CEFOTAXIME

Brand Name & Strength

Rekaxime 500 mg & 1000 mg Injection, Cefotaxime 1 g Injection

Reconstitution

Reconstitute 500 mg vial with 2 ml of WFI or 1000 mg vial with 4 ml of diluent

Further Dilution

IV infusion

Dilute in 40 – 100 ml diluent

Diluent

WFI, NS, D5 [1,2], D10 (for short infusion), NSD5 , HS, lactated Ringer’s solution

Administration & Infusion rate

IV bolus

Administer over 3 – 5 min

IV infusion

Administer over 20 – 60 min IM

Inject deep into the gluteus muscle

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

24 hr 10 days (< 5 oC)

After dilution

24 hr 5 days

Remarks

Do not use diluents with pH above 7.5 (eg. Sodium Bicarbonate)[1,2,3]

Doses given over less than 1 min have caused life threatening arrhythmias

If daily dose exceeds 2 g of cefotaxime, IV injection is to be preferred

Incompatible with hetastarch sodium chloride