topiramate
The following drugs will decrease topiramate effect
the follwing drugs will
Increase topiramate effect
The follwing drugs will Increase effect by topiramate effect
| # | enzyme | drug | level |
| 1 | 2C19 | amitriptyline | under review |
| 2 | 2C19 | atomoxetine | under review |
| 3 | 2C19 | brivaracetam | under review |
| 4 | 2C19 | carisoprodol | under review |
| 5 | 2C19 | celecoxib | under review |
| 6 | 2C19 | chloramphenicol | under review |
| 7 | 2C19 | citalopram | under review |
| 8 | 2C19 | clobazam | under review |
| 9 | 2C19 | clomipramine | under review |
| 10 | 2C19 | clopidogrel | under review |
| 11 | 2C19 | cyclophosphamide | under review |
| 12 | 2C19 | diazepam | under review |
| 13 | 2C19 | doxepin | under review |
| 14 | 2C19 | escitalopram | under review |
| 15 | 2C19 | esomeprazole | under review |
| 16 | 2C19 | flibanserin | under review |
| 17 | 2C19 | hexobarbital | under review |
| 18 | 2C19 | imipramine | under review |
| 19 | 2C19 | indomethacin | under review |
| 20 | 2C19 | labetalol | under review |
| 21 | 2C19 | lansoprazole | under review |
| 22 | 2C19 | mavacamten | under review |
| 23 | 2C19 | moclobemide | under review |
| 24 | 2C19 | nelfinavir | under review |
| 25 | 2C19 | nilutamide | under review |
| 26 | 2C19 | omeprazole | under review |
| 27 | 2C19 | ospemifene | under review |
| 28 | 2C19 | pantoprazole | under review |
| 29 | 2C19 | phenobarbitone | under review |
| 30 | 2C19 | phenytoin | under review |
| 31 | 2C19 | pomalidomide | under review |
| 32 | 2C19 | primidone | under review |
| 33 | 2C19 | progesterone | under review |
| 34 | 2C19 | proguanil | under review |
| 35 | 2C19 | propranolol | under review |
| 36 | 2C19 | r-mephobarbital | under review |
| 37 | 2C19 | r-warfarin | under review |
| 38 | 2C19 | s-mephenytoin | under review |
| 39 | 2C19 | suvorexant | under review |
| 40 | 2C19 | teniposide | under review |
| 41 | 2C19 | tofacitinib | under review |
| 42 | 2C19 | venlafaxine | under review |
| 43 | 2C19 | vilazodone | under review |
| 44 | 2C19 | voriconazole | under review |
will
decrease topiramate effect
topiramate will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.