AMINOPHYLLINE

Brand Name & Strength

DBL Aminophylline Injection 250 mg/10 ml

Reconstitution

Not required

Further Dilution

Loading dose

IV infusion

Up to 250 mg: dilute in 50 ml diluent

250 – 500 mg: dilute in 100 ml diluent Maintenance dose

Continuous IV infusion

250 – 500 mg in 500 ml diluent

Diluent

D5, NS

Administration & Infusion rate

Loading dose IV infusion

Administer over 20 – 30 min Maintenance dose

Continuous IV infusion

Administer at a rate of 0.5 mg/kg/hr. Dose must be individualised based on patient characteristics, clinical response, and steady state theophylline concentration. Rate of administration not to exceed 20 – 25 mg/min

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

- -

Remarks

IM administration not recommended

Obtain serum drug level 20 – 30 min after starting continuous infusion

Rapid administration may cause arrhythmia

In patients with cor pulmonale, cardiac decompensation, or hepatic dysfunction and in those taking drugs that markedly reduce theophylline clearance, do not exceed initial infusion rate of 21 mg/hr

Flumazenil

Fluorescein

Flupentixol

Fluphenazine Decanoate

Fondaparinux

Foscarnet

Frusemide

Ganciclovir Sodium

Gentamicin

Glucagon