Finasteride is a drug that blocks the conversion of male testosterone to Dihydrotestosterone.
Finasteride is used to treat symptoms of benign prostatic hyperplasia. Finasteride reduces the size of the??prostate??and thus improves urine flow.
Finasteride is also used to treat androgenic alopecia, as it has been shown to be effective in treating mild to moderate alopecia.

Category

Chemical class: 4-Azasteroid compound
Therapeutic class: Benign prostatic hyperplasia agent, hair growth stimulant

Pregnancy category: X

Indications

To treat symptomatic benign prostatic hyperplasia; to reduce the risk of symptomatic progression of benign prostatic hyperplasia when given with doxazocin
Adults. 5 mg daily. To treat male-pattern baldness
Adults.1 mg daily. Route Onset Peak Duration P.O.* Unknown 8 hr 24 hr P.O. In 3 mo Unknown Unknown

Mechanism of Action

Inhibits 5-alpha reductase, an intracellular enzyme that converts testosterone to its finasteride 440 * For benign prostatic hyperplasia. With single-dose therapy; 2 wk with multiple-dose therapy. For male-pattern baldness. metabolite (5-alpha dihydrotestosterone) in liver, prostate, and skin. The metabolite is a potent androgen partially responsible for benign prostatic hyperplasia and hair loss.

Contraindications

Age (childhood), hypersensitivity to finasteride, sex (female)

Interactions

theophylline: Decreased theophylline level

Side Efect

CNS: Asthenia, dizziness, headache
CV: Hypotension, peripheral edema
EENT: Lip swelling, rhinitis
ENDO: Gynecomastia
GI: Abdominal pain, diarrhea
GU: Decreased ejaculatory volume, decreased libido, impotence, testicular pain
MS: Back pain
RESP: Dyspnea
SKIN: Pruritus, rash, urticaria
Other: Angioedema

Cautions

Expect patient to have a digital rectal examination of the prostate before and periodically during finasteride therapy.

PATIENT SAFTY

WARNING Urge patient and female partners to use reliable contraception during therapy because semen of men who take drug can harm male fetuses. Caution women and children not to handle broken tablets.

Explain how to take drug, and urge patient to follow instructions that accompany it.

Inform patient that drug may cause decreased ejaculatory volume, decreased libido, and impotence.

Urge patient to have periodic follow-up to determine drug effectiveness.

Trade Name & Company Name

Trade name	Company name
PROHAIR	HAYAT PHARMACEUTICAL INDUSTRIES
PROSNORM	HAYAT PHARMACEUTICAL INDUSTRIES
PROPECIA	MERCK SHARP & DOHME
PROSCAR	MERCK SHARP & DOHME
FINASID 5MG FILM COATED TABLET	SAJA-SAUDI ARABIAN JAPANESE PHARMACEUTICAL CO
PROSTID 5MG FC TABLETS	SPIMACO
FINISCAR 5MG FC TABLETS	TABUK PHARMACEUTICAL MANUFACTURING CO.

effect of Finasteride in Pregnancy, Fetal Health and Breast feeding

the follwing drugs will increse Finasteride by inhepiting cyp450

amiodarone ; aprepitant ; atomoxetine ; boceprevir ; ceritinib ; chloramphenicol ; cimetidine ; ciprofloxacin ; clarithromycin ; crizotinib ; delaviridine ; diethyl-dithiocarbamate ; diltiazem ; entrectinib ; erythromycin ; esomeprazole ; fluconazole ; fluvoxamine ; gestodene ; grapefruit juice ; idelalisib ; imatinib ; indinavir ; itraconazole ; ivacaftor ; ketoconazole ; lesinurad ; letermovir ; mibefradil ; mifepristone ; nefazodone ; nelfinavir ; netupitant/palonosetron ; norfloxacin ; norfluoxetine ; omeprazole ; pantoprazole ; perampanel ; quercetin ; regorafenib ; ribociclib ; ritonavir ; rucaparib ; saquinavir ; simeprevir ; starfruit ; telaprevir ; telithromycin ; ticagrelor ; tucatinib ; verapamil ; voriconazole ;

the follwing drugs will decrease Finasteride by inhancing cyp450

barbiturates ; brigatinib ; carbamazepine ; clobazam ; dabrafenib ; efavirenz ; elagolix ; enzalutamide ; eslicarbazepine ; glucocorticoids ; letermovir ; lorlatinib ; modafinil ; nevirapine ; oxcarbazepine ; perampanel ; phenobarbital ; phenytoin ; pioglitazone ; rifabutin ; rifampin ; St. John's Wort ; telotristat ; troglitazone ; vemurafenib ;

5-alpha-reductase inhibitors

...

Gen name	Trade name	Catagory name
finasteride	Propecia	5-alpha-reductase inhibitors
finasteride	Proscar	5-alpha-reductase inhibitors
Finasteride	FINASID 5MG FILM COATED TABLET
Finasteride	FINISCAR 5MG FC TABLETS
Finasteride	PROHAIR
Finasteride	PROPECIA
Finasteride	PROSCAR
Finasteride	PROSNORM
Finasteride	PROSTID 5MG FC TABLETS

Gen name	trade name	catogry
dutasteride	Avodart	5-alpha-reductase inhibitors
finasteride	Propecia	5-alpha-reductase inhibitors
dutasteride / tamsulosin	Jalyn	5-alpha-reductase inhibitors
finasteride	Proscar	5-alpha-reductase inhibitors