The following drugs will decrease isoniazid effect

#

enzyme

inducers

the follwing drugs will Increase isoniazid effect

#

enzyme

Inhibitors

level

The follwing drugs will Increase effect by isoniazid effect

#	enzyme	drug	level
1	2C19	amitriptyline	Weak inhibitor
2	2C9	amitriptyline	Weak inhibitor
3	2C19	atomoxetine	Weak inhibitor
4	2C9	azilsartan	Weak inhibitor
5	2C19	brivaracetam	Weak inhibitor
6	2C9	capecitabine	Weak inhibitor
7	2C19	carisoprodol	Weak inhibitor
8	2C19	celecoxib	Weak inhibitor
9	2C9	celecoxib	Weak inhibitor
10	2C19	chloramphenicol	Weak inhibitor
11	2C19	citalopram	Weak inhibitor
12	2C19	clobazam	Weak inhibitor
13	2C19	clomipramine	Weak inhibitor
14	2C19	clopidogrel	Weak inhibitor
15	2C9	clopidogrel	Weak inhibitor
16	2C19	cyclophosphamide	Weak inhibitor
17	2C19	diazepam	Weak inhibitor
18	2C9	diclofenac	Weak inhibitor
19	2C19	doxepin	Weak inhibitor
20	2C9	doxepin	Weak inhibitor
21	2C19	escitalopram	Weak inhibitor
22	2C19	esomeprazole	Weak inhibitor
23	2C19	flibanserin	Weak inhibitor
24	2C9	fluoxetine	Weak inhibitor
25	2C9	fluvastatin	Weak inhibitor
26	2C9	glibenclamide	Weak inhibitor
27	2C9	glimepiride	Weak inhibitor
28	2C9	glipizide	Weak inhibitor
29	2C9	glyburide	Weak inhibitor
30	2C19	hexobarbital	Weak inhibitor
31	2C9	ibuprofen	Weak inhibitor
32	2C19	imipramine	Weak inhibitor
33	2C19	indomethacin	Weak inhibitor
34	2C9	irbesartan	Weak inhibitor
35	2C19	labetalol	Weak inhibitor
36	2C19	lansoprazole	Weak inhibitor
37	2C9	lesinurad	Weak inhibitor
38	2C9	lornoxicam	Weak inhibitor
39	2C9	losartan	Weak inhibitor
40	2C19	mavacamten	Weak inhibitor
41	2C9	meloxicam	Weak inhibitor
42	2C19	moclobemide	Weak inhibitor
43	2C9	nateglinide	Weak inhibitor
44	2C19	nelfinavir	Weak inhibitor
45	2C19	nilutamide	Weak inhibitor
46	2C9	olodaterol	Weak inhibitor
47	2C19	omeprazole	Weak inhibitor
48	2C19	ospemifene	Weak inhibitor
49	2C9	ospemifene	Weak inhibitor
50	2C19	pantoprazole	Weak inhibitor
51	2C19	phenobarbitone	Weak inhibitor
52	2C19	phenytoin	Weak inhibitor
53	2C9	phenytoin	Weak inhibitor
54	2C9	piroxicam	Weak inhibitor
55	2C19	pomalidomide	Weak inhibitor
56	2C19	primidone	Weak inhibitor
57	2C19	progesterone	Weak inhibitor
58	2C19	proguanil	Weak inhibitor
59	2C19	propranolol	Weak inhibitor
60	2C19	r-mephobarbital	Weak inhibitor
61	2C19	r-warfarin	Weak inhibitor
62	2C9	rosiglitazone	Weak inhibitor
63	2C19	s-mephenytoin	Weak inhibitor
64	2C9	s-warfarin	Weak inhibitor
65	2C9	suprofen	Weak inhibitor
66	2C19	suvorexant	Weak inhibitor
67	2C9	tamoxifen	Weak inhibitor
68	2C19	teniposide	Weak inhibitor
69	2C19	tofacitinib	Weak inhibitor
70	2C9	tolbutamide	Weak inhibitor
71	2C9	torsemide	Weak inhibitor
72	2C9	valproic acid	Weak inhibitor
73	2C19	venlafaxine	Weak inhibitor
74	2C9	venlafaxine	Weak inhibitor
75	2C19	vilazodone	Weak inhibitor
76	2C19	voriconazole	Weak inhibitor
77	2C9	voriconazole	Weak inhibitor
78	2C9	zafirlukast	Weak inhibitor

The following drugs will decreased effect by isoniazid effect

#	enzyme	drug
1	2E1	acetaminophen
2	2E1	aniline
3	2E1	chlorzoxazone
4	2E1	enflurane
5	2E1	ethanol
6	2E1	halothane
7	2E1	isoflurane
8	2E1	methoxyflurane
9	2D6	metoclopramide
10	2D6	mexiletine
11	2D6	minaprine
12	2E1	n,n-dimethylformamide
13	2D6	netupitant/palonosetron
14	2D6	nortriptyline
15	2D6	ondansetron
16	2D6	oxycodone
17	2D6	paroxetine
18	2D6	perhexiline
19	2D6	perphenazine
20	2D6	phenacetin
21	2D6	phenformin
22	2D6	pimavanserin
23	2D6	pomalidomide
24	2D6	ponatinib
25	2D6	promethazine
26	2D6	propafenone
27	2D6	propranolol
28	2D6	rucaparib
29	2E1	sevoflurane
30	2D6	sparteine
31	2D6	tamoxifen
32	2D6	tetrabenzine
33	2E1	theophylline
34	2D6	thioridazine
35	2D6	timolol
36	2D6	tramadol
37	2D6	umeclidinium
38	2D6	valbenazine
39	2D6	venlafaxine
40	2D6	vilazodone
41	2D6	zuclopenthixol

will decrease isoniazid effect

#

enzyme

inducers

isoniazid will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.