The following drugs will decrease efavirenz effect

#	enzyme	inducers
0	2B6	artemisinin
1	2B6	carbamazepine
2	2B6	dabrafenib
3	2B6	efavirenz
4	2B6	letermovir
5	2B6	nevirapine
6	2B6	perampanel
7	2B6	phenobarbital
8	2B6	phenytoin
9	2B6	rifampin
10	2B6	roflumilast

the follwing drugs will Increase efavirenz effect

#	enzyme	Inhibitors	level
0	2B6	clopidogrel	Weak inhibitor
1	2B6	thiotepa	Weak inhibitor
2	2B6	ticlopidine	Strong inhibitor
3	2B6	voriconazole	Moderate inhibitor

The follwing drugs will Increase effect by efavirenz effect

#	enzyme	drug	level
1	1A2	acetaminophen	Weak inhibitor
2	1A2	amitriptyline	Weak inhibitor
3	2C9	amitriptyline	Weak inhibitor
4	1A2	apremilast	Weak inhibitor
5	2C9	azilsartan	Weak inhibitor
6	1A2	caffeine	Weak inhibitor
7	2C9	capecitabine	Weak inhibitor
8	2C9	celecoxib	Weak inhibitor
9	1A2	clomipramine	Weak inhibitor
10	2C9	clopidogrel	Weak inhibitor
11	1A2	clozapine	Weak inhibitor
12	1A2	cyclobenzaprine	Weak inhibitor
13	2C9	diclofenac	Weak inhibitor
14	1A2	doxepin	Weak inhibitor
15	2C9	doxepin	Weak inhibitor
16	1A2	duloxetine	Weak inhibitor
17	1A2	estradiol	Weak inhibitor
18	2C9	fluoxetine	Weak inhibitor
19	2C9	fluvastatin	Weak inhibitor
20	1A2	fluvoxamine	Weak inhibitor
21	2C9	glibenclamide	Weak inhibitor
22	2C9	glimepiride	Weak inhibitor
23	2C9	glipizide	Weak inhibitor
24	2C9	glyburide	Weak inhibitor
25	1A2	haloperidol	Weak inhibitor
26	2C9	ibuprofen	Weak inhibitor
27	1A2	imipramine	Weak inhibitor
28	2C9	irbesartan	Weak inhibitor
29	2C9	lesinurad	Weak inhibitor
30	2C9	lornoxicam	Weak inhibitor
31	2C9	losartan	Weak inhibitor
32	2C9	meloxicam	Weak inhibitor
33	1A2	mexiletine	Weak inhibitor
34	1A2	nabumetone	Weak inhibitor
35	1A2	naproxen	Weak inhibitor
36	2C9	nateglinide	Weak inhibitor
37	1A2	olanzapine	Weak inhibitor
38	2C9	olodaterol	Weak inhibitor
39	1A2	ondansetron	Weak inhibitor
40	2C9	ospemifene	Weak inhibitor
41	1A2	phenacetin	Weak inhibitor
42	2C9	phenytoin	Weak inhibitor
43	1A2	pirfenidone	Weak inhibitor
44	2C9	piroxicam	Weak inhibitor
45	1A2	pomalidomide	Weak inhibitor
46	1A2	propranolol	Weak inhibitor
47	1A2	riluzole	Weak inhibitor
48	1A2	roflumilast	Weak inhibitor
49	1A2	ropivacaine	Weak inhibitor
50	2C9	rosiglitazone	Weak inhibitor
51	1A2	rucaparib	Weak inhibitor
52	2C9	s-warfarin	Weak inhibitor
53	2C9	suprofen	Weak inhibitor
54	1A2	tacrine	Weak inhibitor
55	2C9	tamoxifen	Weak inhibitor
56	1A2	tasimelteon	Weak inhibitor
57	1A2	theophylline	Weak inhibitor
58	1A2	tizanidine	Weak inhibitor
59	2C9	tolbutamide	Weak inhibitor
60	2C9	torsemide	Weak inhibitor
61	1A2	triamterene	Weak inhibitor
62	2C9	valproic acid	Weak inhibitor
63	2C9	venlafaxine	Weak inhibitor
64	1A2	verapamil	Weak inhibitor
65	2C9	voriconazole	Weak inhibitor
66	1A2	warfarin	Weak inhibitor
67	2C9	zafirlukast	Weak inhibitor
68	1A2	zileuton	Weak inhibitor
69	1A2	zolmitriptan	Weak inhibitor

The following drugs will decreased effect by efavirenz effect

#	enzyme	drug
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	3A457	alectinib
5	3A457	alfentanil
6	3A457	alprazolam
7	2C19	amitriptyline
8	3A457	amitriptyline
9	3A457	amlodipine
10	3A457	apixaban
11	3A457	aprepitant
12	3A457	aripiprazole
13	2B6	artemisinin
14	3A457	astemizole
15	2C19	atomoxetine
16	3A457	atorvastatin
17	3A457	avanafil
18	3A457	axitinib
19	3A457	boceprevir
20	3A457	bosutinib
21	3A457	brexpiprazole
22	3A457	brigatinib
23	2C19	brivaracetam
24	2B6	bupropion
25	3A457	buspirone
26	3A457	cafergot
27	3A457	caffeine
28	3A457	carbamazepine
29	3A457	cariprazine
30	2C19	carisoprodol
31	2C19	celecoxib
32	3A457	ceritinib
33	3A457	cerivastatin
34	2C19	chloramphenicol
35	3A457	chlorpheniramine
36	3A457	cilostazol
37	3A457	cisapride
38	2C19	citalopram
39	3A457	citalopram
40	3A457	clarithromycin
41	2B6	clobazam
42	2C19	clobazam
43	3A457	clobazam
44	2C19	clomipramine
45	2C19	clopidogrel
46	3A457	clopidogrel
47	3A457	cobimetinib
48	3A457	cocaine
49	3A457	codeine
50	3A457	colchicine
51	3A457	copanlisib
52	3A457	crizotinib
53	2B6	cyclophosphamide
54	2C19	cyclophosphamide
55	3A457	cyclosporine
56	3A457	dabrafenib
57	3A457	daclatasvir
58	3A457	dapsone
59	3A457	deflazacort
60	3A457	dexamethasone
61	3A457	dextromethorphan
62	2C19	diazepam
63	3A457	diazepam
64	3A457	diltiazem
65	3A457	docetaxel
66	3A457	dolutegravir
67	3A457	domperidone
68	2C19	doxepin
69	3A457	doxepin
70	2B6	efavirenz
71	3A457	elagolix
72	3A457	elbasvir/grazoprevir
73	3A457	eliglustat
74	3A457	enzalutamide
75	3A457	eplerenone
76	3A457	erythromycin2
77	2C19	escitalopram
78	3A457	escitalopram
79	2C19	esomeprazole
80	3A457	esomeprazole
81	3A457	estradiol
82	3A457	felodipine
83	3A457	fentanyl
84	3A457	finasteride
85	2C19	flibanserin
86	3A457	flibanserin
87	3A457	gleevec
88	3A457	haloperidol
89	2C19	hexobarbital
90	3A457	hydrocortisone
91	3A457	ibrutinib
92	3A457	idelalisib
93	2B6	ifosphamide
94	2C19	imipramine
95	3A457	indacaterol
96	3A457	indinavir
97	2C19	indomethacin
98	3A457	irinotecan
99	3A457	isavuconazonium
100	3A457	ivabradine
101	3A457	ivacaftor
102	2B6	ketamine
103	3A457	LAAM
104	2C19	labetalol
105	2C19	lansoprazole
106	3A457	lansoprazole
107	3A457	lenvatinib
108	3A457	lercanidipine
109	3A457	lidocaine
110	3A457	linagliptin
111	3A457	lovastatin
112	3A457	macitentan
113	2C19	mavacamten
114	3A457	mavacamten
115	2B6	meperidine
116	2B6	methadone
117	3A457	methadone
118	3A457	midazolam
119	2C19	moclobemide
120	3A457	naldemedine
121	3A457	naloxegol
122	3A457	nateglinide
123	2C19	nelfinavir
124	3A457	nelfinavir
125	3A457	neratinib
126	3A457	netupitant/palonosetron
127	2B6	nevirapine
128	3A457	nevirapine
129	3A457	nifedipine
130	2C19	nilutamide
131	3A457	nirmatrelvir
132	3A457	nisoldipine
133	3A457	nitrendipine
134	3A457	olaparib
135	2C19	omeprazole
136	3A457	omeprazole
137	3A457	ondansetron
138	3A457	osimertinib
139	2C19	ospemifene
140	3A457	ospemifene
141	3A457	palbociclib
142	3A457	panobinostat
143	2C19	pantoprazole
144	3A457	pantoprazole
145	3A457	perampanel
146	2C19	phenobarbitone
147	2C19	phenytoin
148	3A457	pimavanserin
149	3A457	pimozide
150	2C19	pomalidomide
151	3A457	pomalidomide
152	3A457	ponatinib
153	2C19	primidone
154	2C19	progesterone
155	3A457	progesterone
156	2C19	proguanil
157	2B6	propafol
158	2C19	propranolol
159	3A457	propranolol
160	3A457	quetiapine
161	3A457	quinidine
162	3A457	quinine
163	2C19	r-mephobarbital
164	2C19	r-warfarin
165	3A457	regorafenib
166	3A457	ribociclib
167	3A457	rilpivirine
168	3A457	risperidone
169	3A457	ritonavir
170	3A457	rivaroxaban
171	3A457	roflumilast
172	3A457	rolapitant
173	3A457	romidepsin
174	3A457	rucaparib
175	3A457	ruxolitinib
176	2C19	s-mephenytoin
177	3A457	salmeterol
178	3A457	saquinavir
179	2B6	selegiline
180	3A457	selexipag
181	3A457	sildenafil
182	3A457	simeprevir
183	3A457	simvastatin
184	3A457	sirolimus
185	3A457	sonidegib
186	2B6	sorafenib
187	3A457	sorafenib
188	3A457	sunitinib
189	2C19	suvorexant
190	3A457	suvorexant
191	3A457	tacrolimus(fk506)
192	3A457	tamoxifen
193	3A457	tasimelteon
194	3A457	taxol
195	3A457	telaprevir
196	3A457	telithromycin
197	2C19	teniposide
198	3A457	terfenadine
199	3A457	testosterone
200	3A457	ticagrelor
201	2C19	tofacitinib
202	3A457	tofacitinib
203	3A457	tolvaptan
204	3A457	torisel
205	2B6	tramadol
206	3A457	tramadol
207	3A457	trazodone
208	3A457	valbenazine
209	3A457	vandetanib
210	2B6	velpatasvir
211	3A457	velpatasvir
212	3A457	vemurafenib
213	3A457	venetoclax
214	2C19	venlafaxine
215	3A457	venlafaxine
216	3A457	verapamil
217	2C19	vilazodone
218	3A457	vilazodone
219	3A457	vincristine
220	3A457	vorapaxar
221	2C19	voriconazole
222	3A457	voriconazole
223	3A457	zaleplon
224	3A457	ziprasidone
225	3A457	zolpidem

will decrease efavirenz effect

#

enzyme

inducers

efavirenz will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.