PHENYTOIN

Brand Name & Strength

Dilantin 250 mg/5 ml

Reconstitution

Not required

Further Dilution

IV infusion

Dilute dosage required in 50 – 100 ml diluent (maximum concentration: 10 mg/ml)

Diluent

NS

Administration & Infusion rate

IV infusion

Administer over 1 hr Do not exceed dose of 50 mg/min in adults and not to exceed 1 – 3 mg/kg/min in neonates and children Slow IV Administer slowly, not exceeding 50 mg/min in adults

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

Stable as long as free of haziness and precipitate -

Remarks

Avoid IM administration due to severe risk of local tissue destruction and necrosis; use Fosphenytoin if IM administration necessary The manufacturer’s labelling includes IM administration; however, in general the IM route should be avoided and should not be used for status epilepticus