The following drugs will decrease lesinurad effect

#	enzyme	inducers
0	2C9	carbamazepine
1	2C9	dabrafenib
2	2C9	enzalutamide
3	2C9	letermovir
4	2C9	nevirapine
5	2C9	phenobarbital
6	2C9	rifampin
7	2C9	secobarbital

the follwing drugs will Increase lesinurad effect

#	enzyme	Inhibitors	level
0	2C9	amiodarone	Moderate inhibitor
1	2C9	capecitabine	Weak inhibitor
2	2C9	ceritinib	Weak inhibitor
3	2C9	efavirenz	Weak inhibitor
4	2C9	fenofibrate	In-Vitro Only
5	2C9	fluconazole	Moderate inhibitor
6	2C9	fluvastatin	In-Vitro Only
7	2C9	fluvoxamine	In-Vitro Only
8	2C9	isoniazid	Weak inhibitor
9	2C9	metronidazole	Moderate inhibitor
10	2C9	phenylbutazone	Moderate inhibitor
11	2C9	quercetin	Weak inhibitor
12	2C9	sulfamethoxazole	Weak inhibitor
13	2C9	sulfaphenazole	Strong inhibitor
14	2C9	voriconazole	Weak inhibitor
15	2C9	zafirlukast	Weak inhibitor

The follwing drugs will Increase effect by lesinurad effect

#	enzyme	drug	level
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	3A457	alectinib
5	3A457	alfentanil
6	3A457	alprazolam
7	3A457	amitriptyline
8	3A457	amlodipine
9	3A457	apixaban
10	3A457	aprepitant
11	3A457	aripiprazole
12	3A457	astemizole
13	3A457	atorvastatin
14	3A457	avanafil
15	3A457	axitinib
16	3A457	boceprevir
17	3A457	bosutinib
18	3A457	brexpiprazole
19	3A457	brigatinib
20	3A457	buspirone
21	3A457	cafergot
22	3A457	caffeine
23	3A457	carbamazepine
24	3A457	cariprazine
25	3A457	ceritinib
26	3A457	cerivastatin
27	3A457	chlorpheniramine
28	3A457	cilostazol
29	3A457	cisapride
30	3A457	citalopram
31	3A457	clarithromycin
32	3A457	clobazam
33	3A457	clopidogrel
34	3A457	cobimetinib
35	3A457	cocaine
36	3A457	codeine
37	3A457	colchicine
38	3A457	copanlisib
39	3A457	crizotinib
40	3A457	cyclosporine
41	3A457	dabrafenib
42	3A457	daclatasvir
43	3A457	dapsone
44	3A457	deflazacort
45	3A457	dexamethasone
46	3A457	dextromethorphan
47	3A457	diazepam
48	3A457	diltiazem
49	3A457	docetaxel
50	3A457	dolutegravir
51	3A457	domperidone
52	3A457	doxepin
53	3A457	elagolix
54	3A457	elbasvir/grazoprevir
55	3A457	eliglustat
56	3A457	enzalutamide
57	3A457	eplerenone
58	3A457	erythromycin2
59	3A457	escitalopram
60	3A457	esomeprazole
61	3A457	estradiol
62	3A457	felodipine
63	3A457	fentanyl
64	3A457	finasteride
65	3A457	flibanserin
66	3A457	gleevec
67	3A457	haloperidol
68	3A457	hydrocortisone
69	3A457	ibrutinib
70	3A457	idelalisib
71	3A457	indacaterol
72	3A457	indinavir
73	3A457	irinotecan
74	3A457	isavuconazonium
75	3A457	ivabradine
76	3A457	ivacaftor
77	3A457	LAAM
78	3A457	lansoprazole
79	3A457	lenvatinib
80	3A457	lercanidipine
81	3A457	lidocaine
82	3A457	linagliptin
83	3A457	lovastatin
84	3A457	macitentan
85	3A457	mavacamten
86	3A457	methadone
87	3A457	midazolam
88	3A457	naldemedine
89	3A457	naloxegol
90	3A457	nateglinide
91	3A457	nelfinavir
92	3A457	neratinib
93	3A457	netupitant/palonosetron
94	3A457	nevirapine
95	3A457	nifedipine
96	3A457	nirmatrelvir
97	3A457	nisoldipine
98	3A457	nitrendipine
99	3A457	olaparib
100	3A457	omeprazole
101	3A457	ondansetron
102	3A457	osimertinib
103	3A457	ospemifene
104	3A457	palbociclib
105	3A457	panobinostat
106	3A457	pantoprazole
107	3A457	perampanel
108	3A457	pimavanserin
109	3A457	pimozide
110	3A457	pomalidomide
111	3A457	ponatinib
112	3A457	progesterone
113	3A457	propranolol
114	3A457	quetiapine
115	3A457	quinidine
116	3A457	quinine
117	3A457	regorafenib
118	3A457	ribociclib
119	3A457	rilpivirine
120	3A457	risperidone
121	3A457	ritonavir
122	3A457	rivaroxaban
123	3A457	roflumilast
124	3A457	rolapitant
125	3A457	romidepsin
126	3A457	rucaparib
127	3A457	ruxolitinib
128	3A457	salmeterol
129	3A457	saquinavir
130	3A457	selexipag
131	3A457	sildenafil
132	3A457	simeprevir
133	3A457	simvastatin
134	3A457	sirolimus
135	3A457	sonidegib
136	3A457	sorafenib
137	3A457	sunitinib
138	3A457	suvorexant
139	3A457	tacrolimus(fk506)
140	3A457	tamoxifen
141	3A457	tasimelteon
142	3A457	taxol
143	3A457	telaprevir
144	3A457	telithromycin
145	3A457	terfenadine
146	3A457	testosterone
147	3A457	ticagrelor
148	3A457	tofacitinib
149	3A457	tolvaptan
150	3A457	torisel
151	3A457	tramadol
152	3A457	trazodone
153	3A457	valbenazine
154	3A457	vandetanib
155	3A457	velpatasvir
156	3A457	vemurafenib
157	3A457	venetoclax
158	3A457	venlafaxine
159	3A457	verapamil
160	3A457	vilazodone
161	3A457	vincristine
162	3A457	vorapaxar
163	3A457	voriconazole
164	3A457	zaleplon
165	3A457	ziprasidone
166	3A457	zolpidem

will decrease lesinurad effect

#

enzyme

inducers

lesinurad will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.