DOBUTAMINE

DOBUTAMINE

Brand Name & Strength

Mobitil injection 250 mg/20 ml

Reconstitution

Not required

Further Dilution

Dilute to at least 50 ml diluent (maximum concentration: 10 mg/ml)
  • Dilute 250 mg Dobutamine in 50 ml diluent (concentration: 5 mg/ml)
  • Dilute 500 mg Dobutamine in 50 ml diluent (concentration: 10 mg/ml)

    Diluent

    NS, D5, NSD5, HSD5, D10, D5 in lactated Ringer’s Calculation Eg. Doctor ordered IV Dobutamine 2.5 mcg/kg/min. Patient’s weight is 70 kg. What is the infusion rate? 1. Determine dose (mg/hr) = Dose (mcg/kg/min) x BW (kg) x 60 min/hr 1000 mcg/mg = 2.5 x 70 x 60 = 10.5 mg/hr 1000 2. Determine concentration (mg/ml) = 5 mg/ml (if dilute 250 mg in 50 ml diluent) 3. Calculate infusion rate (ml/hr) = Dose (mg/hr) = 10.5 = 2.1 ml/hr Concentration (mg/ml) 5

    Administration & Infusion rate

    Continuous

    IV infusion

  • Dose: 2.5 – 10 mcg/kg/min; frequently doses up to 20 mcg/kg/min (max: 40 mcg/kg/min)
  • Rate of infusion: As per calculation above

    Storage & Stability

    RT

    (<30 oC)

    Fridge

    (2-8 oC)

    After Reconstitution

    - -

    After dilution

    24 hr -

    Remarks

  • Incompatible with sodium bicarbonate injection or any other strongly alkaline solutions.
  • Solution may exhibit pink colour (if present, will increase with time). The colour change is due to slight oxidation of drug but there is no significant loss of potency.