PETHIDINE

Brand Name & Strength

Pethidine Injection 50 mg/ml & 100 mg/2 ml

Reconstitution

Not required

Further Dilution

Slow IV Use undiluted, or preferably dilute with 5 ml diluent

IV infusion

Dilute each 10 mg in 1 ml diluent (concentration: 10 mg/ml)

Diluent

NS, D5, D10, lactated Ringer’s solution

Administration & Infusion rate

Slow IV

IV infusion

Administer at 15 – 35 mg/hr (as required) IM, SC

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

- -

Remarks

Ensure patient is lying down during IV administration Rapid I.V. injection increases risk of serious adverse reactions (such as severe respiratory depression, apnea, hypotension, peripheral circulatory, collapse, and cardiac arrest).