ACYCLOVIR

Brand Name & Strength

Zovirax® 250 mg/10 ml, Vaxcel Acyclovir 250 mg

Reconstitution

Reconstitute with 10 ml WFI or NS

Further Dilution

Dilute 250 – 500 mg with 100 ml of diluent (concentration: 2.5 – 5 mg/ml)

Diluent

NS, Hartmann’s Solution, Sodium Chloride 0.45% w/v and Glucose 4% w/v [1,2,4]

Administration & Infusion rate

IV infusion

Administer over 1 hr

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

12 hr [2,3], 48 hr -

After dilution

24 hr [2,3], 48 hr -

Remarks

Do not give by

IV bolus

, IM or SC

Administer

IV infusion

at a constant rate over at least 1 hr using infusion pump or micro drip

Infusion concentration of 7 mg/ml or lower are recommended. Higher concentration of > 10 mg/ml increases the risk of phlebitis [2,3]

Refrigerating reconstituted solutions may cause precipitation (which redissolves at

RT