DIGOXIN

Brand Name & Strength

Lanoxin Injection 500 mcg/2 ml

Reconstitution

Not required

Further Dilution

IV infusion

Dilute with a 4-fold or greater volume of diluent. Max concentration is 62.5 mcg/ml

Dilute 1 ampule (0.5 mg) in 50 ml diluent

Diluent

NS, D5

Administration & Infusion rate

Slow IV

Administer over 5 min or longer (undiluted)

IV infusion

Administer over 10 – 20 min

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

48 hr -

Remarks

Dilution with less than 4 fold of volume of diluent could lead to precipitation of Digoxin

Rapid injection is not recommended as it may cause systemic and coronary arteriolar constriction

Intramuscular route is not recommended as it is painful and associated with muscle necrosis.