DOPAMINE

Brand Name & Strength

Loxin Injection 200 mg/5 ml

Reconstitution

Not required

Further Dilution

Dilute to 250 – 500 ml diluent, to give final concentration as such:

250 ml dilution: 800 mcg/ml of Dopamine (0.8 mg/ml)

500 ml dilution: 400 mcg/ml of Dopamine (0.4 mg/ml) Minimal dilution:

Single strength: Dilute 200 mg with 50 ml of NS or D5 (4 mg/ml)

Double strength: Dilute 400 mg with 50 ml of NS or D5 (8 mg/ml)

For patients with fluid retention: Dilute 200 mg in 50 ml (concentration: 4 mg/ml)

Diluent

NS, D5, NSD5, HSD5, lactated Ringer’s solution, sodium lactate solution (1/6 molar)

Administration & Infusion rate

Continuous

IV infusion

Dose: 2.5 mcg/kg/min; max dose 20 mcg/kg/min

Rate of infusion: As per calculation above

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

24 hr

Remarks

Administer into central line

Incompatible with sodium bicarbonate or other alkaline solutions as this inactivates drug [2,3]

Loading dose or bolus injection are not recommended