The following drugs will decrease enzalutamide effect

#	enzyme	inducers
0	2C8	rifampin
1	3A457	barbiturates
2	3A457	brigatinib
3	3A457	carbamazepine
4	3A457	clobazam
5	3A457	dabrafenib
6	3A457	efavirenz
7	3A457	elagolix
8	3A457	enzalutamide
9	3A457	eslicarbazepine
10	3A457	glucocorticoids
11	3A457	letermovir
12	3A457	lorlatinib
13	3A457	modafinil
14	3A457	nevirapine
15	3A457	oxcarbazepine
16	3A457	perampanel
17	3A457	phenobarbital
18	3A457	phenytoin
19	3A457	pioglitazone
20	3A457	rifabutin
21	3A457	rifampin
22	3A457	St. John's Wort
23	3A457	telotristat
24	3A457	troglitazone
25	3A457	vemurafenib

the follwing drugs will Increase enzalutamide effect

#	enzyme	Inhibitors	level
0	2C8	abiraterone	Weak inhibitor
1	3A457	amiodarone	under review
2	3A457	aprepitant	Moderate inhibitor
3	3A457	atomoxetine
4	3A457	boceprevir	under review
5	3A457	ceritinib	Strong inhibitor
6	3A457	chloramphenicol	In-Vitro Only
7	3A457	cimetidine
8	3A457	ciprofloxacin	under review
9	3A457	clarithromycin	Strong inhibitor
10	2C8	clopidogrel	Moderate inhibitor
11	3A457	crizotinib	Moderate inhibitor
12	2C8	deferasirox	Moderate inhibitor
13	3A457	delaviridine	under review
14	3A457	diethyl-dithiocarbamate
15	3A457	diltiazem	Moderate inhibitor
16	3A457	entrectinib
17	3A457	erythromycin	Moderate inhibitor
18	3A457	esomeprazole
19	3A457	fluconazole	Moderate inhibitor
20	3A457	fluvoxamine	under review
21	2C8	gemfibrozil	Strong inhibitor
22	3A457	gestodene	under review
23	2C8	glitazones	In-Vitro Only
24	3A457	grapefruit juice	Moderate inhibitor
25	3A457	idelalisib	Strong inhibitor
26	3A457	imatinib	under review
27	3A457	indinavir	Strong inhibitor
28	3A457	itraconazole	Strong inhibitor
29	3A457	ivacaftor
30	3A457	ketoconazole	Strong inhibitor
31	2C8	lapatinib	Weak inhibitor
32	3A457	lesinurad
33	2C8	letermovir	In-Vitro Only
34	3A457	letermovir
35	3A457	mibefradil	Strong inhibitor
36	3A457	mifepristone	under review
37	2C8	montelukast	In-Vitro Only
38	3A457	nefazodone	Strong inhibitor
39	3A457	nelfinavir	Strong inhibitor
40	3A457	netupitant/palonosetron	Moderate inhibitor
41	3A457	norfloxacin	under review
42	3A457	norfluoxetine	under review
43	3A457	omeprazole	Weak inhibitor
44	3A457	pantoprazole
45	2C8	perampanel	In-Vitro Only
46	3A457	perampanel
47	2C8	quercetin	In-Vitro Only
48	3A457	quercetin
49	3A457	regorafenib	under review
50	3A457	ribociclib	Strong inhibitor
51	3A457	ritonavir	Strong inhibitor
52	3A457	rucaparib
53	3A457	saquinavir	Strong inhibitor
54	3A457	simeprevir
55	3A457	starfruit	under review
56	3A457	telaprevir	under review
57	3A457	telithromycin	Strong inhibitor
58	2C8	teriflunomide	Moderate inhibitor
59	3A457	ticagrelor
60	2C8	trimethoprim	Moderate inhibitor
61	2C8	tucatinib	Weak inhibitor
62	3A457	tucatinib	Strong inhibitor
63	3A457	verapamil	Moderate inhibitor
64	3A457	voriconazole	Strong inhibitor

The following drugs will decreased effect by enzalutamide effect

#	enzyme	drug
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	3A457	alectinib
5	3A457	alfentanil
6	3A457	alprazolam
7	2C19	amitriptyline
8	2C9	amitriptyline
9	3A457	amitriptyline
10	3A457	amlodipine
11	3A457	apixaban
12	3A457	aprepitant
13	3A457	aripiprazole
14	3A457	astemizole
15	2C19	atomoxetine
16	3A457	atorvastatin
17	3A457	avanafil
18	3A457	axitinib
19	2C9	azilsartan
20	3A457	boceprevir
21	3A457	bosutinib
22	3A457	brexpiprazole
23	3A457	brigatinib
24	2C19	brivaracetam
25	3A457	buspirone
26	3A457	cafergot
27	3A457	caffeine
28	2C9	capecitabine
29	3A457	carbamazepine
30	3A457	cariprazine
31	2C19	carisoprodol
32	2C19	celecoxib
33	2C9	celecoxib
34	3A457	ceritinib
35	3A457	cerivastatin
36	2C19	chloramphenicol
37	3A457	chlorpheniramine
38	3A457	cilostazol
39	3A457	cisapride
40	2C19	citalopram
41	3A457	citalopram
42	3A457	clarithromycin
43	2C19	clobazam
44	3A457	clobazam
45	2C19	clomipramine
46	2C19	clopidogrel
47	2C9	clopidogrel
48	3A457	clopidogrel
49	3A457	cobimetinib
50	3A457	cocaine
51	3A457	codeine
52	3A457	colchicine
53	3A457	copanlisib
54	3A457	crizotinib
55	2C19	cyclophosphamide
56	3A457	cyclosporine
57	3A457	dabrafenib
58	3A457	daclatasvir
59	3A457	dapsone
60	3A457	deflazacort
61	3A457	dexamethasone
62	3A457	dextromethorphan
63	2C19	diazepam
64	3A457	diazepam
65	2C9	diclofenac
66	3A457	diltiazem
67	3A457	docetaxel
68	3A457	dolutegravir
69	3A457	domperidone
70	2C19	doxepin
71	2C9	doxepin
72	3A457	doxepin
73	3A457	elagolix
74	3A457	elbasvir/grazoprevir
75	3A457	eliglustat
76	3A457	enzalutamide
77	3A457	eplerenone
78	3A457	erythromycin2
79	2C19	escitalopram
80	3A457	escitalopram
81	2C19	esomeprazole
82	3A457	esomeprazole
83	3A457	estradiol
84	3A457	felodipine
85	3A457	fentanyl
86	3A457	finasteride
87	2C19	flibanserin
88	3A457	flibanserin
89	2C9	fluoxetine
90	2C9	fluvastatin
91	3A457	gleevec
92	2C9	glibenclamide
93	2C9	glimepiride
94	2C9	glipizide
95	2C9	glyburide
96	3A457	haloperidol
97	2C19	hexobarbital
98	3A457	hydrocortisone
99	3A457	ibrutinib
100	2C9	ibuprofen
101	3A457	idelalisib
102	2C19	imipramine
103	3A457	indacaterol
104	3A457	indinavir
105	2C19	indomethacin
106	2C9	irbesartan
107	3A457	irinotecan
108	3A457	isavuconazonium
109	3A457	ivabradine
110	3A457	ivacaftor
111	3A457	LAAM
112	2C19	labetalol
113	2C19	lansoprazole
114	3A457	lansoprazole
115	3A457	lenvatinib
116	3A457	lercanidipine
117	2C9	lesinurad
118	3A457	lidocaine
119	3A457	linagliptin
120	2C9	lornoxicam
121	2C9	losartan
122	3A457	lovastatin
123	3A457	macitentan
124	2C19	mavacamten
125	3A457	mavacamten
126	2C9	meloxicam
127	3A457	methadone
128	3A457	midazolam
129	2C19	moclobemide
130	3A457	naldemedine
131	3A457	naloxegol
132	2C9	nateglinide
133	3A457	nateglinide
134	2C19	nelfinavir
135	3A457	nelfinavir
136	3A457	neratinib
137	3A457	netupitant/palonosetron
138	3A457	nevirapine
139	3A457	nifedipine
140	2C19	nilutamide
141	3A457	nirmatrelvir
142	3A457	nisoldipine
143	3A457	nitrendipine
144	3A457	olaparib
145	2C9	olodaterol
146	2C19	omeprazole
147	3A457	omeprazole
148	3A457	ondansetron
149	3A457	osimertinib
150	2C19	ospemifene
151	2C9	ospemifene
152	3A457	ospemifene
153	3A457	palbociclib
154	3A457	panobinostat
155	2C19	pantoprazole
156	3A457	pantoprazole
157	3A457	perampanel
158	2C19	phenobarbitone
159	2C19	phenytoin
160	2C9	phenytoin
161	3A457	pimavanserin
162	3A457	pimozide
163	2C9	piroxicam
164	2C19	pomalidomide
165	3A457	pomalidomide
166	3A457	ponatinib
167	2C19	primidone
168	2C19	progesterone
169	3A457	progesterone
170	2C19	proguanil
171	2C19	propranolol
172	3A457	propranolol
173	3A457	quetiapine
174	3A457	quinidine
175	3A457	quinine
176	2C19	r-mephobarbital
177	2C19	r-warfarin
178	3A457	regorafenib
179	3A457	ribociclib
180	3A457	rilpivirine
181	3A457	risperidone
182	3A457	ritonavir
183	3A457	rivaroxaban
184	3A457	roflumilast
185	3A457	rolapitant
186	3A457	romidepsin
187	2C9	rosiglitazone
188	3A457	rucaparib
189	3A457	ruxolitinib
190	2C19	s-mephenytoin
191	2C9	s-warfarin
192	3A457	salmeterol
193	3A457	saquinavir
194	3A457	selexipag
195	3A457	sildenafil
196	3A457	simeprevir
197	3A457	simvastatin
198	3A457	sirolimus
199	3A457	sonidegib
200	3A457	sorafenib
201	3A457	sunitinib
202	2C9	suprofen
203	2C19	suvorexant
204	3A457	suvorexant
205	3A457	tacrolimus(fk506)
206	2C9	tamoxifen
207	3A457	tamoxifen
208	3A457	tasimelteon
209	3A457	taxol
210	3A457	telaprevir
211	3A457	telithromycin
212	2C19	teniposide
213	3A457	terfenadine
214	3A457	testosterone
215	3A457	ticagrelor
216	2C19	tofacitinib
217	3A457	tofacitinib
218	2C9	tolbutamide
219	3A457	tolvaptan
220	3A457	torisel
221	2C9	torsemide
222	3A457	tramadol
223	3A457	trazodone
224	3A457	valbenazine
225	2C9	valproic acid
226	3A457	vandetanib
227	3A457	velpatasvir
228	3A457	vemurafenib
229	3A457	venetoclax
230	2C19	venlafaxine
231	2C9	venlafaxine
232	3A457	venlafaxine
233	3A457	verapamil
234	2C19	vilazodone
235	3A457	vilazodone
236	3A457	vincristine
237	3A457	vorapaxar
238	2C19	voriconazole
239	2C9	voriconazole
240	3A457	voriconazole
241	2C9	zafirlukast
242	3A457	zaleplon
243	3A457	ziprasidone
244	3A457	zolpidem

will decrease enzalutamide effect

#

enzyme

inducers

enzalutamide will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.