AMINOPHYLLINE

AMINOPHYLLINE

Brand Name & Strength

DBL Aminophylline Injection 250 mg/10 ml

Reconstitution

Not required

Further Dilution

Loading dose
  • IV infusion

  • Up to 250 mg: dilute in 50 ml diluent
  • 250 – 500 mg: dilute in 100 ml diluent Maintenance dose
  • Continuous IV infusion
  • 250 – 500 mg in 500 ml diluent

    Diluent

    D5, NS

    Administration & Infusion rate

  • Loading dose IV infusion

  • Administer over 20 – 30 min Maintenance dose

    Continuous IV infusion

  • Administer at a rate of 0.5 mg/kg/hr. Dose must be individualised based on patient characteristics, clinical response, and steady state theophylline concentration. Rate of administration not to exceed 20 – 25 mg/min

    Storage & Stability

    RT

    (<25 oC)

    Fridge

    (2 – 8 oC)

    After Reconstitution

    - -

    After dilution

    - -

    Remarks

  • IM administration not recommended
  • Obtain serum drug level 20 – 30 min after starting continuous infusion
  • Rapid administration may cause arrhythmia
  • In patients with cor pulmonale, cardiac decompensation, or hepatic dysfunction and in those taking drugs that markedly reduce theophylline clearance, do not exceed initial infusion rate of 21 mg/hr