DOPAMINE

DOPAMINE

Brand Name & Strength

Loxin Injection 200 mg/5 ml

Reconstitution

Not required

Further Dilution

Dilute to 250 – 500 ml diluent, to give final concentration as such:
  • 250 ml dilution: 800 mcg/ml of Dopamine (0.8 mg/ml)
  • 500 ml dilution: 400 mcg/ml of Dopamine (0.4 mg/ml) Minimal dilution:
  • Single strength: Dilute 200 mg with 50 ml of NS or D5 (4 mg/ml)
  • Double strength: Dilute 400 mg with 50 ml of NS or D5 (8 mg/ml)
  • For patients with fluid retention: Dilute 200 mg in 50 ml (concentration: 4 mg/ml)

    Diluent

    NS, D5, NSD5, HSD5, lactated Ringer’s solution, sodium lactate solution (1/6 molar)

    Administration & Infusion rate

    Continuous

    IV infusion

  • Dose: 2.5 mcg/kg/min; max dose 20 mcg/kg/min
  • Rate of infusion: As per calculation above

    Storage & Stability

    RT

    (<25 oC)

    Fridge

    (2 – 8 oC)

    After Reconstitution

    - -

    After dilution

    24 hr

    Remarks

  • Administer into central line
  • Incompatible with sodium bicarbonate or other alkaline solutions as this inactivates drug [2,3]
  • Loading dose or bolus injection are not recommended