Montelukast

Prophylaxis of asthma

10 mg at night

Molecular weight :608.2 (as sodium salt)

%Protein binding :>99

%Excreted unchanged in urine : <0.2

Volume of distribution (L/kg) :8–11 litres

half-life – normal/ESRD (hrs) :2.7–5.5

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Not dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

None known

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Oral

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Metabolites have minimal therapeutic activity.