Amlodipine is a vasodilator drug belonging to the family of calcium channel blockers, used to treat patients with??high blood pressure and??angina pectoris. Because it belongs to the family of calcium blockers, amlodipine affects the signal transduction process in the heart muscle and in the blood vessels.
Like other calcium blockers, amlodipine may cause a very severe drop in blood pressure, although this is a rare phenomenon. Common side effects include fluid accumulation, edema, and headache.

Category

Chemical class: Dihydropyridine
Therapeutic class: Antianginal, antihypertensive

Pregnancy category: C

Indications

To control hypertension
Adults.Initial: 5 mg daily, increased gradually over 10 to 14 days, as needed. Maximum: 10 mg daily.
DOSAGE ADJUSTMENT Initially 2.5 mg daily for elderly patients or patients with impaired hepatic function. Increased gradually over 7 to 14 days based on response. To treat chronic stable angina and Prinzmetal’s (variant) angina
Adults.5 to 10 mg daily.
DOSAGE ADJUSTMENT 5 mg daily for elderly patients and those with impaired hepatic function. Route Onset Peak Duration P.O. Unknown 6–12 hr 24 hr

Mechanism of Action

Binds to dihydropyridine and nondihydropyridine cell membrane receptor sites on myocardial and vascular smooth-muscle cells and inhibits influx of extracellular calcium ions across slow calcium channels. This decreases intracellular calcium level, inhibiting smooth-muscle cell contractions and relaxing coronary and vascular smooth muscles, decreasing peripheral vascular resistance, and reducing systolic and diastolic blood pressure. Decreased peripheral vascular resistance also decreases myocardial workload, oxygen demand, and possibly angina. Also, by inhibiting coronary artery muscle cell contractions and restoring blood flow, drug may relieve Prinzmetal’s angina.

Contraindications

Hypersensitivity to amlodipine or its components

Interactions

beta blockers: Possibly excessive hypotension fentanyl: Increased risk of severe hypotension and increased fluid volume requirements during surgery

Side Efect

CNS: Anxiety, dizziness, fatigue, headache, lethargy, light-headedness, paresthesia, somnolence, syncope, tremor
CV: Arrhythmias, hypotension, palpitations, peripheral edema
EENT: Dry mouth, pharyngitis
ENDO: Hot flashes
GI: Abdominal cramps, abdominal pain, constipation, diarrhea, esophagitis, indigestion, nausea amlodipine besylate 70
GU: Decreased libido, impotence, urinary frequency
MS: Myalgia
RESP: Dyspnea
SKIN: Dermatitis, flushing, rash
Other: Weight loss

Cautions

Use amlodipine cautiously in patients with heart block, heart failure, impaired renal function, hepatic disorder, or severe aortic stenosis.

Monitor blood pressure while adjusting dosage, especially in patients with heart failure or severe aortic stenosis.

PATIENT SAFTY

Tell patient to take missed dose as soon as remembered and next dose in 24 hours.

Tell patient to immediately notify prescriber of dizziness, arm or leg swelling, difficulty breathing, hives, or rash.

Suggest taking amlodipine with food to reduce GI upset.

Advise patient to routinely have blood pressure checked for possible hypotension.

Trade Name & Company Name

Trade name	Company name
LOWVASC 5MG CAPSULE	ADVANCED PHARMACEUTICAL INDUSTRIES
AMLOCARD 5MG TABLETS	BATTERJEE PHARMACETICAL FACTORY
AMLODAR 10MG CAPSULES	DAR ALDAWA
CADUET 10-10	GOEDECKE
CADUET 10-20	GOEDECKE
AMLOPHAR 5MG CAPSULES	Gulf Pharmaceutical Industries (Julphar)
VASCODIPINE	RIYADH PHARMA
AMLOPRESS 5MG CAPSULES	SAJA-SAUDI ARABIAN JAPANESE PHARMACEUTICAL CO
LOTENSE 10MG CAPSULES	TABUK PHARMACEUTICAL MANUFACTURING CO.
AMLOR 10MG CAPSULES	Hikma

effect of Amlodipine in Pregnancy, Fetal Health and Breast feeding

Pregnancy

. There are no well-controlled studies in women of amlodipine during pregnancy. Other calcium channel antagonists are used as inhibitors of myometrial contraction, and amlodipine has similar properties. There are no reports of its use as a tocolytic agent.

Fetal Health

There are no adequate reports or well-controlled studies in human fetuses. It is unknown whether amlodipine crosses the human placenta. Rodent studies are reassuring, revealing no evidence of teratogenicity or IUGR despite the use of doses 8- 23the MRHD.

Breastfeeding

There is no published experience in nursing women. It is unknown whether amlodipine enters human breast milk.

the follwing drugs will increse Amlodipine by inhepiting cyp450

amiodarone ; amiodarone ; aprepitant ; aprepitant ; atomoxetine ; atomoxetine ; boceprevir ; boceprevir ; ceritinib ; ceritinib ; chloramphenicol ; chloramphenicol ; cimetidine ; cimetidine ; ciprofloxacin ; ciprofloxacin ; clarithromycin ; clarithromycin ; crizotinib ; crizotinib ; delaviridine ; delaviridine ; diethyl-dithiocarbamate ; diethyl-dithiocarbamate ; diltiazem ; diltiazem ; entrectinib ; entrectinib ; erythromycin ; erythromycin ; esomeprazole ; esomeprazole ; fluconazole ; fluconazole ; fluvoxamine ; fluvoxamine ; gestodene ; gestodene ; grapefruit juice ; grapefruit juice ; idelalisib ; idelalisib ; imatinib ; imatinib ; indinavir ; indinavir ; itraconazole ; itraconazole ; ivacaftor ; ivacaftor ; ketoconazole ; ketoconazole ; lesinurad ; lesinurad ; letermovir ; letermovir ; mibefradil ; mibefradil ; mifepristone ; mifepristone ; nefazodone ; nefazodone ; nelfinavir ; nelfinavir ; netupitant/palonosetron ; netupitant/palonosetron ; norfloxacin ; norfloxacin ; norfluoxetine ; norfluoxetine ; omeprazole ; omeprazole ; pantoprazole ; pantoprazole ; perampanel ; perampanel ; quercetin ; quercetin ; regorafenib ; regorafenib ; ribociclib ; ribociclib ; ritonavir ; ritonavir ; rucaparib ; rucaparib ; saquinavir ; saquinavir ; simeprevir ; simeprevir ; starfruit ; starfruit ; telaprevir ; telaprevir ; telithromycin ; telithromycin ; ticagrelor ; ticagrelor ; tucatinib ; tucatinib ; verapamil ; verapamil ; voriconazole ; voriconazole ;

the follwing drugs will decrease Amlodipine by inhancing cyp450

barbiturates ; barbiturates ; brigatinib ; brigatinib ; carbamazepine ; carbamazepine ; clobazam ; clobazam ; dabrafenib ; dabrafenib ; efavirenz ; efavirenz ; elagolix ; elagolix ; enzalutamide ; enzalutamide ; eslicarbazepine ; eslicarbazepine ; glucocorticoids ; glucocorticoids ; letermovir ; letermovir ; lorlatinib ; lorlatinib ; modafinil ; modafinil ; nevirapine ; nevirapine ; oxcarbazepine ; oxcarbazepine ; perampanel ; perampanel ; phenobarbital ; phenobarbital ; phenytoin ; phenytoin ; pioglitazone ; pioglitazone ; rifabutin ; rifabutin ; rifampin ; rifampin ; St. John's Wort ; St. John's Wort ; telotristat ; telotristat ; troglitazone ; troglitazone ; vemurafenib ; vemurafenib ;

Calcium channel blocking agents

...
ACE inhibitors with calcium channel blocking agents

...
Cox-2 inhibitors

...
Miscellaneous antihypertensive combinations

...
Antihypertensive

...
Cardiovascular Agent

...
Calcium Channel Blocker

...

Gen name	Trade name	Catagory name
aliskiren / amlodipine	Tekamlo	Miscellaneous antihypertensive combinations
aliskiren / amlodipine / hydrochlorothiazide	Amturnide	Miscellaneous antihypertensive combinations
amlodipine	Katerzia	Calcium channel blocking agents
amlodipine	Norliqva	Calcium channel blocking agents
amlodipine	Norvasc	Calcium channel blocking agents
amlodipine / atorvastatin	Caduet	Miscellaneous antihypertensive combinations
amlodipine / benazepril	Amlobenz	ACE inhibitors with calcium channel blocking agents
amlodipine / benazepril	Lotrel	ACE inhibitors with calcium channel blocking agents
amlodipine / celecoxib	Consensi	Cox-2 inhibitors
amlodipine / celecoxib	Consensi	Miscellaneous antihypertensive combinations
amlodipine / hydrochlorothiazide / olmesartan	Tribenzor	Miscellaneous antihypertensive combinations
amlodipine / hydrochlorothiazide / valsartan	Exforge HCT	Miscellaneous antihypertensive combinations
amlodipine / perindopril	Prestalia	ACE inhibitors with calcium channel blocking agents
levamlodipine	Conjupri	Calcium channel blocking agents
Amlodipine	AMLOCARD 5MG TABLETS
Amlodipine	AMLODAR 10MG CAPSULES
Amlodipine	AMLOPHAR 5MG CAPSULES
Amlodipine	AMLOPRESS 5MG CAPSULES
Amlodipine	AMLOR 10MG CAPSULES
Amlodipine	CADUET 10-10
Amlodipine	CADUET 10-20
Amlodipine	LOTENSE 10MG CAPSULES
Amlodipine	LOWVASC 5MG CAPSULE
Amlodipine	VASCODIPINE

Gen name	trade name	catogry
amlodipine / hydrochlorothiazide / olmesartan	Tribenzor	Miscellaneous antihypertensive combinations
aliskiren/valsartan	Valturna	Miscellaneous antihypertensive combinations
amlodipine / hydrochlorothiazide / valsartan	Exforge HCT	Miscellaneous antihypertensive combinations
aliskiren / hydrochlorothiazide	Tekturna HCT	Miscellaneous antihypertensive combinations
amlodipine / celecoxib	Consensi	Miscellaneous antihypertensive combinations
amlodipine / atorvastatin	Caduet	Miscellaneous antihypertensive combinations
hydralazine / isosorbide dinitrate	BiDil	Miscellaneous antihypertensive combinations
aliskiren / amlodipine	Tekamlo	Miscellaneous antihypertensive combinations
hydralazine / hydrochlorothiazide / reserpine	Ser-Ap-Es	Miscellaneous antihypertensive combinations
nebivolol / valsartan	Byvalson	Miscellaneous antihypertensive combinations
hydralazine / hydrochlorothiazide	Apresazide	Miscellaneous antihypertensive combinations
aliskiren / amlodipine / hydrochlorothiazide	Amturnide	Miscellaneous antihypertensive combinations
celecoxib	Celebrex	Cox-2 inhibitors
rofecoxib	Vioxx	Cox-2 inhibitors
valdecoxib	Bextra	Cox-2 inhibitors
amlodipine / celecoxib	Consensi	Cox-2 inhibitors
celecoxib	Elyxyb	Cox-2 inhibitors
amlodipine	Norvasc	Calcium channel blocking agents
diltiazem	Cartia XT	Calcium channel blocking agents
diltiazem	Cardizem	Calcium channel blocking agents
verapamil	Calan SR	Calcium channel blocking agents
diltiazem	Cardizem CD	Calcium channel blocking agents
nifedipine	Adalat	Calcium channel blocking agents
nifedipine	Procardia	Calcium channel blocking agents
nifedipine	Nifedical XL	Calcium channel blocking agents
verapamil	Calan	Calcium channel blocking agents
verapamil	Verelan PM	Calcium channel blocking agents
diltiazem	Tiazac	Calcium channel blocking agents
nifedipine	Procardia XL	Calcium channel blocking agents
verapamil	Isoptin SR	Calcium channel blocking agents
diltiazem	Dilt-XR	Calcium channel blocking agents
verapamil	Verelan	Calcium channel blocking agents
nisoldipine	Sular	Calcium channel blocking agents
felodipine	Plendil	Calcium channel blocking agents
nimodipine	Nimotop	Calcium channel blocking agents
diltiazem	Cardizem LA	Calcium channel blocking agents
nifedipine	Adalat CC	Calcium channel blocking agents
diltiazem	Taztia XT	Calcium channel blocking agents
nifedipine	Nifediac CC	Calcium channel blocking agents
isradipine	DynaCirc CR	Calcium channel blocking agents
diltiazem	Dilacor XR	Calcium channel blocking agents
verapamil 1 review	Covera-HS	Calcium channel blocking agents
nimodipine	Nymalize	Calcium channel blocking agents
diltiazem	Matzim LA	Calcium channel blocking agents
isradipine	Dynacirc	Calcium channel blocking agents
diltiazem	Diltia XT	Calcium channel blocking agents
levamlodipine	Conjupri	Calcium channel blocking agents
nicardipine	Cardene SR	Calcium channel blocking agents
nicardipine	Cardene IV	Calcium channel blocking agents
nifedipine	Afeditab CR	Calcium channel blocking agents
diltiazem	Tiadylt ER	Calcium channel blocking agents
amlodipine	Norliqva	Calcium channel blocking agents
amlodipine	Katerzia	Calcium channel blocking agents
diltiazem	Diltzac	Calcium channel blocking agents
clevidipine	Cleviprex	Calcium channel blocking agents
nicardipine	Cardene	Calcium channel blocking agents
amlodipine / benazepril	Lotrel	ACE inhibitors with calcium channel blocking agents
trandolapril / verapamil	Tarka	ACE inhibitors with calcium channel blocking agents
amlodipine / perindopril	Prestalia	ACE inhibitors with calcium channel blocking agents
amlodipine / benazepril	Amlobenz	ACE inhibitors with calcium channel blocking agents
enalapril/felodipine	Lexxel	ACE inhibitors with calcium channel blocking agents