ISOPRENALINE

Brand Name & Strength

Isuprel™ 0.2 mg/ml, 1 mg/5 ml, Isoprenaline Hydrochloride Monico 0.2 mg/1 ml

Reconstitution

Not required

Further Dilution

IM, SC, Intracardiac

No further dilution required

IV bolus

Dilute 1 ml with 10 ml diluent

IV infusion

Adults with shock and hypo perfusion states:

Dilute 5 ml (1 mg) in 500 ml of D5. Concentration up to 10x greater have been used when limitation of volume is essential

Adults with heart block, Adams-Stokes attacks and cardiac arrest:

Dilute 10 ml (2 mg) in 500 ml of diluent

Diluent

D5, NS

Administration & Infusion rate

IM, SC, Intracardiac

IV bolus

Adults with heart block, Adams-Stokes attacks and cardiac arrest:

Administer 0.02 – 0.06 mg (1 – 3 ml of diluted solution)

Subsequent administration: 0.01 – 0.2 mg (0.5 – 10 ml of diluted solution)

Bronchospasm occurring during anaesthesia:

Administer 0.01 – 0.02 mg (0.5 – 1 ml of diluted solution)

Dose may be repeated when necessary

IV infusion

Adults with shock and hypo perfusion states:

Administer at 0.5 – 5 mcg/min (0.25 – 2.5 ml of diluted solution)

Rates over 30 mcg/min have been used in advanced stages of shock. Rate should be adjusted based on heart rate, central venous pressure, systemic blood pressure and urine flow. If heart rate > 110 bpm, it may be advisable to decrease or temporarily discontinue the infusion.

Adults with heart block, Adams-Stokes attacks and cardiac arrest:

Rate: Administer at 5 mcg/min. (1.25 ml of diluted solution per min) HAM

Storage & Stability

RT

(<25 oC)

Fridge

(2-8 oC)

After Reconstitution

- -

After dilution

- -

Remarks

The usual route of administration is by

IV infusion

or

IV bolus

injection. In dire emergencies, the drug may be administered by intracardiac injection. If time is not of the utmost importance, initial therapy by IM or SC injection is preferred