DESFERRIOXAMINE

Brand Name & Strength

Desferal® 500mg

Reconstitution

Strength 500mg

Further Dilution

IV infusion

, Continuous

IV infusion

Dilute with 150 ml diluent

Diluent

NS, D5, Ringer’s solution, lactated Ringer’s solution [1,3], peritoneal dialysis solutions such as Dianeal 137 Glucose 2.27%, Dianeal PD4 Glucose 2.27% and CAPD/DPCA 2 Glucose 1.5%

Administration & Infusion rate

Chronic iron overload

SC infusion

Administer by portable infusion pump over 8 – 12 hr or 24 hr [1,2,3]

IV infusion

Administer over 8 – 12 hr, rate not to exceed 15 mg/kg/hr. May administer longer infusion times (24 hr) in patient with severe cardiac iron deposition. [2,3]

For patients not tolerating SC infusion

IM

When SC infusion is not feasible but IV route is preferred Acute iron poisoning

Continuous

IV infusion

Administer at a rate of 15 mg/kg/hr, reduce as soon as circumstances permit usually after 4 – 6 hr. (max total IV dose: 80 mg/kg/24hr) Chronic aluminium overload in ESRF

Slow

IV infusion

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

Use immediately -

After dilution

- -

Remarks

Do not administer concurrently with blood transfusion [2,3]

IV route is preferred in patients with severe toxicity (ie, patients in shock)