
12	3A457	clarithromycin	Strong inhibitor
13	3A457	crizotinib	Moderate inhibitor
14	3A457	delaviridine	under review
15	3A457	diethyl-dithiocarbamate
16	3A457	diltiazem	Moderate inhibitor
17	3A457	entrectinib
18	3A457	erythromycin	Moderate inhibitor
19	3A457	esomeprazole
20	2C19	felbamate	Weak inhibitor
21	2C19	fluconazole	Moderate inhibitor
22	3A457	fluconazole	Moderate inhibitor
23	2C19	fluoxetine	Moderate inhibitor
24	2C19	fluvoxamine	Strong inhibitor
25	3A457	fluvoxamine	under review
26	3A457	gestodene	under review
27	3A457	grapefruit juice	Moderate inhibitor
28	3A457	idelalisib	Strong inhibitor
29	3A457	imatinib	under review
30	3A457	indinavir	Strong inhibitor
31	2C19	isoniazid	Weak inhibitor
32	3A457	itraconazole	Strong inhibitor
33	3A457	ivacaftor
34	2C19	ketoconazole	Moderate inhibitor
35	3A457	ketoconazole	Strong inhibitor
36	3A457	lesinurad
37	3A457	letermovir
38	2C19	luliconazole	Weak inhibitor
39	3A457	mibefradil	Strong inhibitor
40	3A457	mifepristone	under review
41	2C19	modafinil	Weak inhibitor
42	3A457	nefazodone	Strong inhibitor
43	3A457	nelfinavir	Strong inhibitor
44	3A457	netupitant/palonosetron	Moderate inhibitor
45	3A457	norfloxacin	under review
46	3A457	norfluoxetine	under review
47	2C19	omeprazole	Weak inhibitor
48	3A457	omeprazole	Weak inhibitor
49	2C19	oral contraceptives	Weak inhibitor
50	2C19	oritavancin	In-Vitro Only
51	2C19	pantoprazole	Weak inhibitor
52	3A457	pantoprazole
53	3A457	perampanel
54	2C19	quercetin	In-Vitro Only
55	3A457	quercetin
56	3A457	regorafenib	under review
57	3A457	ribociclib	Strong inhibitor
58	3A457	ritonavir	Strong inhibitor
59	3A457	rucaparib
60	3A457	saquinavir	Strong inhibitor
61	3A457	simeprevir
62	3A457	starfruit	under review
63	3A457	telaprevir	under review
64	3A457	telithromycin	Strong inhibitor
65	3A457	ticagrelor
66	2C19	ticlopidine	Strong inhibitor
67	2C19	topiramate	under review
68	3A457	tucatinib	Strong inhibitor
69	3A457	verapamil	Moderate inhibitor
70	2C19	voriconazole	Moderate inhibitor
71	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by esomeprazole effect

#	enzyme	drug	level
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	3A457	alectinib
5	3A457	alfentanil
6	3A457	alprazolam
7	2C19	amitriptyline	Weak inhibitor
8	3A457	amitriptyline
9	3A457	amlodipine
10	3A457	apixaban
11	3A457	aprepitant
12	3A457	aripiprazole
13	3A457	astemizole
14	2C19	atomoxetine	Weak inhibitor
15	3A457	atorvastatin
16	3A457	avanafil
17	3A457	axitinib
18	3A457	boceprevir
19	3A457	bosutinib
20	3A457	brexpiprazole
21	3A457	brigatinib
22	2C19	brivaracetam	Weak inhibitor
23	3A457	buspirone
24	3A457	cafergot
25	3A457	caffeine
26	3A457	carbamazepine
27	3A457	cariprazine
28	2C19	carisoprodol	Weak inhibitor
29	2C19	celecoxib	Weak inhibitor
30	3A457	ceritinib
31	3A457	cerivastatin
32	2C19	chloramphenicol	Weak inhibitor
33	3A457	chlorpheniramine
34	3A457	cilostazol
35	3A457	cisapride
36	2C19	citalopram	Weak inhibitor
37	3A457	citalopram
38	3A457	clarithromycin
39	2C19	clobazam	Weak inhibitor
40	3A457	clobazam
41	2C19	clomipramine	Weak inhibitor
42	2C19	clopidogrel	Weak inhibitor
43	3A457	clopidogrel
44	3A457	cobimetinib
45	3A457	cocaine
46	3A457	codeine
47	3A457	colchicine
48	3A457	copanlisib
49	3A457	crizotinib
50	2C19	cyclophosphamide	Weak inhibitor
51	3A457	cyclosporine
52	3A457	dabrafenib
53	3A457	daclatasvir
54	3A457	dapsone
55	3A457	deflazacort
56	3A457	dexamethasone
57	3A457	dextromethorphan
58	2C19	diazepam	Weak inhibitor
59	3A457	diazepam
60	3A457	diltiazem
61	3A457	docetaxel
62	3A457	dolutegravir
63	3A457	domperidone
64	2C19	doxepin	Weak inhibitor
65	3A457	doxepin
66	3A457	elagolix
67	3A457	elbasvir/grazoprevir
68	3A457	eliglustat
69	3A457	enzalutamide
70	3A457	eplerenone
71	3A457	erythromycin2
72	2C19	escitalopram	Weak inhibitor
73	3A457	escitalopram
74	3A457	esomeprazole
75	3A457	estradiol
76	3A457	felodipine
77	3A457	fentanyl
78	3A457	finasteride
79	2C19	flibanserin	Weak inhibitor
80	3A457	flibanserin
81	3A457	gleevec
82	3A457	haloperidol
83	2C19	hexobarbital	Weak inhibitor
84	3A457	hydrocortisone
85	3A457	ibrutinib
86	3A457	idelalisib
87	2C19	imipramine	Weak inhibitor
88	3A457	indacaterol
89	3A457	indinavir
90	2C19	indomethacin	Weak inhibitor
91	3A457	irinotecan
92	3A457	isavuconazonium
93	3A457	ivabradine
94	3A457	ivacaftor
95	3A457	LAAM
96	2C19	labetalol	Weak inhibitor
97	2C19	lansoprazole	Weak inhibitor
98	3A457	lansoprazole
99	3A457	lenvatinib
100	3A457	lercanidipine
101	3A457	lidocaine
102	3A457	linagliptin
103	3A457	lovastatin
104	3A457	macitentan
105	2C19	mavacamten	Weak inhibitor
106	3A457	mavacamten
107	3A457	methadone
108	3A457	midazolam
109	2C19	moclobemide	Weak inhibitor
110	3A457	naldemedine
111	3A457	naloxegol
112	3A457	nateglinide
113	2C19	nelfinavir	Weak inhibitor
114	3A457	nelfinavir
115	3A457	neratinib
116	3A457	netupitant/palonosetron
117	3A457	nevirapine
118	3A457	nifedipine
119	2C19	nilutamide	Weak inhibitor
120	3A457	nirmatrelvir
121	3A457	nisoldipine
122	3A457	nitrendipine
123	3A457	olaparib
124	2C19	omeprazole	Weak inhibitor
125	3A457	omeprazole
126	3A457	ondansetron
127	3A457	osimertinib
128	2C19	ospemifene	Weak inhibitor
129	3A457	ospemifene
130	3A457	palbociclib
131	3A457	panobinostat
132	2C19	pantoprazole	Weak inhibitor
133	3A457	pantoprazole
134	3A457	perampanel
135	2C19	phenobarbitone	Weak inhibitor
136	2C19	phenytoin	Weak inhibitor
137	3A457	pimavanserin
138	3A457	pimozide
139	2C19	pomalidomide	Weak inhibitor
140	3A457	pomalidomide
141	3A457	ponatinib
142	2C19	primidone	Weak inhibitor
143	2C19	progesterone	Weak inhibitor
144	3A457	progesterone
145	2C19	proguanil	Weak inhibitor
146	2C19	propranolol	Weak inhibitor
147	3A457	propranolol
148	3A457	quetiapine
149	3A457	quinidine
150	3A457	quinine
151	2C19	r-mephobarbital	Weak inhibitor
152	2C19	r-warfarin	Weak inhibitor
153	3A457	regorafenib
154	3A457	ribociclib
155	3A457	rilpivirine
156	3A457	risperidone
157	3A457	ritonavir
158	3A457	rivaroxaban
159	3A457	roflumilast
160	3A457	rolapitant
161	3A457	romidepsin
162	3A457	rucaparib
163	3A457	ruxolitinib
164	2C19	s-mephenytoin	Weak inhibitor
165	3A457	salmeterol
166	3A457	saquinavir
167	3A457	selexipag
168	3A457	sildenafil
169	3A457	simeprevir
170	3A457	simvastatin
171	3A457	sirolimus
172	3A457	sonidegib
173	3A457	sorafenib
174	3A457	sunitinib
175	2C19	suvorexant	Weak inhibitor
176	3A457	suvorexant
177	3A457	tacrolimus(fk506)
178	3A457	tamoxifen
179	3A457	tasimelteon
180	3A457	taxol
181	3A457	telaprevir
182	3A457	telithromycin
183	2C19	teniposide	Weak inhibitor
184	3A457	terfenadine
185	3A457	testosterone
186	3A457	ticagrelor
187	2C19	tofacitinib	Weak inhibitor
188	3A457	tofacitinib
189	3A457	tolvaptan
190	3A457	torisel
191	3A457	tramadol
192	3A457	trazodone
193	3A457	valbenazine
194	3A457	vandetanib
195	3A457	velpatasvir
196	3A457	vemurafenib
197	3A457	venetoclax
198	2C19	venlafaxine	Weak inhibitor
199	3A457	venlafaxine
200	3A457	verapamil
201	2C19	vilazodone	Weak inhibitor
202	3A457	vilazodone
203	3A457	vincristine
204	3A457	vorapaxar
205	2C19	voriconazole	Weak inhibitor
206	3A457	voriconazole
207	3A457	zaleplon
208	3A457	ziprasidone
209	3A457	zolpidem

will decrease esomeprazole effect

#

enzyme

inducers

esomeprazole will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.