VANCOMYCIN

Brand Name & Strength

DBLTM Vancomycin Hydrochloride 500 mg, Vancomycin Lyomark 50 mg/ml

Reconstitution

Reconstitute 1 vial with 10 ml WFI (concentration: 50 mg/ml)

Further Dilution

IV infusion

Dilute with 100 ml of diluent For fluid restricted patients concentration of up to 10 mg/ml may be used Continuous

IV infusion

Dilute with 250 ml of diluent

Diluent

NS, D5

Administration & Infusion rate

IV infusion

Administer 500 mg over at least 60 min Administer 1 g over at least 2 hr Continuous

IV infusion

Administer over 12 hr. The total daily dose should be split into two and the infusion rate set at 20.8 mg/hr Oral Administer 500 mg in 30 ml of distilled water

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- 96 hr , 48 hr

After dilution

24 hr Not more than 24 hr

Remarks

Recommended infusion period of ≥ 30 min for every 500 mg administered Not for IM administration Rapid IV administration (eg. over less than 60 min) may result in hypotension, flushing, erythema, urticaria, pruritus and rarely cardiac arrest. -