ACYCLOVIR

ACYCLOVIR

Brand Name & Strength

Zovirax® 250 mg/10 ml, Vaxcel Acyclovir 250 mg

Reconstitution

Reconstitute with 10 ml WFI or NS

Further Dilution

Dilute 250 – 500 mg with 100 ml of diluent (concentration: 2.5 – 5 mg/ml)

Diluent

NS, Hartmann’s Solution, Sodium Chloride 0.45% w/v and Glucose 4% w/v [1,2,4]

Administration & Infusion rate

IV infusion

  • Administer over 1 hr

    Storage & Stability

    RT

    (<25 oC)

    Fridge

    (2 – 8 oC)

    After Reconstitution

    12 hr [2,3], 48 hr -

    After dilution

    24 hr [2,3], 48 hr -

    Remarks

  • Do not give by

    IV bolus

    , IM or SC
  • Administer

    IV infusion

    at a constant rate over at least 1 hr using infusion pump or micro drip
  • Infusion concentration of 7 mg/ml or lower are recommended. Higher concentration of > 10 mg/ml increases the risk of phlebitis [2,3]
  • Refrigerating reconstituted solutions may cause precipitation (which redissolves at

    RT