CEFOTAXIME

CEFOTAXIME

Brand Name & Strength

Rekaxime 500 mg & 1000 mg Injection, Cefotaxime 1 g Injection

Reconstitution

Reconstitute 500 mg vial with 2 ml of WFI or 1000 mg vial with 4 ml of diluent

Further Dilution

IV infusion

  • Dilute in 40 – 100 ml diluent

    Diluent

    WFI, NS, D5 [1,2], D10 (for short infusion), NSD5 , HS, lactated Ringer’s solution

    Administration & Infusion rate

    IV bolus

  • Administer over 3 – 5 min

    IV infusion

  • Administer over 20 – 60 min IM
  • Inject deep into the gluteus muscle

    Storage & Stability

    RT

    (<25 oC)

    Fridge

    (2 – 8 oC)

    After Reconstitution

    24 hr 10 days (< 5 oC)

    After dilution

    24 hr 5 days

    Remarks

  • Do not use diluents with pH above 7.5 (eg. Sodium Bicarbonate)[1,2,3]
  • Doses given over less than 1 min have caused life threatening arrhythmias
  • If daily dose exceeds 2 g of cefotaxime, IV injection is to be preferred
  • Incompatible with hetastarch sodium chloride