BELIMUMAB

Brand Name & Strength

Benlysta ® 80 mg/ml (120 mg/vial or 400 mg/vial)

Reconstitution

Volume of WFI Concentration (mg/ml)

Allow the powder vial to stand at room temperature for 10 – 15 min

During reconstitution, gently swirls the vial for 60 seconds every 5 min until the powder is dissolved.

Reconstitution

is typically complete within 10 – 15 min, or up to 30 min.

Further Dilution

Dilute to 250 ml diluent

Diluent

NS

Administration & Infusion rate

IV infusion

Administer over 1 hour [1,2,3]

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

8 hr

Remarks

Must not administered as IV push or bolus

D5 is incompatible and should not be used

Protect from sun light. Should not infused concomitantly with other agents

Premedicating with antihistamine and antipyretic can be considered as prophylaxis against hypersensitivity or infusion reactions.