CEFOPERAZONE

Brand Name & Strength

Bicafar 500 mg, 1000 mg, 2000 mg

Reconstitution

Reconstitute with 5 ml of D5, NS, D10, WFI

Further Dilution

Slow IV

Dilute reconstituted solution with 20 – 100 ml diluent

IV infusion

Dilute the reconstituted solution with 20 – 100 ml diluent IM

WFI should be used when preparing Cefoperazone. However, when concentration of more than 250 mg/ml a lidocaine solution should be used

Diluent

NS, D5, D10, lactated Ringer’s solution

Administration & Infusion rate

IV infusion

Administer over 15 min – 1 hr Slow IV

Administer over 3 – 5 min IM

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

24 hr 5 days

After dilution

Remarks

Cefoperazone is incompatible with aminoglycosides, perphenazine or pethidine hydrochloride

When given by IM, inject into large muscle mass of gluteus maximum or anterior thigh