The following drugs will decrease cimetidine effect

#

enzyme

inducers

the follwing drugs will Increase cimetidine effect

#

enzyme

Inhibitors

level

The follwing drugs will Increase effect by cimetidine effect

#	enzyme	drug	level
1	3A457	abemaciclib
2	3A457	abiraterone
3	3A457	acalabrutinib
4	1A2	acetaminophen	Weak inhibitor
5	3A457	alectinib
6	3A457	alfentanil
7	3A457	alprazolam
8	2D6	alprenolol	Weak inhibitor
9	2D6	amitriptyline	Weak inhibitor
10	1A2	amitriptyline	Weak inhibitor
11	3A457	amitriptyline
12	2C19	amitriptyline	Weak inhibitor
13	3A457	amlodipine
14	2D6	amphetamine	Weak inhibitor
15	3A457	apixaban
16	1A2	apremilast	Weak inhibitor
17	3A457	aprepitant
18	3A457	aripiprazole
19	3A457	astemizole
20	2D6	atomoxetine	Weak inhibitor
21	2C19	atomoxetine	Weak inhibitor
22	3A457	atorvastatin
23	3A457	avanafil
24	3A457	axitinib
25	3A457	boceprevir
26	3A457	bosutinib
27	2D6	brexpiprazole	Weak inhibitor
28	3A457	brexpiprazole
29	3A457	brigatinib
30	2C19	brivaracetam	Weak inhibitor
31	2D6	bufuralol	Weak inhibitor
32	3A457	buspirone
33	3A457	cafergot
34	1A2	caffeine	Weak inhibitor
35	3A457	caffeine
36	3A457	carbamazepine
37	2D6	cariprazine	Weak inhibitor
38	3A457	cariprazine
39	2C19	carisoprodol	Weak inhibitor
40	2D6	carvedilol	Weak inhibitor
41	2C19	celecoxib	Weak inhibitor
42	3A457	ceritinib
43	3A457	cerivastatin
44	2C19	chloramphenicol	Weak inhibitor
45	2D6	chlorpheniramine	Weak inhibitor
46	3A457	chlorpheniramine
47	2D6	chlorpromazine	Weak inhibitor
48	3A457	cilostazol
49	3A457	cisapride
50	2D6	citalopram	Weak inhibitor
51	3A457	citalopram
52	2C19	citalopram	Weak inhibitor
53	3A457	clarithromycin
54	3A457	clobazam
55	2C19	clobazam	Weak inhibitor
56	2D6	clomipramine	Weak inhibitor
57	1A2	clomipramine	Weak inhibitor
58	2C19	clomipramine	Weak inhibitor
59	2D6	clonidine	Weak inhibitor
60	3A457	clopidogrel
61	2C19	clopidogrel	Weak inhibitor
62	1A2	clozapine	Weak inhibitor
63	3A457	cobimetinib
64	3A457	cocaine
65	2D6	codeine	Weak inhibitor
66	3A457	codeine
67	3A457	colchicine
68	3A457	copanlisib
69	3A457	crizotinib
70	1A2	cyclobenzaprine	Weak inhibitor
71	2C19	cyclophosphamide	Weak inhibitor
72	3A457	cyclosporine
73	3A457	dabrafenib
74	3A457	daclatasvir
75	3A457	dapsone
76	2D6	debrisoquine	Weak inhibitor
77	3A457	deflazacort
78	2D6	desipramine	Weak inhibitor
79	2D6	deutetrabenazine	Weak inhibitor
80	3A457	dexamethasone
81	2D6	dexfenfluramine	Weak inhibitor
82	2D6	dextromethorphan	Weak inhibitor
83	3A457	dextromethorphan
84	3A457	diazepam
85	2C19	diazepam	Weak inhibitor
86	3A457	diltiazem
87	3A457	docetaxel
88	3A457	dolutegravir
89	3A457	domperidone
90	2D6	donepezil	Weak inhibitor
91	2D6	doxepin	Weak inhibitor
92	1A2	doxepin	Weak inhibitor
93	3A457	doxepin
94	2C19	doxepin	Weak inhibitor
95	1A2	duloxetine	Weak inhibitor
96	3A457	elagolix
97	3A457	elbasvir/grazoprevir
98	2D6	eliglustat	Weak inhibitor
99	3A457	eliglustat
100	2D6	encainide	Weak inhibitor
101	3A457	enzalutamide
102	3A457	eplerenone
103	3A457	erythromycin2
104	2D6	escitalopram	Weak inhibitor
105	3A457	escitalopram
106	2C19	escitalopram	Weak inhibitor
107	3A457	esomeprazole
108	2C19	esomeprazole	Weak inhibitor
109	1A2	estradiol	Weak inhibitor
110	3A457	estradiol
111	3A457	felodipine
112	3A457	fentanyl
113	3A457	finasteride
114	2D6	flecainide	Weak inhibitor
115	3A457	flibanserin
116	2C19	flibanserin	Weak inhibitor
117	2D6	fluoxetine	Weak inhibitor
118	2D6	fluvoxamine	Weak inhibitor
119	1A2	fluvoxamine	Weak inhibitor
120	3A457	gleevec
121	1A2	haloperidol	Weak inhibitor
122	3A457	haloperidol
123	2C19	hexobarbital	Weak inhibitor
124	3A457	hydrocortisone
125	2D6	ibrutinib	Weak inhibitor
126	3A457	ibrutinib
127	3A457	idelalisib
128	2D6	imipramine	Weak inhibitor
129	1A2	imipramine	Weak inhibitor
130	2C19	imipramine	Weak inhibitor
131	3A457	indacaterol
132	3A457	indinavir
133	2C19	indomethacin	Weak inhibitor
134	3A457	irinotecan
135	3A457	isavuconazonium
136	3A457	ivabradine
137	3A457	ivacaftor
138	3A457	LAAM
139	2C19	labetalol	Weak inhibitor
140	3A457	lansoprazole
141	2C19	lansoprazole	Weak inhibitor
142	3A457	lenvatinib
143	3A457	lercanidipine
144	2D6	lidocaine	Weak inhibitor
145	3A457	lidocaine
146	3A457	linagliptin
147	3A457	lovastatin
148	3A457	macitentan
149	3A457	mavacamten
150	2C19	mavacamten	Weak inhibitor
151	3A457	methadone
152	2D6	metoclopramide	Weak inhibitor
153	2D6	metoprolol	Weak inhibitor
154	2D6	mexiletine	Weak inhibitor
155	1A2	mexiletine	Weak inhibitor
156	3A457	midazolam
157	2D6	minaprine	Weak inhibitor
158	2C19	moclobemide	Weak inhibitor
159	1A2	nabumetone	Weak inhibitor
160	3A457	naldemedine
161	3A457	naloxegol
162	1A2	naproxen	Weak inhibitor
163	3A457	nateglinide
164	2D6	nebivolol	Weak inhibitor
165	3A457	nelfinavir
166	2C19	nelfinavir	Weak inhibitor
167	3A457	neratinib
168	3A457	netupitant/palonosetron
169	3A457	nevirapine
170	3A457	nifedipine
171	2C19	nilutamide	Weak inhibitor
172	3A457	nirmatrelvir
173	3A457	nisoldipine
174	3A457	nitrendipine
175	2D6	nortriptyline	Weak inhibitor
176	1A2	olanzapine	Weak inhibitor
177	3A457	olaparib
178	3A457	omeprazole
179	2C19	omeprazole	Weak inhibitor
180	2D6	ondansetron	Weak inhibitor
181	1A2	ondansetron	Weak inhibitor
182	3A457	ondansetron
183	3A457	osimertinib
184	3A457	ospemifene
185	2C19	ospemifene	Weak inhibitor
186	2D6	oxycodone	Weak inhibitor
187	3A457	palbociclib
188	3A457	panobinostat
189	3A457	pantoprazole
190	2C19	pantoprazole	Weak inhibitor
191	2D6	paroxetine	Weak inhibitor
192	3A457	perampanel
193	2D6	perhexiline	Weak inhibitor
194	2D6	perphenazine	Weak inhibitor
195	2D6	phenacetin	Weak inhibitor
196	1A2	phenacetin	Weak inhibitor
197	2C19	phenobarbitone	Weak inhibitor
198	2C19	phenytoin	Weak inhibitor
199	2D6	pimavanserin	Weak inhibitor
200	3A457	pimavanserin
201	3A457	pimozide
202	1A2	pirfenidone	Weak inhibitor
203	1A2	pomalidomide	Weak inhibitor
204	3A457	pomalidomide
205	2C19	pomalidomide	Weak inhibitor
206	2D6	ponatinib	Weak inhibitor
207	3A457	ponatinib
208	2C19	primidone	Weak inhibitor
209	3A457	progesterone
210	2C19	progesterone	Weak inhibitor
211	2C19	proguanil	Weak inhibitor
212	2D6	promethazine	Weak inhibitor
213	2D6	propafenone	Weak inhibitor
214	2D6	propranolol	Weak inhibitor
215	1A2	propranolol	Weak inhibitor
216	3A457	propranolol
217	2C19	propranolol	Weak inhibitor
218	3A457	quetiapine
219	3A457	quinidine
220	3A457	quinine
221	2C19	r-mephobarbital	Weak inhibitor
222	2C19	r-warfarin	Weak inhibitor
223	3A457	regorafenib
224	3A457	ribociclib
225	3A457	rilpivirine
226	1A2	riluzole	Weak inhibitor
227	2D6	risperidone	Weak inhibitor
228	3A457	risperidone
229	3A457	ritonavir
230	3A457	rivaroxaban
231	1A2	roflumilast	Weak inhibitor
232	3A457	roflumilast
233	3A457	rolapitant
234	3A457	romidepsin
235	1A2	ropivacaine	Weak inhibitor
236	2D6	rucaparib	Weak inhibitor
237	1A2	rucaparib	Weak inhibitor
238	3A457	rucaparib
239	3A457	ruxolitinib
240	2C19	s-mephenytoin	Weak inhibitor
241	3A457	salmeterol
242	3A457	saquinavir
243	3A457	selexipag
244	3A457	sildenafil
245	3A457	simeprevir
246	3A457	simvastatin
247	3A457	sirolimus
248	3A457	sonidegib
249	3A457	sorafenib
250	2D6	sparteine	Weak inhibitor
251	3A457	sunitinib
252	3A457	suvorexant
253	2C19	suvorexant	Weak inhibitor
254	1A2	tacrine	Weak inhibitor
255	3A457	tacrolimus(fk506)
256	2D6	tamoxifen	Weak inhibitor
257	3A457	tamoxifen
258	1A2	tasimelteon	Weak inhibitor
259	3A457	tasimelteon
260	3A457	taxol
261	3A457	telaprevir
262	3A457	telithromycin
263	2C19	teniposide	Weak inhibitor
264	3A457	terfenadine
265	3A457	testosterone
266	2D6	tetrabenzine	Weak inhibitor
267	1A2	theophylline	Weak inhibitor
268	2D6	thioridazine	Weak inhibitor
269	3A457	ticagrelor
270	2D6	timolol	Weak inhibitor
271	1A2	tizanidine	Weak inhibitor
272	3A457	tofacitinib
273	2C19	tofacitinib	Weak inhibitor
274	3A457	tolvaptan
275	3A457	torisel
276	2D6	tramadol	Weak inhibitor
277	3A457	tramadol
278	3A457	trazodone
279	1A2	triamterene	Weak inhibitor
280	2D6	umeclidinium	Weak inhibitor
281	2D6	valbenazine	Weak inhibitor
282	3A457	valbenazine
283	3A457	vandetanib
284	3A457	velpatasvir
285	3A457	vemurafenib
286	3A457	venetoclax
287	2D6	venlafaxine	Weak inhibitor
288	3A457	venlafaxine
289	2C19	venlafaxine	Weak inhibitor
290	1A2	verapamil	Weak inhibitor
291	3A457	verapamil
292	2D6	vilazodone	Weak inhibitor
293	3A457	vilazodone
294	2C19	vilazodone	Weak inhibitor
295	3A457	vincristine
296	3A457	vorapaxar
297	3A457	voriconazole
298	2C19	voriconazole	Weak inhibitor
299	1A2	warfarin	Weak inhibitor
300	3A457	zaleplon
301	1A2	zileuton	Weak inhibitor
302	3A457	ziprasidone
303	1A2	zolmitriptan	Weak inhibitor
304	3A457	zolpidem
305	2D6	zuclopenthixol	Weak inhibitor

will decrease cimetidine effect

#

enzyme

inducers

cimetidine will not affect

Strong inhibitor is one that causes a ≥ 5-fold decrease in the plasma AUC values or more than 80% decrease in clearance.
Moderate inhibitor is one that causes a 2 fold to < 5-fold decrease in the plasma AUC values or 50-80% decrease in clearance.
Weak inhibitor is one that causes a ≥ 1.25-fold but < 2-fold decrease in the plasma AUC values or 20-50% decrease in clearance.
In-Vitro Only In-Vitro Only Inhibitor strength.
under review Inhibitor strength level is under review.