NALOXONE

Brand Name & Strength

Mapin 0.4 mg/ml

Reconstitution

Not required

Further Dilution

IV bolus

Use undiluted or dilute 0.4 mg (1 ampoule) with 9 ml diluent to a total volume of 10 ml (40 mcg/ml)

IV infusion

Dilute 2 mg (5 ampoules) in 500 ml of diluent (4 mcg/ml)

Diluent

NS, D5

Administration & Infusion rate

IV bolus

Administer doses of 0.4 mg or less (undiluted) by direct injection over 15 sec or 30 sec

IV infusion

As prescribed by doctor, titrated based on patient’s response. IM, SC

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

24 hr -

Remarks

The most rapid onset is achieved by IV administration and is recommended in emergency situations.