The following drugs will decrease ritonavir effect

#	enzyme	inducers
0	3A457	barbiturates
1	3A457	brigatinib
2	3A457	carbamazepine
3	3A457	clobazam
4	3A457	dabrafenib
5	3A457	efavirenz
6	3A457	elagolix
7	3A457	enzalutamide
8	3A457	eslicarbazepine
9	3A457	glucocorticoids
10	3A457	letermovir
11	3A457	lorlatinib
12	3A457	modafinil
13	3A457	nevirapine
14	3A457	oxcarbazepine
15	3A457	perampanel
16	3A457	phenobarbital
17	3A457	phenytoin
18	3A457	pioglitazone
19	3A457	rifabutin
20	3A457	rifampin
21	3A457	St. John's Wort
22	3A457	telotristat
23	3A457	troglitazone
24	3A457	vemurafenib

the follwing drugs will Increase ritonavir effect

#	enzyme	Inhibitors	level
0	3A457	amiodarone	under review
1	3A457	aprepitant	Moderate inhibitor
2	3A457	atomoxetine
3	3A457	boceprevir	under review
4	3A457	ceritinib	Strong inhibitor
5	3A457	chloramphenicol	In-Vitro Only
6	3A457	cimetidine
7	3A457	ciprofloxacin	under review
8	3A457	clarithromycin	Strong inhibitor
9	3A457	crizotinib	Moderate inhibitor
10	3A457	delaviridine	under review
11	3A457	diethyl-dithiocarbamate
12	3A457	diltiazem	Moderate inhibitor
13	3A457	entrectinib
14	3A457	erythromycin	Moderate inhibitor
15	3A457	esomeprazole
16	3A457	fluconazole	Moderate inhibitor
17	3A457	fluvoxamine	under review
18	3A457	gestodene	under review
19	3A457	grapefruit juice	Moderate inhibitor
20	3A457	idelalisib	Strong inhibitor
21	3A457	imatinib	under review
22	3A457	indinavir	Strong inhibitor
23	3A457	itraconazole	Strong inhibitor
24	3A457	ivacaftor
25	3A457	ketoconazole	Strong inhibitor
26	3A457	lesinurad
27	3A457	letermovir
28	3A457	mibefradil	Strong inhibitor
29	3A457	mifepristone	under review
30	3A457	nefazodone	Strong inhibitor
31	3A457	nelfinavir	Strong inhibitor
32	3A457	netupitant/palonosetron	Moderate inhibitor
33	3A457	norfloxacin	under review
34	3A457	norfluoxetine	under review
35	3A457	omeprazole	Weak inhibitor
36	3A457	pantoprazole
37	3A457	perampanel
38	3A457	quercetin
39	3A457	regorafenib	under review
40	3A457	ribociclib	Strong inhibitor
41	3A457	ritonavir	Strong inhibitor
42	3A457	rucaparib
43	3A457	saquinavir	Strong inhibitor
44	3A457	simeprevir
45	3A457	starfruit	under review
46	3A457	telaprevir	under review
47	3A457	telithromycin	Strong inhibitor
48	3A457	ticagrelor
49	3A457	tucatinib	Strong inhibitor
50	3A457	verapamil	Moderate inhibitor
51	3A457	voriconazole	Strong inhibitor

The follwing drugs will Increase effect by ritonavir effect

#	enzyme	drug	level
1	3A457	abemaciclib	Strong inhibitor
2	3A457	abiraterone	Strong inhibitor
3	3A457	acalabrutinib	Strong inhibitor
4	3A457	alectinib	Strong inhibitor
5	3A457	alfentanil	Strong inhibitor
6	3A457	alprazolam	Strong inhibitor
7	2D6	alprenolol
8	2D6	amitriptyline
9	3A457	amitriptyline	Strong inhibitor
10	3A457	amlodipine	Strong inhibitor
11	2D6	amphetamine
12	3A457	apixaban	Strong inhibitor
13	3A457	aprepitant	Strong inhibitor
14	3A457	aripiprazole	Strong inhibitor
15	3A457	astemizole	Strong inhibitor
16	2D6	atomoxetine
17	3A457	atorvastatin	Strong inhibitor
18	3A457	avanafil	Strong inhibitor
19	3A457	axitinib	Strong inhibitor
20	3A457	boceprevir	Strong inhibitor
21	3A457	bosutinib	Strong inhibitor
22	2D6	brexpiprazole
23	3A457	brexpiprazole	Strong inhibitor
24	3A457	brigatinib	Strong inhibitor
25	2D6	bufuralol
26	3A457	buspirone	Strong inhibitor
27	3A457	cafergot	Strong inhibitor
28	3A457	caffeine	Strong inhibitor
29	3A457	carbamazepine	Strong inhibitor
30	2D6	cariprazine
31	3A457	cariprazine	Strong inhibitor
32	2D6	carvedilol
33	3A457	ceritinib	Strong inhibitor
34	3A457	cerivastatin	Strong inhibitor
35	2D6	chlorpheniramine
36	3A457	chlorpheniramine	Strong inhibitor
37	2D6	chlorpromazine
38	3A457	cilostazol	Strong inhibitor
39	3A457	cisapride	Strong inhibitor
40	2D6	citalopram
41	3A457	citalopram	Strong inhibitor
42	3A457	clarithromycin	Strong inhibitor
43	3A457	clobazam	Strong inhibitor
44	2D6	clomipramine
45	2D6	clonidine
46	3A457	clopidogrel	Strong inhibitor
47	3A457	cobimetinib	Strong inhibitor
48	3A457	cocaine	Strong inhibitor
49	2D6	codeine
50	3A457	codeine	Strong inhibitor
51	3A457	colchicine	Strong inhibitor
52	3A457	copanlisib	Strong inhibitor
53	3A457	crizotinib	Strong inhibitor
54	3A457	cyclosporine	Strong inhibitor
55	3A457	dabrafenib	Strong inhibitor
56	3A457	daclatasvir	Strong inhibitor
57	3A457	dapsone	Strong inhibitor
58	2D6	debrisoquine
59	3A457	deflazacort	Strong inhibitor
60	2D6	desipramine
61	2D6	deutetrabenazine
62	3A457	dexamethasone	Strong inhibitor
63	2D6	dexfenfluramine
64	2D6	dextromethorphan
65	3A457	dextromethorphan	Strong inhibitor
66	3A457	diazepam	Strong inhibitor
67	3A457	diltiazem	Strong inhibitor
68	3A457	docetaxel	Strong inhibitor
69	3A457	dolutegravir	Strong inhibitor
70	3A457	domperidone	Strong inhibitor
71	2D6	donepezil
72	2D6	doxepin
73	3A457	doxepin	Strong inhibitor
74	3A457	elagolix	Strong inhibitor
75	3A457	elbasvir/grazoprevir	Strong inhibitor
76	2D6	eliglustat
77	3A457	eliglustat	Strong inhibitor
78	2D6	encainide
79	3A457	enzalutamide	Strong inhibitor
80	3A457	eplerenone	Strong inhibitor
81	3A457	erythromycin2	Strong inhibitor
82	2D6	escitalopram
83	3A457	escitalopram	Strong inhibitor
84	3A457	esomeprazole	Strong inhibitor
85	3A457	estradiol	Strong inhibitor
86	3A457	felodipine	Strong inhibitor
87	3A457	fentanyl	Strong inhibitor
88	3A457	finasteride	Strong inhibitor
89	2D6	flecainide
90	3A457	flibanserin	Strong inhibitor
91	2D6	fluoxetine
92	2D6	fluvoxamine
93	3A457	gleevec	Strong inhibitor
94	3A457	haloperidol	Strong inhibitor
95	3A457	hydrocortisone	Strong inhibitor
96	2D6	ibrutinib
97	3A457	ibrutinib	Strong inhibitor
98	3A457	idelalisib	Strong inhibitor
99	2D6	imipramine
100	3A457	indacaterol	Strong inhibitor
101	3A457	indinavir	Strong inhibitor
102	3A457	irinotecan	Strong inhibitor
103	3A457	isavuconazonium	Strong inhibitor
104	3A457	ivabradine	Strong inhibitor
105	3A457	ivacaftor	Strong inhibitor
106	3A457	LAAM	Strong inhibitor
107	3A457	lansoprazole	Strong inhibitor
108	3A457	lenvatinib	Strong inhibitor
109	3A457	lercanidipine	Strong inhibitor
110	2D6	lidocaine
111	3A457	lidocaine	Strong inhibitor
112	3A457	linagliptin	Strong inhibitor
113	3A457	lovastatin	Strong inhibitor
114	3A457	macitentan	Strong inhibitor
115	3A457	mavacamten	Strong inhibitor
116	3A457	methadone	Strong inhibitor
117	2D6	metoclopramide
118	2D6	metoprolol
119	2D6	mexiletine
120	3A457	midazolam	Strong inhibitor
121	2D6	minaprine
122	3A457	naldemedine	Strong inhibitor
123	3A457	naloxegol	Strong inhibitor
124	3A457	nateglinide	Strong inhibitor
125	2D6	nebivolol
126	3A457	nelfinavir	Strong inhibitor
127	3A457	neratinib	Strong inhibitor
128	3A457	netupitant/palonosetron	Strong inhibitor
129	3A457	nevirapine	Strong inhibitor
130	3A457	nifedipine	Strong inhibitor
131	3A457	nirmatrelvir	Strong inhibitor
132	3A457	nisoldipine	Strong inhibitor
133	3A457	nitrendipine	Strong inhibitor
134	2D6	nortriptyline
135	3A457	olaparib	Strong inhibitor
136	3A457	omeprazole	Strong inhibitor
137	2D6	ondansetron
138	3A457	ondansetron	Strong inhibitor
139	3A457	osimertinib	Strong inhibitor
140	3A457	ospemifene	Strong inhibitor
141	2D6	oxycodone
142	3A457	palbociclib	Strong inhibitor
143	3A457	panobinostat	Strong inhibitor
144	3A457	pantoprazole	Strong inhibitor
145	2D6	paroxetine
146	3A457	perampanel	Strong inhibitor
147	2D6	perhexiline
148	2D6	perphenazine
149	2D6	phenacetin
150	2D6	pimavanserin
151	3A457	pimavanserin	Strong inhibitor
152	3A457	pimozide	Strong inhibitor
153	3A457	pomalidomide	Strong inhibitor
154	2D6	ponatinib
155	3A457	ponatinib	Strong inhibitor
156	3A457	progesterone	Strong inhibitor
157	2D6	promethazine
158	2D6	propafenone
159	2D6	propranolol
160	3A457	propranolol	Strong inhibitor
161	3A457	quetiapine	Strong inhibitor
162	3A457	quinidine	Strong inhibitor
163	3A457	quinine	Strong inhibitor
164	3A457	regorafenib	Strong inhibitor
165	3A457	ribociclib	Strong inhibitor
166	3A457	rilpivirine	Strong inhibitor
167	2D6	risperidone
168	3A457	risperidone	Strong inhibitor
169	3A457	ritonavir	Strong inhibitor
170	3A457	rivaroxaban	Strong inhibitor
171	3A457	roflumilast	Strong inhibitor
172	3A457	rolapitant	Strong inhibitor
173	3A457	romidepsin	Strong inhibitor
174	2D6	rucaparib
175	3A457	rucaparib	Strong inhibitor
176	3A457	ruxolitinib	Strong inhibitor
177	3A457	salmeterol	Strong inhibitor
178	3A457	saquinavir	Strong inhibitor
179	3A457	selexipag	Strong inhibitor
180	3A457	sildenafil	Strong inhibitor
181	3A457	simeprevir	Strong inhibitor
182	3A457	simvastatin	Strong inhibitor
183	3A457	sirolimus	Strong inhibitor
184	3A457	sonidegib	Strong inhibitor
185	3A457	sorafenib	Strong inhibitor
186	2D6	sparteine
187	3A457	sunitinib	Strong inhibitor
188	3A457	suvorexant	Strong inhibitor
189	3A457	tacrolimus(fk506)	Strong inhibitor
190	2D6	tamoxifen
191	3A457	tamoxifen	Strong inhibitor
192	3A457	tasimelteon	Strong inhibitor
193	3A457	taxol	Strong inhibitor
194	3A457	telaprevir	Strong inhibitor
195	3A457	telithromycin	Strong inhibitor
196	3A457	terfenadine	Strong inhibitor
197	3A457	testosterone	Strong inhibitor
198	2D6	tetrabenzine
199	2D6	thioridazine
200	3A457	ticagrelor	Strong inhibitor
201	2D6	timolol
202	3A457	tofacitinib	Strong inhibitor
203	3A457	tolvaptan	Strong inhibitor
204	3A457	torisel	Strong inhibitor
205	2D6	tramadol
206	3A457	tramadol	Strong inhibitor
207	3A457	trazodone	Strong inhibitor
208	2D6	umeclidinium
209	2D6	valbenazine
210	3A457	valbenazine	Strong inhibitor
211	3A457	vandetanib	Strong inhibitor
212	3A457	velpatasvir	Strong inhibitor
213	3A457	vemurafenib	Strong inhibitor
214	3A457	venetoclax	Strong inhibitor
215	2D6	venlafaxine
216	3A457	venlafaxine	Strong inhibitor
217	3A457	verapamil	Strong inhibitor
218	2D6	vilazodone
219	3A457	vilazodone	Strong inhibitor
220	3A457	vincristine	Strong inhibitor
221	3A457	vorapaxar	Strong inhibitor
222	3A457	voriconazole	Strong inhibitor
223	3A457	zaleplon	Strong inhibitor
224	3A457	ziprasidone	Strong inhibitor
225	3A457	zolpidem	Strong inhibitor
226	2D6	zuclopenthixol

The following drugs will decreased effect by ritonavir effect

#	enzyme	drug
1	2C19	amitriptyline
2	2C19	atomoxetine
3	2C19	brivaracetam
4	2C19	carisoprodol
5	2C19	celecoxib
6	2C19	chloramphenicol
7	2C19	citalopram
8	2C19	clobazam
9	2C19	clomipramine
10	2C19	clopidogrel
11	2C19	cyclophosphamide
12	2C19	diazepam
13	2C19	doxepin
14	2C19	escitalopram
15	2C19	esomeprazole
16	2C19	flibanserin
17	2C19	hexobarbital
18	2C19	imipramine
19	2C19	indomethacin
20	2C19	labetalol
21	2C19	lansoprazole
22	2C19	mavacamten
23	2C19	moclobemide
24	2C19	nelfinavir
25	2C19	nilutamide
26	2C19	omeprazole
27	2C19	ospemifene
28	2C19	pantoprazole
29	2C19	phenobarbitone
30	2C19	phenytoin
31	2C19	pomalidomide
32	2C19	primidone
33	2C19	progesterone
34	2C19	proguanil
35	2C19	propranolol
36	2C19	r-mephobarbital
37	2C19	r-warfarin
38	2C19	s-mephenytoin
39	2C19	suvorexant
40	2C19	teniposide
41	2C19	tofacitinib
42	2C19	venlafaxine
43	2C19	vilazodone
44	2C19	voriconazole

will decrease ritonavir effect

#

enzyme

inducers

ritonavir will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.