FILGRASTIM

Brand Name & Strength

Neupogen 300 mcg/1 ml (vial), Neupogen 300 mcg/0.5 ml (prefilled syringe)

Reconstitution

Not required

Further Dilution

IV infusion

, Continuous

IV infusion

Dilute with diluent to a final concentration of ≥ 5 mcg/ml

Diluent

D5

Administration & Infusion rate

SC

Administer undiluted

IV infusion

Administer over 15 – 30 min Continuous

IV infusion

Administer over 4 – 24 hr

Storage & Stability

RT

(<25 oC)

Fridge

(2-8 oC)

After Reconstitution

- -

After dilution

Use immediately 24 hours

Remarks

Avoid vigorous shaking

Do not use pre-filled syringe for IV preparation

Dilute in normal saline may cause precipitation [2,3]

For patients treated with Neupogen diluted to concentration below 15 mcg/ml, human albumin should be added to a final concentration of 2 mg/ml

Example: In a final injection volume of 20 ml, total dose of Neupogen less than 300 mcg should be given with 0.2 ml of 20% human albumin