The following drugs will decrease fluconazole effect

#

enzyme

inducers

the follwing drugs will Increase fluconazole effect

#

enzyme

Inhibitors

level

The follwing drugs will Increase effect by fluconazole effect

#	enzyme	drug	level
1	3A457	abemaciclib	Moderate inhibitor
2	3A457	abiraterone	Moderate inhibitor
3	3A457	acalabrutinib	Moderate inhibitor
4	3A457	alectinib	Moderate inhibitor
5	3A457	alfentanil	Moderate inhibitor
6	3A457	alprazolam	Moderate inhibitor
7	2C9	amitriptyline	Moderate inhibitor
8	3A457	amitriptyline	Moderate inhibitor
9	2C19	amitriptyline	Moderate inhibitor
10	3A457	amlodipine	Moderate inhibitor
11	3A457	apixaban	Moderate inhibitor
12	3A457	aprepitant	Moderate inhibitor
13	3A457	aripiprazole	Moderate inhibitor
14	3A457	astemizole	Moderate inhibitor
15	2C19	atomoxetine	Moderate inhibitor
16	3A457	atorvastatin	Moderate inhibitor
17	3A457	avanafil	Moderate inhibitor
18	3A457	axitinib	Moderate inhibitor
19	2C9	azilsartan	Moderate inhibitor
20	3A457	boceprevir	Moderate inhibitor
21	3A457	bosutinib	Moderate inhibitor
22	3A457	brexpiprazole	Moderate inhibitor
23	3A457	brigatinib	Moderate inhibitor
24	2C19	brivaracetam	Moderate inhibitor
25	3A457	buspirone	Moderate inhibitor
26	3A457	cafergot	Moderate inhibitor
27	3A457	caffeine	Moderate inhibitor
28	2C9	capecitabine	Moderate inhibitor
29	3A457	carbamazepine	Moderate inhibitor
30	3A457	cariprazine	Moderate inhibitor
31	2C19	carisoprodol	Moderate inhibitor
32	2C9	celecoxib	Moderate inhibitor
33	2C19	celecoxib	Moderate inhibitor
34	3A457	ceritinib	Moderate inhibitor
35	3A457	cerivastatin	Moderate inhibitor
36	2C19	chloramphenicol	Moderate inhibitor
37	3A457	chlorpheniramine	Moderate inhibitor
38	3A457	cilostazol	Moderate inhibitor
39	3A457	cisapride	Moderate inhibitor
40	3A457	citalopram	Moderate inhibitor
41	2C19	citalopram	Moderate inhibitor
42	3A457	clarithromycin	Moderate inhibitor
43	3A457	clobazam	Moderate inhibitor
44	2C19	clobazam	Moderate inhibitor
45	2C19	clomipramine	Moderate inhibitor
46	2C9	clopidogrel	Moderate inhibitor
47	3A457	clopidogrel	Moderate inhibitor
48	2C19	clopidogrel	Moderate inhibitor
49	3A457	cobimetinib	Moderate inhibitor
50	3A457	cocaine	Moderate inhibitor
51	3A457	codeine	Moderate inhibitor
52	3A457	colchicine	Moderate inhibitor
53	3A457	copanlisib	Moderate inhibitor
54	3A457	crizotinib	Moderate inhibitor
55	2C19	cyclophosphamide	Moderate inhibitor
56	3A457	cyclosporine	Moderate inhibitor
57	3A457	dabrafenib	Moderate inhibitor
58	3A457	daclatasvir	Moderate inhibitor
59	3A457	dapsone	Moderate inhibitor
60	3A457	deflazacort	Moderate inhibitor
61	3A457	dexamethasone	Moderate inhibitor
62	3A457	dextromethorphan	Moderate inhibitor
63	3A457	diazepam	Moderate inhibitor
64	2C19	diazepam	Moderate inhibitor
65	2C9	diclofenac	Moderate inhibitor
66	3A457	diltiazem	Moderate inhibitor
67	3A457	docetaxel	Moderate inhibitor
68	3A457	dolutegravir	Moderate inhibitor
69	3A457	domperidone	Moderate inhibitor
70	2C9	doxepin	Moderate inhibitor
71	3A457	doxepin	Moderate inhibitor
72	2C19	doxepin	Moderate inhibitor
73	3A457	elagolix	Moderate inhibitor
74	3A457	elbasvir/grazoprevir	Moderate inhibitor
75	3A457	eliglustat	Moderate inhibitor
76	3A457	enzalutamide	Moderate inhibitor
77	3A457	eplerenone	Moderate inhibitor
78	3A457	erythromycin2	Moderate inhibitor
79	3A457	escitalopram	Moderate inhibitor
80	2C19	escitalopram	Moderate inhibitor
81	3A457	esomeprazole	Moderate inhibitor
82	2C19	esomeprazole	Moderate inhibitor
83	3A457	estradiol	Moderate inhibitor
84	3A457	felodipine	Moderate inhibitor
85	3A457	fentanyl	Moderate inhibitor
86	3A457	finasteride	Moderate inhibitor
87	3A457	flibanserin	Moderate inhibitor
88	2C19	flibanserin	Moderate inhibitor
89	2C9	fluoxetine	Moderate inhibitor
90	2C9	fluvastatin	Moderate inhibitor
91	3A457	gleevec	Moderate inhibitor
92	2C9	glibenclamide	Moderate inhibitor
93	2C9	glimepiride	Moderate inhibitor
94	2C9	glipizide	Moderate inhibitor
95	2C9	glyburide	Moderate inhibitor
96	3A457	haloperidol	Moderate inhibitor
97	2C19	hexobarbital	Moderate inhibitor
98	3A457	hydrocortisone	Moderate inhibitor
99	3A457	ibrutinib	Moderate inhibitor
100	2C9	ibuprofen	Moderate inhibitor
101	3A457	idelalisib	Moderate inhibitor
102	2C19	imipramine	Moderate inhibitor
103	3A457	indacaterol	Moderate inhibitor
104	3A457	indinavir	Moderate inhibitor
105	2C19	indomethacin	Moderate inhibitor
106	2C9	irbesartan	Moderate inhibitor
107	3A457	irinotecan	Moderate inhibitor
108	3A457	isavuconazonium	Moderate inhibitor
109	3A457	ivabradine	Moderate inhibitor
110	3A457	ivacaftor	Moderate inhibitor
111	3A457	LAAM	Moderate inhibitor
112	2C19	labetalol	Moderate inhibitor
113	3A457	lansoprazole	Moderate inhibitor
114	2C19	lansoprazole	Moderate inhibitor
115	3A457	lenvatinib	Moderate inhibitor
116	3A457	lercanidipine	Moderate inhibitor
117	2C9	lesinurad	Moderate inhibitor
118	3A457	lidocaine	Moderate inhibitor
119	3A457	linagliptin	Moderate inhibitor
120	2C9	lornoxicam	Moderate inhibitor
121	2C9	losartan	Moderate inhibitor
122	3A457	lovastatin	Moderate inhibitor
123	3A457	macitentan	Moderate inhibitor
124	3A457	mavacamten	Moderate inhibitor
125	2C19	mavacamten	Moderate inhibitor
126	2C9	meloxicam	Moderate inhibitor
127	3A457	methadone	Moderate inhibitor
128	3A457	midazolam	Moderate inhibitor
129	2C19	moclobemide	Moderate inhibitor
130	3A457	naldemedine	Moderate inhibitor
131	3A457	naloxegol	Moderate inhibitor
132	2C9	nateglinide	Moderate inhibitor
133	3A457	nateglinide	Moderate inhibitor
134	3A457	nelfinavir	Moderate inhibitor
135	2C19	nelfinavir	Moderate inhibitor
136	3A457	neratinib	Moderate inhibitor
137	3A457	netupitant/palonosetron	Moderate inhibitor
138	3A457	nevirapine	Moderate inhibitor
139	3A457	nifedipine	Moderate inhibitor
140	2C19	nilutamide	Moderate inhibitor
141	3A457	nirmatrelvir	Moderate inhibitor
142	3A457	nisoldipine	Moderate inhibitor
143	3A457	nitrendipine	Moderate inhibitor
144	3A457	olaparib	Moderate inhibitor
145	2C9	olodaterol	Moderate inhibitor
146	3A457	omeprazole	Moderate inhibitor
147	2C19	omeprazole	Moderate inhibitor
148	3A457	ondansetron	Moderate inhibitor
149	3A457	osimertinib	Moderate inhibitor
150	2C9	ospemifene	Moderate inhibitor
151	3A457	ospemifene	Moderate inhibitor
152	2C19	ospemifene	Moderate inhibitor
153	3A457	palbociclib	Moderate inhibitor
154	3A457	panobinostat	Moderate inhibitor
155	3A457	pantoprazole	Moderate inhibitor
156	2C19	pantoprazole	Moderate inhibitor
157	3A457	perampanel	Moderate inhibitor
158	2C19	phenobarbitone	Moderate inhibitor
159	2C9	phenytoin	Moderate inhibitor
160	2C19	phenytoin	Moderate inhibitor
161	3A457	pimavanserin	Moderate inhibitor
162	3A457	pimozide	Moderate inhibitor
163	2C9	piroxicam	Moderate inhibitor
164	3A457	pomalidomide	Moderate inhibitor
165	2C19	pomalidomide	Moderate inhibitor
166	3A457	ponatinib	Moderate inhibitor
167	2C19	primidone	Moderate inhibitor
168	3A457	progesterone	Moderate inhibitor
169	2C19	progesterone	Moderate inhibitor
170	2C19	proguanil	Moderate inhibitor
171	3A457	propranolol	Moderate inhibitor
172	2C19	propranolol	Moderate inhibitor
173	3A457	quetiapine	Moderate inhibitor
174	3A457	quinidine	Moderate inhibitor
175	3A457	quinine	Moderate inhibitor
176	2C19	r-mephobarbital	Moderate inhibitor
177	2C19	r-warfarin	Moderate inhibitor
178	3A457	regorafenib	Moderate inhibitor
179	3A457	ribociclib	Moderate inhibitor
180	3A457	rilpivirine	Moderate inhibitor
181	3A457	risperidone	Moderate inhibitor
182	3A457	ritonavir	Moderate inhibitor
183	3A457	rivaroxaban	Moderate inhibitor
184	3A457	roflumilast	Moderate inhibitor
185	3A457	rolapitant	Moderate inhibitor
186	3A457	romidepsin	Moderate inhibitor
187	2C9	rosiglitazone	Moderate inhibitor
188	3A457	rucaparib	Moderate inhibitor
189	3A457	ruxolitinib	Moderate inhibitor
190	2C19	s-mephenytoin	Moderate inhibitor
191	2C9	s-warfarin	Moderate inhibitor
192	3A457	salmeterol	Moderate inhibitor
193	3A457	saquinavir	Moderate inhibitor
194	3A457	selexipag	Moderate inhibitor
195	3A457	sildenafil	Moderate inhibitor
196	3A457	simeprevir	Moderate inhibitor
197	3A457	simvastatin	Moderate inhibitor
198	3A457	sirolimus	Moderate inhibitor
199	3A457	sonidegib	Moderate inhibitor
200	3A457	sorafenib	Moderate inhibitor
201	3A457	sunitinib	Moderate inhibitor
202	2C9	suprofen	Moderate inhibitor
203	3A457	suvorexant	Moderate inhibitor
204	2C19	suvorexant	Moderate inhibitor
205	3A457	tacrolimus(fk506)	Moderate inhibitor
206	2C9	tamoxifen	Moderate inhibitor
207	3A457	tamoxifen	Moderate inhibitor
208	3A457	tasimelteon	Moderate inhibitor
209	3A457	taxol	Moderate inhibitor
210	3A457	telaprevir	Moderate inhibitor
211	3A457	telithromycin	Moderate inhibitor
212	2C19	teniposide	Moderate inhibitor
213	3A457	terfenadine	Moderate inhibitor
214	3A457	testosterone	Moderate inhibitor
215	3A457	ticagrelor	Moderate inhibitor
216	3A457	tofacitinib	Moderate inhibitor
217	2C19	tofacitinib	Moderate inhibitor
218	2C9	tolbutamide	Moderate inhibitor
219	3A457	tolvaptan	Moderate inhibitor
220	3A457	torisel	Moderate inhibitor
221	2C9	torsemide	Moderate inhibitor
222	3A457	tramadol	Moderate inhibitor
223	3A457	trazodone	Moderate inhibitor
224	3A457	valbenazine	Moderate inhibitor
225	2C9	valproic acid	Moderate inhibitor
226	3A457	vandetanib	Moderate inhibitor
227	3A457	velpatasvir	Moderate inhibitor
228	3A457	vemurafenib	Moderate inhibitor
229	3A457	venetoclax	Moderate inhibitor
230	2C9	venlafaxine	Moderate inhibitor
231	3A457	venlafaxine	Moderate inhibitor
232	2C19	venlafaxine	Moderate inhibitor
233	3A457	verapamil	Moderate inhibitor
234	3A457	vilazodone	Moderate inhibitor
235	2C19	vilazodone	Moderate inhibitor
236	3A457	vincristine	Moderate inhibitor
237	3A457	vorapaxar	Moderate inhibitor
238	2C9	voriconazole	Moderate inhibitor
239	3A457	voriconazole	Moderate inhibitor
240	2C19	voriconazole	Moderate inhibitor
241	2C9	zafirlukast	Moderate inhibitor
242	3A457	zaleplon	Moderate inhibitor
243	3A457	ziprasidone	Moderate inhibitor
244	3A457	zolpidem	Moderate inhibitor

will decrease fluconazole effect

#

enzyme

inducers

fluconazole will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.