ketoconazole
The following drugs will decrease ketoconazole effect
the follwing drugs will
Increase ketoconazole effect
The follwing drugs will Increase effect by ketoconazole effect
| # | enzyme | drug | level |
| 1 | 3A457 | abemaciclib | Strong inhibitor |
| 2 | 3A457 | abiraterone | Strong inhibitor |
| 3 | 3A457 | acalabrutinib | Strong inhibitor |
| 4 | 3A457 | alectinib | Strong inhibitor |
| 5 | 3A457 | alfentanil | Strong inhibitor |
| 6 | 3A457 | alprazolam | Strong inhibitor |
| 7 | 2C19 | amitriptyline | Moderate inhibitor |
| 8 | 3A457 | amitriptyline | Strong inhibitor |
| 9 | 3A457 | amlodipine | Strong inhibitor |
| 10 | 3A457 | apixaban | Strong inhibitor |
| 11 | 3A457 | aprepitant | Strong inhibitor |
| 12 | 3A457 | aripiprazole | Strong inhibitor |
| 13 | 3A457 | astemizole | Strong inhibitor |
| 14 | 2C19 | atomoxetine | Moderate inhibitor |
| 15 | 3A457 | atorvastatin | Strong inhibitor |
| 16 | 3A457 | avanafil | Strong inhibitor |
| 17 | 3A457 | axitinib | Strong inhibitor |
| 18 | 3A457 | boceprevir | Strong inhibitor |
| 19 | 3A457 | bosutinib | Strong inhibitor |
| 20 | 3A457 | brexpiprazole | Strong inhibitor |
| 21 | 3A457 | brigatinib | Strong inhibitor |
| 22 | 2C19 | brivaracetam | Moderate inhibitor |
| 23 | 3A457 | buspirone | Strong inhibitor |
| 24 | 3A457 | cafergot | Strong inhibitor |
| 25 | 3A457 | caffeine | Strong inhibitor |
| 26 | 3A457 | carbamazepine | Strong inhibitor |
| 27 | 3A457 | cariprazine | Strong inhibitor |
| 28 | 2C19 | carisoprodol | Moderate inhibitor |
| 29 | 2C19 | celecoxib | Moderate inhibitor |
| 30 | 3A457 | ceritinib | Strong inhibitor |
| 31 | 3A457 | cerivastatin | Strong inhibitor |
| 32 | 2C19 | chloramphenicol | Moderate inhibitor |
| 33 | 3A457 | chlorpheniramine | Strong inhibitor |
| 34 | 3A457 | cilostazol | Strong inhibitor |
| 35 | 3A457 | cisapride | Strong inhibitor |
| 36 | 2C19 | citalopram | Moderate inhibitor |
| 37 | 3A457 | citalopram | Strong inhibitor |
| 38 | 3A457 | clarithromycin | Strong inhibitor |
| 39 | 2C19 | clobazam | Moderate inhibitor |
| 40 | 3A457 | clobazam | Strong inhibitor |
| 41 | 2C19 | clomipramine | Moderate inhibitor |
| 42 | 2C19 | clopidogrel | Moderate inhibitor |
| 43 | 3A457 | clopidogrel | Strong inhibitor |
| 44 | 3A457 | cobimetinib | Strong inhibitor |
| 45 | 3A457 | cocaine | Strong inhibitor |
| 46 | 3A457 | codeine | Strong inhibitor |
| 47 | 3A457 | colchicine | Strong inhibitor |
| 48 | 3A457 | copanlisib | Strong inhibitor |
| 49 | 3A457 | crizotinib | Strong inhibitor |
| 50 | 2C19 | cyclophosphamide | Moderate inhibitor |
| 51 | 3A457 | cyclosporine | Strong inhibitor |
| 52 | 3A457 | dabrafenib | Strong inhibitor |
| 53 | 3A457 | daclatasvir | Strong inhibitor |
| 54 | 3A457 | dapsone | Strong inhibitor |
| 55 | 3A457 | deflazacort | Strong inhibitor |
| 56 | 3A457 | dexamethasone | Strong inhibitor |
| 57 | 3A457 | dextromethorphan | Strong inhibitor |
| 58 | 2C19 | diazepam | Moderate inhibitor |
| 59 | 3A457 | diazepam | Strong inhibitor |
| 60 | 3A457 | diltiazem | Strong inhibitor |
| 61 | 3A457 | docetaxel | Strong inhibitor |
| 62 | 3A457 | dolutegravir | Strong inhibitor |
| 63 | 3A457 | domperidone | Strong inhibitor |
| 64 | 2C19 | doxepin | Moderate inhibitor |
| 65 | 3A457 | doxepin | Strong inhibitor |
| 66 | 3A457 | elagolix | Strong inhibitor |
| 67 | 3A457 | elbasvir/grazoprevir | Strong inhibitor |
| 68 | 3A457 | eliglustat | Strong inhibitor |
| 69 | 3A457 | enzalutamide | Strong inhibitor |
| 70 | 3A457 | eplerenone | Strong inhibitor |
| 71 | 3A457 | erythromycin2 | Strong inhibitor |
| 72 | 2C19 | escitalopram | Moderate inhibitor |
| 73 | 3A457 | escitalopram | Strong inhibitor |
| 74 | 2C19 | esomeprazole | Moderate inhibitor |
| 75 | 3A457 | esomeprazole | Strong inhibitor |
| 76 | 3A457 | estradiol | Strong inhibitor |
| 77 | 3A457 | felodipine | Strong inhibitor |
| 78 | 3A457 | fentanyl | Strong inhibitor |
| 79 | 3A457 | finasteride | Strong inhibitor |
| 80 | 2C19 | flibanserin | Moderate inhibitor |
| 81 | 3A457 | flibanserin | Strong inhibitor |
| 82 | 3A457 | gleevec | Strong inhibitor |
| 83 | 3A457 | haloperidol | Strong inhibitor |
| 84 | 2C19 | hexobarbital | Moderate inhibitor |
| 85 | 3A457 | hydrocortisone | Strong inhibitor |
| 86 | 3A457 | ibrutinib | Strong inhibitor |
| 87 | 3A457 | idelalisib | Strong inhibitor |
| 88 | 2C19 | imipramine | Moderate inhibitor |
| 89 | 3A457 | indacaterol | Strong inhibitor |
| 90 | 3A457 | indinavir | Strong inhibitor |
| 91 | 2C19 | indomethacin | Moderate inhibitor |
| 92 | 3A457 | irinotecan | Strong inhibitor |
| 93 | 3A457 | isavuconazonium | Strong inhibitor |
| 94 | 3A457 | ivabradine | Strong inhibitor |
| 95 | 3A457 | ivacaftor | Strong inhibitor |
| 96 | 3A457 | LAAM | Strong inhibitor |
| 97 | 2C19 | labetalol | Moderate inhibitor |
| 98 | 2C19 | lansoprazole | Moderate inhibitor |
| 99 | 3A457 | lansoprazole | Strong inhibitor |
| 100 | 3A457 | lenvatinib | Strong inhibitor |
| 101 | 3A457 | lercanidipine | Strong inhibitor |
| 102 | 3A457 | lidocaine | Strong inhibitor |
| 103 | 3A457 | linagliptin | Strong inhibitor |
| 104 | 3A457 | lovastatin | Strong inhibitor |
| 105 | 3A457 | macitentan | Strong inhibitor |
| 106 | 2C19 | mavacamten | Moderate inhibitor |
| 107 | 3A457 | mavacamten | Strong inhibitor |
| 108 | 3A457 | methadone | Strong inhibitor |
| 109 | 3A457 | midazolam | Strong inhibitor |
| 110 | 2C19 | moclobemide | Moderate inhibitor |
| 111 | 3A457 | naldemedine | Strong inhibitor |
| 112 | 3A457 | naloxegol | Strong inhibitor |
| 113 | 3A457 | nateglinide | Strong inhibitor |
| 114 | 2C19 | nelfinavir | Moderate inhibitor |
| 115 | 3A457 | nelfinavir | Strong inhibitor |
| 116 | 3A457 | neratinib | Strong inhibitor |
| 117 | 3A457 | netupitant/palonosetron | Strong inhibitor |
| 118 | 3A457 | nevirapine | Strong inhibitor |
| 119 | 3A457 | nifedipine | Strong inhibitor |
| 120 | 2C19 | nilutamide | Moderate inhibitor |
| 121 | 3A457 | nirmatrelvir | Strong inhibitor |
| 122 | 3A457 | nisoldipine | Strong inhibitor |
| 123 | 3A457 | nitrendipine | Strong inhibitor |
| 124 | 3A457 | olaparib | Strong inhibitor |
| 125 | 2C19 | omeprazole | Moderate inhibitor |
| 126 | 3A457 | omeprazole | Strong inhibitor |
| 127 | 3A457 | ondansetron | Strong inhibitor |
| 128 | 3A457 | osimertinib | Strong inhibitor |
| 129 | 2C19 | ospemifene | Moderate inhibitor |
| 130 | 3A457 | ospemifene | Strong inhibitor |
| 131 | 3A457 | palbociclib | Strong inhibitor |
| 132 | 3A457 | panobinostat | Strong inhibitor |
| 133 | 2C19 | pantoprazole | Moderate inhibitor |
| 134 | 3A457 | pantoprazole | Strong inhibitor |
| 135 | 3A457 | perampanel | Strong inhibitor |
| 136 | 2C19 | phenobarbitone | Moderate inhibitor |
| 137 | 2C19 | phenytoin | Moderate inhibitor |
| 138 | 3A457 | pimavanserin | Strong inhibitor |
| 139 | 3A457 | pimozide | Strong inhibitor |
| 140 | 2C19 | pomalidomide | Moderate inhibitor |
| 141 | 3A457 | pomalidomide | Strong inhibitor |
| 142 | 3A457 | ponatinib | Strong inhibitor |
| 143 | 2C19 | primidone | Moderate inhibitor |
| 144 | 2C19 | progesterone | Moderate inhibitor |
| 145 | 3A457 | progesterone | Strong inhibitor |
| 146 | 2C19 | proguanil | Moderate inhibitor |
| 147 | 2C19 | propranolol | Moderate inhibitor |
| 148 | 3A457 | propranolol | Strong inhibitor |
| 149 | 3A457 | quetiapine | Strong inhibitor |
| 150 | 3A457 | quinidine | Strong inhibitor |
| 151 | 3A457 | quinine | Strong inhibitor |
| 152 | 2C19 | r-mephobarbital | Moderate inhibitor |
| 153 | 2C19 | r-warfarin | Moderate inhibitor |
| 154 | 3A457 | regorafenib | Strong inhibitor |
| 155 | 3A457 | ribociclib | Strong inhibitor |
| 156 | 3A457 | rilpivirine | Strong inhibitor |
| 157 | 3A457 | risperidone | Strong inhibitor |
| 158 | 3A457 | ritonavir | Strong inhibitor |
| 159 | 3A457 | rivaroxaban | Strong inhibitor |
| 160 | 3A457 | roflumilast | Strong inhibitor |
| 161 | 3A457 | rolapitant | Strong inhibitor |
| 162 | 3A457 | romidepsin | Strong inhibitor |
| 163 | 3A457 | rucaparib | Strong inhibitor |
| 164 | 3A457 | ruxolitinib | Strong inhibitor |
| 165 | 2C19 | s-mephenytoin | Moderate inhibitor |
| 166 | 3A457 | salmeterol | Strong inhibitor |
| 167 | 3A457 | saquinavir | Strong inhibitor |
| 168 | 3A457 | selexipag | Strong inhibitor |
| 169 | 3A457 | sildenafil | Strong inhibitor |
| 170 | 3A457 | simeprevir | Strong inhibitor |
| 171 | 3A457 | simvastatin | Strong inhibitor |
| 172 | 3A457 | sirolimus | Strong inhibitor |
| 173 | 3A457 | sonidegib | Strong inhibitor |
| 174 | 3A457 | sorafenib | Strong inhibitor |
| 175 | 3A457 | sunitinib | Strong inhibitor |
| 176 | 2C19 | suvorexant | Moderate inhibitor |
| 177 | 3A457 | suvorexant | Strong inhibitor |
| 178 | 3A457 | tacrolimus(fk506) | Strong inhibitor |
| 179 | 3A457 | tamoxifen | Strong inhibitor |
| 180 | 3A457 | tasimelteon | Strong inhibitor |
| 181 | 3A457 | taxol | Strong inhibitor |
| 182 | 3A457 | telaprevir | Strong inhibitor |
| 183 | 3A457 | telithromycin | Strong inhibitor |
| 184 | 2C19 | teniposide | Moderate inhibitor |
| 185 | 3A457 | terfenadine | Strong inhibitor |
| 186 | 3A457 | testosterone | Strong inhibitor |
| 187 | 3A457 | ticagrelor | Strong inhibitor |
| 188 | 2C19 | tofacitinib | Moderate inhibitor |
| 189 | 3A457 | tofacitinib | Strong inhibitor |
| 190 | 3A457 | tolvaptan | Strong inhibitor |
| 191 | 3A457 | torisel | Strong inhibitor |
| 192 | 3A457 | tramadol | Strong inhibitor |
| 193 | 3A457 | trazodone | Strong inhibitor |
| 194 | 3A457 | valbenazine | Strong inhibitor |
| 195 | 3A457 | vandetanib | Strong inhibitor |
| 196 | 3A457 | velpatasvir | Strong inhibitor |
| 197 | 3A457 | vemurafenib | Strong inhibitor |
| 198 | 3A457 | venetoclax | Strong inhibitor |
| 199 | 2C19 | venlafaxine | Moderate inhibitor |
| 200 | 3A457 | venlafaxine | Strong inhibitor |
| 201 | 3A457 | verapamil | Strong inhibitor |
| 202 | 2C19 | vilazodone | Moderate inhibitor |
| 203 | 3A457 | vilazodone | Strong inhibitor |
| 204 | 3A457 | vincristine | Strong inhibitor |
| 205 | 3A457 | vorapaxar | Strong inhibitor |
| 206 | 2C19 | voriconazole | Moderate inhibitor |
| 207 | 3A457 | voriconazole | Strong inhibitor |
| 208 | 3A457 | zaleplon | Strong inhibitor |
| 209 | 3A457 | ziprasidone | Strong inhibitor |
| 210 | 3A457 | zolpidem | Strong inhibitor |
will
decrease ketoconazole effect
ketoconazole will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.