The following drugs will decrease ribociclib effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	3A457	carbamazepine
3	3A457	clobazam
4	3A457	dabrafenib
5	3A457	efavirenz
6	3A457	elagolix
7	3A457	enzalutamide
8	3A457	eslicarbazepine
9	3A457	glucocorticoids
10	3A457	letermovir
11	3A457	lorlatinib
12	3A457	modafinil
13	3A457	nevirapine
14	3A457	oxcarbazepine
15	3A457	perampanel
16	3A457	phenobarbital
17	3A457	phenytoin
18	3A457	pioglitazone
19	3A457	rifabutin
20	3A457	rifampin
21	3A457	St. John's Wort
22	3A457	telotristat
23	3A457	troglitazone
24	3A457	vemurafenib

the follwing drugs will Increase ribociclib effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	3A457	atomoxetine
3	3A457	boceprevir	under review
4	3A457	ceritinib	Strong inhibitor
5	3A457	chloramphenicol	In-Vitro Only
6	3A457	cimetidine
7	3A457	ciprofloxacin	under review
8	3A457	clarithromycin	Strong inhibitor
9	3A457	crizotinib	Moderate inhibitor
10	3A457	delaviridine	under review
11	3A457	diethyl-dithiocarbamate
12	3A457	diltiazem	Moderate inhibitor
13	3A457	entrectinib
14	3A457	erythromycin	Moderate inhibitor
15	3A457	esomeprazole
16	3A457	fluconazole	Moderate inhibitor
17	3A457	fluvoxamine	under review
18	3A457	gestodene	under review
19	3A457	grapefruit juice	Moderate inhibitor
20	3A457	idelalisib	Strong inhibitor
21	3A457	imatinib	under review
22	3A457	indinavir	Strong inhibitor
23	3A457	itraconazole	Strong inhibitor
24	3A457	ivacaftor
25	3A457	ketoconazole	Strong inhibitor
26	3A457	lesinurad
27	3A457	letermovir
28	3A457	mibefradil	Strong inhibitor
29	3A457	mifepristone	under review
30	3A457	nefazodone	Strong inhibitor
31	3A457	nelfinavir	Strong inhibitor
32	3A457	netupitant/palonosetron	Moderate inhibitor
33	3A457	norfloxacin	under review
34	3A457	norfluoxetine	under review
35	3A457	omeprazole	Weak inhibitor
36	3A457	pantoprazole
37	3A457	perampanel
38	3A457	quercetin
39	3A457	regorafenib	under review
40	3A457	ribociclib	Strong inhibitor
41	3A457	ritonavir	Strong inhibitor
42	3A457	rucaparib
43	3A457	saquinavir	Strong inhibitor
44	3A457	simeprevir
45	3A457	starfruit	under review
46	3A457	telaprevir	under review
47	3A457	telithromycin	Strong inhibitor
48	3A457	ticagrelor
49	3A457	tucatinib	Strong inhibitor
50	3A457	verapamil	Moderate inhibitor
51	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by ribociclib effect

#	enzyme	drug	level
1	3A457	abemaciclib	Strong inhibitor
2	3A457	abiraterone	Strong inhibitor
3	3A457	acalabrutinib	Strong inhibitor
4	1A2	acetaminophen	Weak inhibitor
5	3A457	alectinib	Strong inhibitor
6	3A457	alfentanil	Strong inhibitor
7	3A457	alprazolam	Strong inhibitor
8	3A457	amitriptyline	Strong inhibitor
9	1A2	amitriptyline	Weak inhibitor
10	3A457	amlodipine	Strong inhibitor
11	3A457	apixaban	Strong inhibitor
12	1A2	apremilast	Weak inhibitor
13	3A457	aprepitant	Strong inhibitor
14	3A457	aripiprazole	Strong inhibitor
15	3A457	astemizole	Strong inhibitor
16	3A457	atorvastatin	Strong inhibitor
17	3A457	avanafil	Strong inhibitor
18	3A457	axitinib	Strong inhibitor
19	3A457	boceprevir	Strong inhibitor
20	3A457	bosutinib	Strong inhibitor
21	3A457	brexpiprazole	Strong inhibitor
22	3A457	brigatinib	Strong inhibitor
23	3A457	buspirone	Strong inhibitor
24	3A457	cafergot	Strong inhibitor
25	3A457	caffeine	Strong inhibitor
26	1A2	caffeine	Weak inhibitor
27	3A457	carbamazepine	Strong inhibitor
28	3A457	cariprazine	Strong inhibitor
29	3A457	ceritinib	Strong inhibitor
30	3A457	cerivastatin	Strong inhibitor
31	3A457	chlorpheniramine	Strong inhibitor
32	3A457	cilostazol	Strong inhibitor
33	3A457	cisapride	Strong inhibitor
34	3A457	citalopram	Strong inhibitor
35	3A457	clarithromycin	Strong inhibitor
36	3A457	clobazam	Strong inhibitor
37	1A2	clomipramine	Weak inhibitor
38	3A457	clopidogrel	Strong inhibitor
39	1A2	clozapine	Weak inhibitor
40	3A457	cobimetinib	Strong inhibitor
41	3A457	cocaine	Strong inhibitor
42	3A457	codeine	Strong inhibitor
43	3A457	colchicine	Strong inhibitor
44	3A457	copanlisib	Strong inhibitor
45	3A457	crizotinib	Strong inhibitor
46	1A2	cyclobenzaprine	Weak inhibitor
47	3A457	cyclosporine	Strong inhibitor
48	3A457	dabrafenib	Strong inhibitor
49	3A457	daclatasvir	Strong inhibitor
50	3A457	dapsone	Strong inhibitor
51	3A457	deflazacort	Strong inhibitor
52	3A457	dexamethasone	Strong inhibitor
53	3A457	dextromethorphan	Strong inhibitor
54	3A457	diazepam	Strong inhibitor
55	3A457	diltiazem	Strong inhibitor
56	3A457	docetaxel	Strong inhibitor
57	3A457	dolutegravir	Strong inhibitor
58	3A457	domperidone	Strong inhibitor
59	3A457	doxepin	Strong inhibitor
60	1A2	doxepin	Weak inhibitor
61	1A2	duloxetine	Weak inhibitor
62	3A457	elagolix	Strong inhibitor
63	3A457	elbasvir/grazoprevir	Strong inhibitor
64	3A457	eliglustat	Strong inhibitor
65	3A457	enzalutamide	Strong inhibitor
66	3A457	eplerenone	Strong inhibitor
67	3A457	erythromycin2	Strong inhibitor
68	3A457	escitalopram	Strong inhibitor
69	3A457	esomeprazole	Strong inhibitor
70	3A457	estradiol	Strong inhibitor
71	1A2	estradiol	Weak inhibitor
72	3A457	felodipine	Strong inhibitor
73	3A457	fentanyl	Strong inhibitor
74	3A457	finasteride	Strong inhibitor
75	3A457	flibanserin	Strong inhibitor
76	1A2	fluvoxamine	Weak inhibitor
77	3A457	gleevec	Strong inhibitor
78	3A457	haloperidol	Strong inhibitor
79	1A2	haloperidol	Weak inhibitor
80	3A457	hydrocortisone	Strong inhibitor
81	3A457	ibrutinib	Strong inhibitor
82	3A457	idelalisib	Strong inhibitor
83	1A2	imipramine	Weak inhibitor
84	3A457	indacaterol	Strong inhibitor
85	3A457	indinavir	Strong inhibitor
86	3A457	irinotecan	Strong inhibitor
87	3A457	isavuconazonium	Strong inhibitor
88	3A457	ivabradine	Strong inhibitor
89	3A457	ivacaftor	Strong inhibitor
90	3A457	LAAM	Strong inhibitor
91	3A457	lansoprazole	Strong inhibitor
92	3A457	lenvatinib	Strong inhibitor
93	3A457	lercanidipine	Strong inhibitor
94	3A457	lidocaine	Strong inhibitor
95	3A457	linagliptin	Strong inhibitor
96	3A457	lovastatin	Strong inhibitor
97	3A457	macitentan	Strong inhibitor
98	3A457	mavacamten	Strong inhibitor
99	3A457	methadone	Strong inhibitor
100	1A2	mexiletine	Weak inhibitor
101	3A457	midazolam	Strong inhibitor
102	1A2	nabumetone	Weak inhibitor
103	3A457	naldemedine	Strong inhibitor
104	3A457	naloxegol	Strong inhibitor
105	1A2	naproxen	Weak inhibitor
106	3A457	nateglinide	Strong inhibitor
107	3A457	nelfinavir	Strong inhibitor
108	3A457	neratinib	Strong inhibitor
109	3A457	netupitant/palonosetron	Strong inhibitor
110	3A457	nevirapine	Strong inhibitor
111	3A457	nifedipine	Strong inhibitor
112	3A457	nirmatrelvir	Strong inhibitor
113	3A457	nisoldipine	Strong inhibitor
114	3A457	nitrendipine	Strong inhibitor
115	1A2	olanzapine	Weak inhibitor
116	3A457	olaparib	Strong inhibitor
117	3A457	omeprazole	Strong inhibitor
118	3A457	ondansetron	Strong inhibitor
119	1A2	ondansetron	Weak inhibitor
120	3A457	osimertinib	Strong inhibitor
121	3A457	ospemifene	Strong inhibitor
122	3A457	palbociclib	Strong inhibitor
123	3A457	panobinostat	Strong inhibitor
124	3A457	pantoprazole	Strong inhibitor
125	3A457	perampanel	Strong inhibitor
126	1A2	phenacetin	Weak inhibitor
127	3A457	pimavanserin	Strong inhibitor
128	3A457	pimozide	Strong inhibitor
129	1A2	pirfenidone	Weak inhibitor
130	3A457	pomalidomide	Strong inhibitor
131	1A2	pomalidomide	Weak inhibitor
132	3A457	ponatinib	Strong inhibitor
133	3A457	progesterone	Strong inhibitor
134	3A457	propranolol	Strong inhibitor
135	1A2	propranolol	Weak inhibitor
136	3A457	quetiapine	Strong inhibitor
137	3A457	quinidine	Strong inhibitor
138	3A457	quinine	Strong inhibitor
139	3A457	regorafenib	Strong inhibitor
140	3A457	ribociclib	Strong inhibitor
141	3A457	rilpivirine	Strong inhibitor
142	1A2	riluzole	Weak inhibitor
143	3A457	risperidone	Strong inhibitor
144	3A457	ritonavir	Strong inhibitor
145	3A457	rivaroxaban	Strong inhibitor
146	3A457	roflumilast	Strong inhibitor
147	1A2	roflumilast	Weak inhibitor
148	3A457	rolapitant	Strong inhibitor
149	3A457	romidepsin	Strong inhibitor
150	1A2	ropivacaine	Weak inhibitor
151	3A457	rucaparib	Strong inhibitor
152	1A2	rucaparib	Weak inhibitor
153	3A457	ruxolitinib	Strong inhibitor
154	3A457	salmeterol	Strong inhibitor
155	3A457	saquinavir	Strong inhibitor
156	3A457	selexipag	Strong inhibitor
157	3A457	sildenafil	Strong inhibitor
158	3A457	simeprevir	Strong inhibitor
159	3A457	simvastatin	Strong inhibitor
160	3A457	sirolimus	Strong inhibitor
161	3A457	sonidegib	Strong inhibitor
162	3A457	sorafenib	Strong inhibitor
163	3A457	sunitinib	Strong inhibitor
164	3A457	suvorexant	Strong inhibitor
165	1A2	tacrine	Weak inhibitor
166	3A457	tacrolimus(fk506)	Strong inhibitor
167	3A457	tamoxifen	Strong inhibitor
168	3A457	tasimelteon	Strong inhibitor
169	1A2	tasimelteon	Weak inhibitor
170	3A457	taxol	Strong inhibitor
171	3A457	telaprevir	Strong inhibitor
172	3A457	telithromycin	Strong inhibitor
173	3A457	terfenadine	Strong inhibitor
174	3A457	testosterone	Strong inhibitor
175	1A2	theophylline	Weak inhibitor
176	3A457	ticagrelor	Strong inhibitor
177	1A2	tizanidine	Weak inhibitor
178	3A457	tofacitinib	Strong inhibitor
179	3A457	tolvaptan	Strong inhibitor
180	3A457	torisel	Strong inhibitor
181	3A457	tramadol	Strong inhibitor
182	3A457	trazodone	Strong inhibitor
183	1A2	triamterene	Weak inhibitor
184	3A457	valbenazine	Strong inhibitor
185	3A457	vandetanib	Strong inhibitor
186	3A457	velpatasvir	Strong inhibitor
187	3A457	vemurafenib	Strong inhibitor
188	3A457	venetoclax	Strong inhibitor
189	3A457	venlafaxine	Strong inhibitor
190	3A457	verapamil	Strong inhibitor
191	1A2	verapamil	Weak inhibitor
192	3A457	vilazodone	Strong inhibitor
193	3A457	vincristine	Strong inhibitor
194	3A457	vorapaxar	Strong inhibitor
195	3A457	voriconazole	Strong inhibitor
196	1A2	warfarin	Weak inhibitor
197	3A457	zaleplon	Strong inhibitor
198	1A2	zileuton	Weak inhibitor
199	3A457	ziprasidone	Strong inhibitor
200	1A2	zolmitriptan	Weak inhibitor
201	3A457	zolpidem	Strong inhibitor

will decrease ribociclib effect

#

enzyme

inducers

ribociclib will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.