chloramphenicol
The following drugs will decrease chloramphenicol effect
| # | enzyme | inducers |
| 0 | 2C19 | carbamazepine |
| 1 | 2C19 | enzalutamide |
| 2 | 2C19 | letermovir |
| 3 | 2C19 | norethindrone |
| 4 | 2C19 | prednisone |
| 5 | 2C19 | rifampicin |
| 6 | 2C19 | ritonavir |
| 7 | 2C19 | efavirenz |
the follwing drugs will
Increase chloramphenicol effect
| # | enzyme | Inhibitors | level |
| 0 | 2C19 | armodafinil | Weak inhibitor |
| 1 | 2C19 | cimetidine | Weak inhibitor |
| 2 | 2C19 | citalopram | Weak inhibitor |
| 3 | 2C19 | esomeprazole | Weak inhibitor |
| 4 | 2C19 | felbamate | Weak inhibitor |
| 5 | 2C19 | fluconazole | Moderate inhibitor |
| 6 | 2C19 | fluoxetine | Moderate inhibitor |
| 7 | 2C19 | fluvoxamine | Strong inhibitor |
| 8 | 2C19 | isoniazid | Weak inhibitor |
| 9 | 2C19 | ketoconazole | Moderate inhibitor |
| 10 | 2C19 | luliconazole | Weak inhibitor |
| 11 | 2C19 | modafinil | Weak inhibitor |
| 12 | 2C19 | omeprazole | Weak inhibitor |
| 13 | 2C19 | oral contraceptives | Weak inhibitor |
| 14 | 2C19 | oritavancin | In-Vitro Only |
| 15 | 2C19 | pantoprazole | Weak inhibitor |
| 16 | 2C19 | quercetin | In-Vitro Only |
| 17 | 2C19 | ticlopidine | Strong inhibitor |
| 18 | 2C19 | topiramate | under review |
| 19 | 2C19 | voriconazole | Moderate inhibitor |
The follwing drugs will Increase effect by chloramphenicol effect
| # | enzyme | drug | level |
| 1 | 3A457 | abemaciclib | In-Vitro Only |
| 2 | 3A457 | abiraterone | In-Vitro Only |
| 3 | 3A457 | acalabrutinib | In-Vitro Only |
| 4 | 3A457 | alectinib | In-Vitro Only |
| 5 | 3A457 | alfentanil | In-Vitro Only |
| 6 | 3A457 | alprazolam | In-Vitro Only |
| 7 | 2C19 | amitriptyline | In-Vitro Only |
| 8 | 3A457 | amitriptyline | In-Vitro Only |
| 9 | 3A457 | amlodipine | In-Vitro Only |
| 10 | 3A457 | apixaban | In-Vitro Only |
| 11 | 3A457 | aprepitant | In-Vitro Only |
| 12 | 3A457 | aripiprazole | In-Vitro Only |
| 13 | 3A457 | astemizole | In-Vitro Only |
| 14 | 2C19 | atomoxetine | In-Vitro Only |
| 15 | 3A457 | atorvastatin | In-Vitro Only |
| 16 | 3A457 | avanafil | In-Vitro Only |
| 17 | 3A457 | axitinib | In-Vitro Only |
| 18 | 3A457 | boceprevir | In-Vitro Only |
| 19 | 3A457 | bosutinib | In-Vitro Only |
| 20 | 3A457 | brexpiprazole | In-Vitro Only |
| 21 | 3A457 | brigatinib | In-Vitro Only |
| 22 | 2C19 | brivaracetam | In-Vitro Only |
| 23 | 3A457 | buspirone | In-Vitro Only |
| 24 | 3A457 | cafergot | In-Vitro Only |
| 25 | 3A457 | caffeine | In-Vitro Only |
| 26 | 3A457 | carbamazepine | In-Vitro Only |
| 27 | 3A457 | cariprazine | In-Vitro Only |
| 28 | 2C19 | carisoprodol | In-Vitro Only |
| 29 | 2C19 | celecoxib | In-Vitro Only |
| 30 | 3A457 | ceritinib | In-Vitro Only |
| 31 | 3A457 | cerivastatin | In-Vitro Only |
| 32 | 3A457 | chlorpheniramine | In-Vitro Only |
| 33 | 3A457 | cilostazol | In-Vitro Only |
| 34 | 3A457 | cisapride | In-Vitro Only |
| 35 | 2C19 | citalopram | In-Vitro Only |
| 36 | 3A457 | citalopram | In-Vitro Only |
| 37 | 3A457 | clarithromycin | In-Vitro Only |
| 38 | 2C19 | clobazam | In-Vitro Only |
| 39 | 3A457 | clobazam | In-Vitro Only |
| 40 | 2C19 | clomipramine | In-Vitro Only |
| 41 | 2C19 | clopidogrel | In-Vitro Only |
| 42 | 3A457 | clopidogrel | In-Vitro Only |
| 43 | 3A457 | cobimetinib | In-Vitro Only |
| 44 | 3A457 | cocaine | In-Vitro Only |
| 45 | 3A457 | codeine | In-Vitro Only |
| 46 | 3A457 | colchicine | In-Vitro Only |
| 47 | 3A457 | copanlisib | In-Vitro Only |
| 48 | 3A457 | crizotinib | In-Vitro Only |
| 49 | 2C19 | cyclophosphamide | In-Vitro Only |
| 50 | 3A457 | cyclosporine | In-Vitro Only |
| 51 | 3A457 | dabrafenib | In-Vitro Only |
| 52 | 3A457 | daclatasvir | In-Vitro Only |
| 53 | 3A457 | dapsone | In-Vitro Only |
| 54 | 3A457 | deflazacort | In-Vitro Only |
| 55 | 3A457 | dexamethasone | In-Vitro Only |
| 56 | 3A457 | dextromethorphan | In-Vitro Only |
| 57 | 2C19 | diazepam | In-Vitro Only |
| 58 | 3A457 | diazepam | In-Vitro Only |
| 59 | 3A457 | diltiazem | In-Vitro Only |
| 60 | 3A457 | docetaxel | In-Vitro Only |
| 61 | 3A457 | dolutegravir | In-Vitro Only |
| 62 | 3A457 | domperidone | In-Vitro Only |
| 63 | 2C19 | doxepin | In-Vitro Only |
| 64 | 3A457 | doxepin | In-Vitro Only |
| 65 | 3A457 | elagolix | In-Vitro Only |
| 66 | 3A457 | elbasvir/grazoprevir | In-Vitro Only |
| 67 | 3A457 | eliglustat | In-Vitro Only |
| 68 | 3A457 | enzalutamide | In-Vitro Only |
| 69 | 3A457 | eplerenone | In-Vitro Only |
| 70 | 3A457 | erythromycin2 | In-Vitro Only |
| 71 | 2C19 | escitalopram | In-Vitro Only |
| 72 | 3A457 | escitalopram | In-Vitro Only |
| 73 | 2C19 | esomeprazole | In-Vitro Only |
| 74 | 3A457 | esomeprazole | In-Vitro Only |
| 75 | 3A457 | estradiol | In-Vitro Only |
| 76 | 3A457 | felodipine | In-Vitro Only |
| 77 | 3A457 | fentanyl | In-Vitro Only |
| 78 | 3A457 | finasteride | In-Vitro Only |
| 79 | 2C19 | flibanserin | In-Vitro Only |
| 80 | 3A457 | flibanserin | In-Vitro Only |
| 81 | 3A457 | gleevec | In-Vitro Only |
| 82 | 3A457 | haloperidol | In-Vitro Only |
| 83 | 2C19 | hexobarbital | In-Vitro Only |
| 84 | 3A457 | hydrocortisone | In-Vitro Only |
| 85 | 3A457 | ibrutinib | In-Vitro Only |
| 86 | 3A457 | idelalisib | In-Vitro Only |
| 87 | 2C19 | imipramine | In-Vitro Only |
| 88 | 3A457 | indacaterol | In-Vitro Only |
| 89 | 3A457 | indinavir | In-Vitro Only |
| 90 | 2C19 | indomethacin | In-Vitro Only |
| 91 | 3A457 | irinotecan | In-Vitro Only |
| 92 | 3A457 | isavuconazonium | In-Vitro Only |
| 93 | 3A457 | ivabradine | In-Vitro Only |
| 94 | 3A457 | ivacaftor | In-Vitro Only |
| 95 | 3A457 | LAAM | In-Vitro Only |
| 96 | 2C19 | labetalol | In-Vitro Only |
| 97 | 2C19 | lansoprazole | In-Vitro Only |
| 98 | 3A457 | lansoprazole | In-Vitro Only |
| 99 | 3A457 | lenvatinib | In-Vitro Only |
| 100 | 3A457 | lercanidipine | In-Vitro Only |
| 101 | 3A457 | lidocaine | In-Vitro Only |
| 102 | 3A457 | linagliptin | In-Vitro Only |
| 103 | 3A457 | lovastatin | In-Vitro Only |
| 104 | 3A457 | macitentan | In-Vitro Only |
| 105 | 2C19 | mavacamten | In-Vitro Only |
| 106 | 3A457 | mavacamten | In-Vitro Only |
| 107 | 3A457 | methadone | In-Vitro Only |
| 108 | 3A457 | midazolam | In-Vitro Only |
| 109 | 2C19 | moclobemide | In-Vitro Only |
| 110 | 3A457 | naldemedine | In-Vitro Only |
| 111 | 3A457 | naloxegol | In-Vitro Only |
| 112 | 3A457 | nateglinide | In-Vitro Only |
| 113 | 2C19 | nelfinavir | In-Vitro Only |
| 114 | 3A457 | nelfinavir | In-Vitro Only |
| 115 | 3A457 | neratinib | In-Vitro Only |
| 116 | 3A457 | netupitant/palonosetron | In-Vitro Only |
| 117 | 3A457 | nevirapine | In-Vitro Only |
| 118 | 3A457 | nifedipine | In-Vitro Only |
| 119 | 2C19 | nilutamide | In-Vitro Only |
| 120 | 3A457 | nirmatrelvir | In-Vitro Only |
| 121 | 3A457 | nisoldipine | In-Vitro Only |
| 122 | 3A457 | nitrendipine | In-Vitro Only |
| 123 | 3A457 | olaparib | In-Vitro Only |
| 124 | 2C19 | omeprazole | In-Vitro Only |
| 125 | 3A457 | omeprazole | In-Vitro Only |
| 126 | 3A457 | ondansetron | In-Vitro Only |
| 127 | 3A457 | osimertinib | In-Vitro Only |
| 128 | 2C19 | ospemifene | In-Vitro Only |
| 129 | 3A457 | ospemifene | In-Vitro Only |
| 130 | 3A457 | palbociclib | In-Vitro Only |
| 131 | 3A457 | panobinostat | In-Vitro Only |
| 132 | 2C19 | pantoprazole | In-Vitro Only |
| 133 | 3A457 | pantoprazole | In-Vitro Only |
| 134 | 3A457 | perampanel | In-Vitro Only |
| 135 | 2C19 | phenobarbitone | In-Vitro Only |
| 136 | 2C19 | phenytoin | In-Vitro Only |
| 137 | 3A457 | pimavanserin | In-Vitro Only |
| 138 | 3A457 | pimozide | In-Vitro Only |
| 139 | 2C19 | pomalidomide | In-Vitro Only |
| 140 | 3A457 | pomalidomide | In-Vitro Only |
| 141 | 3A457 | ponatinib | In-Vitro Only |
| 142 | 2C19 | primidone | In-Vitro Only |
| 143 | 2C19 | progesterone | In-Vitro Only |
| 144 | 3A457 | progesterone | In-Vitro Only |
| 145 | 2C19 | proguanil | In-Vitro Only |
| 146 | 2C19 | propranolol | In-Vitro Only |
| 147 | 3A457 | propranolol | In-Vitro Only |
| 148 | 3A457 | quetiapine | In-Vitro Only |
| 149 | 3A457 | quinidine | In-Vitro Only |
| 150 | 3A457 | quinine | In-Vitro Only |
| 151 | 2C19 | r-mephobarbital | In-Vitro Only |
| 152 | 2C19 | r-warfarin | In-Vitro Only |
| 153 | 3A457 | regorafenib | In-Vitro Only |
| 154 | 3A457 | ribociclib | In-Vitro Only |
| 155 | 3A457 | rilpivirine | In-Vitro Only |
| 156 | 3A457 | risperidone | In-Vitro Only |
| 157 | 3A457 | ritonavir | In-Vitro Only |
| 158 | 3A457 | rivaroxaban | In-Vitro Only |
| 159 | 3A457 | roflumilast | In-Vitro Only |
| 160 | 3A457 | rolapitant | In-Vitro Only |
| 161 | 3A457 | romidepsin | In-Vitro Only |
| 162 | 3A457 | rucaparib | In-Vitro Only |
| 163 | 3A457 | ruxolitinib | In-Vitro Only |
| 164 | 2C19 | s-mephenytoin | In-Vitro Only |
| 165 | 3A457 | salmeterol | In-Vitro Only |
| 166 | 3A457 | saquinavir | In-Vitro Only |
| 167 | 3A457 | selexipag | In-Vitro Only |
| 168 | 3A457 | sildenafil | In-Vitro Only |
| 169 | 3A457 | simeprevir | In-Vitro Only |
| 170 | 3A457 | simvastatin | In-Vitro Only |
| 171 | 3A457 | sirolimus | In-Vitro Only |
| 172 | 3A457 | sonidegib | In-Vitro Only |
| 173 | 3A457 | sorafenib | In-Vitro Only |
| 174 | 3A457 | sunitinib | In-Vitro Only |
| 175 | 2C19 | suvorexant | In-Vitro Only |
| 176 | 3A457 | suvorexant | In-Vitro Only |
| 177 | 3A457 | tacrolimus(fk506) | In-Vitro Only |
| 178 | 3A457 | tamoxifen | In-Vitro Only |
| 179 | 3A457 | tasimelteon | In-Vitro Only |
| 180 | 3A457 | taxol | In-Vitro Only |
| 181 | 3A457 | telaprevir | In-Vitro Only |
| 182 | 3A457 | telithromycin | In-Vitro Only |
| 183 | 2C19 | teniposide | In-Vitro Only |
| 184 | 3A457 | terfenadine | In-Vitro Only |
| 185 | 3A457 | testosterone | In-Vitro Only |
| 186 | 3A457 | ticagrelor | In-Vitro Only |
| 187 | 2C19 | tofacitinib | In-Vitro Only |
| 188 | 3A457 | tofacitinib | In-Vitro Only |
| 189 | 3A457 | tolvaptan | In-Vitro Only |
| 190 | 3A457 | torisel | In-Vitro Only |
| 191 | 3A457 | tramadol | In-Vitro Only |
| 192 | 3A457 | trazodone | In-Vitro Only |
| 193 | 3A457 | valbenazine | In-Vitro Only |
| 194 | 3A457 | vandetanib | In-Vitro Only |
| 195 | 3A457 | velpatasvir | In-Vitro Only |
| 196 | 3A457 | vemurafenib | In-Vitro Only |
| 197 | 3A457 | venetoclax | In-Vitro Only |
| 198 | 2C19 | venlafaxine | In-Vitro Only |
| 199 | 3A457 | venlafaxine | In-Vitro Only |
| 200 | 3A457 | verapamil | In-Vitro Only |
| 201 | 2C19 | vilazodone | In-Vitro Only |
| 202 | 3A457 | vilazodone | In-Vitro Only |
| 203 | 3A457 | vincristine | In-Vitro Only |
| 204 | 3A457 | vorapaxar | In-Vitro Only |
| 205 | 2C19 | voriconazole | In-Vitro Only |
| 206 | 3A457 | voriconazole | In-Vitro Only |
| 207 | 3A457 | zaleplon | In-Vitro Only |
| 208 | 3A457 | ziprasidone | In-Vitro Only |
| 209 | 3A457 | zolpidem | In-Vitro Only |
will
decrease chloramphenicol effect
chloramphenicol will not affect
Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.