OXYTOCIN

OXYTOCIN

Brand Name & Strength

Udoxan Injection 10 IU/ml

Reconstitution

Not required

Further Dilution

IV infusion

Induction and Enhancement of Labour Dilute 10 IU to 1000 ml diluent to yield Oxytocin 0.01 IU/ml (10 mIU/ml) Postpartum uterine bleeding Dilute 10 – 40 IU to running

IV infusion

, max: 40 IU/1000 ml

Diluent

NS [1,2,3,4], or lactated Ringer’s solution

Administration & Infusion rate

IV infusion

For induction and enhancement of labour Administer at 1 – 4 mIU/min (0.1 – 0.4 ml/min or 2 – 8 drops/min). Increase rate gradually at intervals of not shorter than 20 min. Max rate: 20 mIU/min (2 ml/min or 40 drops/min) For postpartum bleeding Administer 10 – 40 IU at a rate sufficient to sustain uterine contraction and control uterine atony. IM Administer 10 IU after delivery

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

- -

Remarks

IV bolus

for more than 2 I.U can cause acute hypotension Use of D5 is not recommended. Not compatible with solutions containing bisulphites and metasulphites as preservatives Do not exceed 30 IU in 12-hr period because of risk of water intoxication