CLOXACILLIN
Brand Name & Strength
Cloxacillin Sodium 250mg & 500mg
Reconstitution
IM
250mg reconstitute with 1.9 ml WFI (to make 2.0 ml 125 mg/ml solution)
500mg reconstitute with 1.7 ml WFI (to make 2.0 ml 250 mg/ml solution)
IV
250mg reconstitute with 4.9 ml WFI (to make 5.0 ml 50 mg/ml solution)
500mg reconstitute with 4.8 ml WFI (to make 5.0 ml 100 mg/ml solution)
Further Dilution
IV infusion
Dilute 1 vial to 125 – 250 ml diluent
Continuous IV infusion
Dilute dose ≤ 500 mg with 250 ml diluent and dose > 500 mg with 500 ml diluent
Maximum concentration 2 mg/ml
Diluent
NS, D5
Administration & Infusion rate
IM
Slow IV
Administer the reconstituted solution over at least 3 – 5 min
IV infusion
Administer over 60 min
Continuous IV infusion
Administer over 6 – 12 hr
Storage & Stability
RT
(<25 oC)
Fridge
(2 – 8 oC)
After Reconstitution
Use immediately
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After dilution
24 hr
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Remarks
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