FLUMAZENIL

Brand Name & Strength

Flumazenil-hameln 0.5 mg/5 ml injection

Reconstitution

Not required

Further Dilution

IV infusion

Dilute 10 – 50 ml Flumazenil in 500 ml diluent (concentration: 2 – 10 mcg/ml)

Diluent

NS, D5, lactated Ringer’s solution

Administration & Infusion rate

IV bolus

Administer undiluted over large vein through free-flowing IV solution over 15 – 30 sec. (15 sec for reversal of conscious sedation and general anaesthesia and 30 sec for benzodiazepine overdose)

IV infusion

Rate of infusion: 0.1 – 0.4 mg/hr

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

24 hr

Remarks

If symptoms of overstimulation arise during the use of Flumazenil, then Diazepam or Midazolam may be administered by slow intravenous injection

Rapid injection of high doses (> 1 mg) of Flumazenil should be avoided in patients receiving chronic treatment with benzodiazepines as this may cause withdrawal symptoms