STREPTOKINASE

Brand Name & Strength

Streptase ® 1.5 MIU/vial

Reconstitution

Reconstitute with 5 ml of NS or D5

Further Dilution

Dilute reconstituted solution (1,500,000 IU) with 50 – 250 ml of diluent or with 150 ml D5 (10,000 IU/ml)

Diluent

NS, D5, lactated Ringer’s solution, laevulose solution

Administration & Infusion rate

IV, Intraarterially Acute evolving transmural myocardial infarction: 1.5 MIU over 1 hr Pulmonary embolus: Loading dose 250,000 IU over 30 min followed by 100,000 IU/hr for 24 hr

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

Use immediately 24 hr

After dilution

- -

Remarks

Give test dose of 100 IU and wait for 20 minutes to check for hypersensitivity Infusion should be performed slowly at the beginning of therapy as fall in blood pressure, increase/decrease in heart rate are commonly observed Do not use drop-counting infusion methods, since drug may alter drop size Reconstituted solution can be filtered through 0.8-micron filter