AMIODARONE

Brand Name & Strength

Cordarone 150 mg/3 ml

Reconstitution

Not required

Further Dilution

Minimum concentration: 300 mg/500 ml [5] Arrhythmias

Loading dose: 5 mg/kg (150 mg – 300 mg) in 100 ml diluent [1,2].

Maintenance dose: 10 – 20 mg/kg/day (max: 1.2 g) in 250 – 500 [3,4] ml diluent Ventricular fibrillation or pulseless ventricular tachycardia

Loading dose: 5 mg/kg (300 mg) diluted in 20 ml diluent. Add 2.5 mg/kg (150 mg) if necessary,

Followed by 900 mg in 500 ml over 24 hr

Diluent

D5

Administration & Infusion rate

Arrhythmias[5]

Loading dose: Administer by

IV infusion

over 20 min to 2 hr [5]

Maintenance dose: Administer over 24 hr. Ventricular fibrillation or pulseless ventricular tachycardia [5]

Loading dose: Administer by

IV bolus

[5]

Followed by

IV infusion

over 24 hr.

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

Use immediately [1,3] -

Remarks

Drug levels above 3 mg/ml in D5 has been linked to high incidence of peripheral vein phlebitis; levels of 2.5 mg/ml or lower are less irritating. Therefore, for infusions longer than 1 hour, do not exceed concentrations of more than 2 mg/ml, unless using central venous catheter.